{"id":31461,"date":"2023-10-09T16:23:22","date_gmt":"2023-10-09T16:23:22","guid":{"rendered":"https:\/\/amelie-project.eu\/?post_type=publication&#038;p=31461"},"modified":"2024-02-26T16:30:40","modified_gmt":"2024-02-26T16:30:40","slug":"publicacao-4","status":"publish","type":"publication","link":"https:\/\/amelie-project.eu\/pt\/publicacao\/publicacao-4\/","title":{"rendered":"Construir an\u00e9is com esferas: uma abordagem de terapia celular \u00e0 incontin\u00eancia"},"content":{"rendered":"<p>[et_pb_section fb_built=\u201d1\u2033 _builder_version=\u201d4.16\u2033 global_colors_info=\u201d{}\u201d theme_builder_area=\u201dpost_content\u201d][et_pb_row _builder_version=\u201d4.21.0\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d hover_enabled=\u201d0\u2033 global_colors_info=\u201d{}\u201d theme_builder_area=\u201dpost_content\u201d width=\u201d100%\u201d sticky_enabled=\u201d0\u2033][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d theme_builder_area=\u201dpost_content\u201d][et_pb_text _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d global_colors_info=\u201d{}\u201d theme_builder_area=\u201dpost_content\u201d]<!-- divi:paragraph --><\/p>\n<p><strong>Martha Gilbert, Simona \u010caputov\u00e1, Delielena Poli, Manou Kooy, Georgia Sturt, Josephine Parker e Richard M Day.<\/strong><\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p>Cell &amp; Gene Therapy Insights 2023; 9(10), 1293-1306.<\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p>A incontin\u00eancia fecal \u00e9 uma doen\u00e7a prevalente, que continua a ser muito subnotificada. Esta doen\u00e7a afecta a qualidade de vida dos doentes e tem um impacto socioecon\u00f3mico e ambiental negativo na sociedade. As actuais diretrizes de gest\u00e3o de doentes recomendam uma abordagem faseada para o tratamento da incontin\u00eancia fecal, desde op\u00e7\u00f5es de tratamento conservadoras, passando por op\u00e7\u00f5es cir\u00fargicas minimamente invasivas, at\u00e9 op\u00e7\u00f5es cir\u00fargicas de primeira e segunda linha. Infelizmente, os tratamentos conservadores continuam a ser ineficazes e, em muitos casos, as op\u00e7\u00f5es cir\u00fargicas n\u00e3o s\u00e3o desej\u00e1veis ou n\u00e3o s\u00e3o adequadas. A medicina regenerativa e, especificamente, a terapia celular, tem o potencial de oferecer um tratamento curativo que \u00e9 menos invasivo, mais eficaz e eficiente. As tecnologias de terapia celular, embora ainda em desenvolvimento, podem melhorar a situa\u00e7\u00e3o atual no dom\u00ednio da incontin\u00eancia fecal a n\u00edvel cl\u00ednico, do doente e socioecon\u00f3mico. O objetivo deste artigo \u00e9 duplo. Em primeiro lugar, \u00e9 sensibilizar para a doen\u00e7a silenciosa que \u00e9 a incontin\u00eancia fecal e para o impacto que tem nos doentes e na sociedade. Em segundo lugar, pretende-se posicionar a terapia celular em rela\u00e7\u00e3o \u00e0s abordagens de tratamento actuais, incluindo, por exemplo, a estimula\u00e7\u00e3o do nervo sacral e a esfincteroplastia, de modo a enfatizar o seu potencial para proporcionar uma alternativa de tratamento adequada. <\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p>Aceder ao documento completo aqui:<\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p><a href=\"https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence\">https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence<\/a><\/p>\n<p><!-- \/divi:paragraph -->[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>Martha Gilbert, Simona \u010caputov\u00e1, Delielena Poli, Manou Kooy, Georgia Sturt, Josephine Parker e Richard M Day. Cell &amp; Gene Therapy Insights 2023; 9(10), 1293\u20131306. A incontin\u00eancia fecal \u00e9 uma condi\u00e7\u00e3o prevalente, que continua a ser amplamente subnotificada. A condi\u00e7\u00e3o afeta a qualidade de vida dos doentes e tem um impacto socioecon\u00f3mico e ambiental negativo na sociedade. As diretrizes atuais de gest\u00e3o de doentes recomendam uma abordagem gradual para o tratamento da incontin\u00eancia fecal, desde op\u00e7\u00f5es de tratamento conservadoras, passando por op\u00e7\u00f5es cir\u00fargicas minimamente invasivas, at\u00e9 \u00e0s op\u00e7\u00f5es cir\u00fargicas de primeira e segunda linha. Infelizmente, os tratamentos conservadores continuam a ser ineficazes e, em muitos casos, as op\u00e7\u00f5es cir\u00fargicas n\u00e3o s\u00e3o desej\u00e1veis ou adequadas. A medicina regenerativa e, especificamente, a terapia celular, t\u00eam o potencial de oferecer um tratamento curativo menos invasivo, mais eficaz e eficiente. As tecnologias de terapia celular, embora ainda em desenvolvimento, podem melhorar o panorama atual no dom\u00ednio da incontin\u00eancia fecal a n\u00edvel cl\u00ednico, do doente e socioecon\u00f3mico. O objetivo deste artigo \u00e9 duplo. Em primeiro lugar, \u00e9 sensibilizar para a afli\u00e7\u00e3o silenciosa que \u00e9 a incontin\u00eancia fecal e para o impacto que tem nos doentes e na sociedade. Em segundo lugar, \u00e9 posicionar a terapia celular em rela\u00e7\u00e3o \u00e0s abordagens terap\u00eauticas atuais, incluindo, por exemplo, a estimula\u00e7\u00e3o do nervo sacro [\u2026]<\/p>","protected":false},"featured_media":31463,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<!-- wp:paragraph -->\n<p><strong>Martha Gilbert, Simona \u010caputov\u00e1, Delielena Poli, Manou Kooy, Georgia Sturt, Josephine Parker and Richard M Day.<\/strong><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Cell &amp; Gene Therapy Insights 2023; 9(10), 1293\u20131306.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Fecal incontinence is a prevalent condition, that remains vastly underreported. The condition impacts the patients\u2019 quality of life and has negative socio-economic and environmental impact on the society. Current patient management guidelines recommend a stepwise approach to treating fecal incontinence, from conservative treatment options, through minimally invasive surgical options, all the way to first- and second-line surgical options. Unfortunately, the conservative treatments remain ineffective, and, in many cases, the surgical options are either not desirable or not suitable. Regenerative medicine, and specifically, cell therapy, has the potential to offer a curative treatment that is less invasive, more effective and efficient. Cell therapy technologies, while still under development, can improve the current state-of-play in the realm of fecal incontinence at the clinical, patient, and socio-economic level. The aim of this article is twofold. Firstly, it is to raise awareness about the silent affliction that fecal incontinence is and about the impact that it has on patients and society. Secondly, it is to position cell therapy, relative to the current treatment approaches, including, for example, sacral nerve stimulation and sphincteroplasty, as to emphasize its potential to provide a suitable treatment alternative. <\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Access the full paper here:<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><a href=\"https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence\">https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence<\/a><\/p>\n<!-- \/wp:paragraph -->","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_links_to":"","_links_to_target":""},"categories":[43],"class_list":["post-31461","publication","type-publication","status-publish","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/publication\/31461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/types\/publication"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/media\/31463"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/media?parent=31461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/categories?post=31461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}