{"id":31811,"date":"2026-07-01T15:31:55","date_gmt":"2026-07-01T15:31:55","guid":{"rendered":"https:\/\/amelie-project.eu\/?p=31811"},"modified":"2026-07-01T15:35:57","modified_gmt":"2026-07-01T15:35:57","slug":"atualizacao-do-projeto-amelie-alcancados-marcos-importantes-na-fase-inicial-dos-ensaios-clinicos","status":"publish","type":"post","link":"https:\/\/amelie-project.eu\/pt\/atualizacao-do-projeto-amelie-alcancados-marcos-importantes-na-fase-inicial-dos-ensaios-clinicos\/","title":{"rendered":"Atualiza\u00e7\u00e3o do Projeto AMELIE: Alcan\u00e7ados os primeiros marcos do ensaio cl\u00ednico"},"content":{"rendered":"[et_pb_section fb_built=”1″ admin_label=”section” _builder_version=”4.16″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row admin_label=”row” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”|||0px||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][et_pb_text admin_label=”Text” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}” theme_builder_area=”post_content”]
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Temos o prazer de partilhar um marco importante no projeto AMELIE, que est\u00e1 a desenvolver um tratamento regenerativo inovador para a incontin\u00eancia fecal.

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At\u00e9 \u00e0 data, quatro doentes foram tratados no The Royal London Hospital, em Londres, e dois doentes foram tratados no Hospital Universit\u00e1rio do Pa\u00eds de Gales, em Cardiff, no \u00e2mbito do ensaio cl\u00ednico em curso.<\/p>\n<\/div>\n

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Isto representa um avan\u00e7o significativo na avalia\u00e7\u00e3o de uma nova terapia celular que visa restaurar a fun\u00e7\u00e3o do esf\u00edncter atrav\u00e9s da utiliza\u00e7\u00e3o de c\u00e9lulas aut\u00f3logas derivadas do m\u00fasculo esquel\u00e9tico, fixadas a microportadores implant\u00e1veis. Esta abordagem foi concebida para melhorar a sobreviv\u00eancia celular, apoiar a repara\u00e7\u00e3o dos tecidos e, em \u00faltima an\u00e1lise, melhorar os resultados em termos de contin\u00eancia para os doentes que vivem com esta condi\u00e7\u00e3o complexa.<\/p>\n<\/div>\n


Cada percurso cl\u00ednico do doente come\u00e7a com uma bi\u00f3psia muscular para recolher as c\u00e9lulas necess\u00e1rias \u00e0 produ\u00e7\u00e3o da terapia personalizada. Estas c\u00e9lulas s\u00e3o, em seguida, processadas e preparadas para implanta\u00e7\u00e3o, antes de serem administradas ao doente num dos centros cl\u00ednicos participantes.<\/div>\n

O tratamento destes seis doentes representa um marco fundamental na transi\u00e7\u00e3o do AMELIE do desenvolvimento laboratorial para a pr\u00e1tica cl\u00ednica. Reflete tamb\u00e9m a estreita colabora\u00e7\u00e3o entre cirurgi\u00f5es, cientistas, equipas de fabrico e pessoal envolvido nos ensaios cl\u00ednicos em todo o Reino Unido.<\/div>\n

\u00c0 medida que o ensaio cl\u00ednico for avan\u00e7ando, a equipa continuar\u00e1 a acompanhar atentamente os resultados, a fim de avaliar a seguran\u00e7a e os primeiros ind\u00edcios de efic\u00e1cia.<\/div>\n

Estamos ansiosos por partilhar mais novidades \u00e0 medida que este estudo pioneiro for avan\u00e7ando.<\/div>\n
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<\/em><\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]","protected":false},"excerpt":{"rendered":"

We are pleased to share an important milestone in the AMELIE project, which is developing a novel regenerative treatment for faecal incontinence. To date, four patients have been treated at The Royal London Hospital in London, and two patients have been treated at the University Hospital of Wales in Cardiff as part of the ongoing clinical trial. This marks a significant step forward in the evaluation of a new cell-based therapy that aims to restore sphincter function by using autologous skeletal muscle-derived cells attached to implantable microcarriers. The approach is designed to improve cell survival, support tissue repair, and ultimately improve continence outcomes for patients living with this challenging condition. Each patient pathway begins with a muscle biopsy to collect the cells needed to manufacture the personalised therapy. These cells are then processed and prepared for implantation, before being delivered back to the patient at one of the participating clinical sites. The treatment of these six patients represents a key milestone in the translation of AMELIE from laboratory development into clinical practice. It also reflects the close collaboration between surgeons, scientists, manufacturing teams, and clinical trial staff across the UK. As the trial progresses, the team will continue carefully monitor […]<\/p>","protected":false},"author":6,"featured_media":31815,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" admin_label=\"section\" _builder_version=\"4.16\" global_colors_info=\"{}\" theme_builder_area=\"post_content\"][et_pb_row admin_label=\"row\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_padding=\"|||0px||\" global_colors_info=\"{}\" theme_builder_area=\"post_content\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" custom_padding__hover=\"|||\" theme_builder_area=\"post_content\"][et_pb_text admin_label=\"Text\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" global_colors_info=\"{}\" theme_builder_area=\"post_content\"]

The first patient was recently treated in the AMELIE clinical trial during April 2026. The team at The Royal London Hospital implanted healthy muscle cells attached to microscopic beads in humans for the first time. The study aims to treat faecal incontinence caused by childbirth injury.<\/span><\/p>\n

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The first patients had been biopsied two weeks prior to this in Cardiff at the University Hospital of Wales.<\/p>\n

These are important milestones for the progression of this groundbreaking treatment. The team looks forward to treating the remaining patients enrolled in the trial in the coming months.<\/p>\n<\/div>\n

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