{"id":28691,"date":"2020-09-05T00:19:04","date_gmt":"2020-09-05T00:19:04","guid":{"rendered":"https:\/\/amelie-project.eu\/?page_id=28691"},"modified":"2021-01-25T12:42:37","modified_gmt":"2021-01-25T12:42:37","slug":"visao-e-objectivos","status":"publish","type":"page","link":"https:\/\/amelie-project.eu\/pt\/visao-e-objectivos\/","title":{"rendered":"Vis\u00e3o e objectivos"},"content":{"rendered":"[et_pb_section fb_built=”1″ admin_label=”Hero section” _builder_version=”4.6.3″ _module_preset=”ac17d3a6-8373-45ed-95ce-70484e82a9b6″ use_background_color_gradient=”off” saved_tabs=”all”][et_pb_row use_custom_gutter=”on” gutter_width=”1″ custom_padding_last_edited=”on|desktop” _builder_version=”4.6.3″ _module_preset=”default” width=”100%” module_alignment=”left” custom_padding=”|||4%|false|false” custom_padding_tablet=”|||6%|false|false” custom_padding_phone=”|||7%|false|false”][et_pb_column type=”4_4″ _builder_version=”4.6.3″ _module_preset=”default”][dsm_block_reveal_text block_reveal_text=”VISION” heading_html_tag=”h1″ block_reveal_color=”#0e94f9″ block_reveal_delay=”0″ _builder_version=”4.6.3″ _module_preset=”default” header_font=”AMELIE||||||||” header_text_color=”#0e94f9″ header_font_size=”4vw” custom_padding=”||||false|false” custom_padding_tablet=”||||false|false” custom_padding_phone=”||||false|false” custom_padding_last_edited=”on|phone” header_font_size_tablet=”8vw” header_font_size_phone=”10vw” header_font_size_last_edited=”on|desktop”][\/dsm_block_reveal_text][dsm_block_reveal_text block_reveal_text=”AND OBJECTIVES” block_reveal_color=”#0e94f9″ _builder_version=”4.6.3″ _module_preset=”default” header_font=”AMELIE||||||||” header_text_color=”#0e94f9″ header_font_size=”3vw” custom_padding=”||||false|false” custom_padding_tablet=”||||false|false” custom_padding_phone=”||||false|false” custom_padding_last_edited=”on|phone” header_font_size_tablet=”5vw” header_font_size_phone=”6vw” header_font_size_last_edited=”on|phone”][\/dsm_block_reveal_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Features” _builder_version=”4.6.3″ background_enable_color=”off” custom_padding=”100px|0px|100px|0px||”][et_pb_row column_structure=”1_3,1_3,1_3″ admin_label=”Sending Payments” _builder_version=”3.25″ max_width=”1440px” custom_margin=”|||” use_custom_width=”on” custom_width_px=”1440px”][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/shutterstock_1069097789-Converted-1.png” title_text=”shutterstock_1069097789 %91Converted%93″ align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.6.3″ animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”10%”][\/et_pb_image][et_pb_text _builder_version=”4.6.3″ text_font=”Gotham kinda bold||||||||” text_font_size=”16px” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”Gotham kinda bold||||||||” header_2_text_color=”#000000″ header_2_font_size=”32px” header_2_line_height=”1.3em” header_3_font=”||||||||” header_4_font=”||||||||” text_orientation=”center” hover_enabled=”0″ sticky_enabled=”0″ text_text_color=”#000000″]

A nossa miss\u00e3o<\/h2>\n

O cons\u00f3rcio prop\u00f5e uma abordagem translacional radical e inovadora para fabricar e fornecer c\u00e9lulas dependentes de ancoragem no corpo, como uma forma de nova terapia celular, para estabelecer terapias de medicina regenerativa mais eficazes para a FI e outras indica\u00e7\u00f5es cl\u00ednicas.<\/p>[\/et_pb_text][et_pb_button button_url=”\/approach\/” button_text=”LEARN MORE” button_alignment=”center” _builder_version=”4.6.3″ _module_preset=”default” custom_button=”on” button_text_size=”12px” button_text_color=”#000000″ button_bg_color=”#ffffff” button_border_width=”1px” button_border_color=”#000000″ button_border_radius=”5px” button_letter_spacing=”2px” button_font=”Gotham kinda bold|600||on|||||” button_icon=”%%20%%” button_icon_color=”#000000″ button_on_hover=”off” custom_margin=”-17px||||false|false” custom_padding=”12px|30px|12px|20px|false|false” animation_style=”fold” animation_duration=”850ms” animation_intensity_fold=”16%” hover_enabled=”0″ button_letter_spacing_tablet=”” button_letter_spacing_phone=”1px” button_letter_spacing_last_edited=”on|phone” button_bg_color__hover=”#0c71c3″ button_bg_color__hover_enabled=”on|desktop” button_border_color__hover=”rgba(0,0,0,0)” button_border_color__hover_enabled=”on|desktop” button_letter_spacing__hover=”2px” button_letter_spacing__hover_enabled=”off|desktop” box_shadow_vertical_button__hover=”8px” box_shadow_vertical_button__hover_enabled=”on|hover” box_shadow_color__hover_enabled=”on|hover” box_shadow_color__hover=”rgba(7,82,140,0.54)” box_shadow_vertical__hover_enabled=”on|desktop” box_shadow_vertical__hover=”10px” button_bg_enable_color__hover=”on” button_text_color__hover_enabled=”on|desktop” button_text_color__hover=”#ffffff” button_border_width__hover_enabled=”on|hover” button_border_width__hover=”1px” button_icon_color__hover_enabled=”on|desktop” button_icon_color__hover=”#ffffff” sticky_enabled=”0″][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/shutterstock_1289992183-Converted-1.png” title_text=”shutterstock_1289992183 %91Converted%93″ align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.6.3″ width=”210px” custom_margin=”60px|||” animation_style=”slide” animation_direction=”bottom” animation_delay=”200ms” animation_intensity_slide=”10%” locked=”off”][\/et_pb_image][et_pb_text _builder_version=”4.6.3″ text_font=”Gotham kinda bold||||||||” text_font_size=”16px” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”Gotham kinda bold||||||||” header_2_text_color=”#000000″ header_2_font_size=”32px” header_2_line_height=”1.3em” header_3_font=”||||||||” header_4_font=”||||||||” text_orientation=”center” locked=”off” text_text_color=”#000000″ hover_enabled=”0″ sticky_enabled=”0″]

A condi\u00e7\u00e3o<\/h2>\n

A incontin\u00eancia fecal \u00e9 uma condi\u00e7\u00e3o comum. Embora n\u00e3o ponha em risco a vida, \u00e9 classificada como uma doen\u00e7a pela Organiza\u00e7\u00e3o Mundial de Sa\u00fade (OMS), prejudicando seriamente a vida quotidiana e a produtividade dos indiv\u00edduos afectados e das suas fam\u00edlias, e resultando num encargo substancial para os servi\u00e7os de sa\u00fade europeus. Existe uma necessidade terap\u00eautica particular n\u00e3o satisfeita para os doentes com sintomas graves de incontin\u00eancia fecal (IF), que n\u00e3o s\u00e3o adequados ou n\u00e3o desejam submeter-se \u00e0s op\u00e7\u00f5es cir\u00fargicas atualmente dispon\u00edveis, mas que podem beneficiar de uma abordagem m\u00e9dica regenerativa.<\/p>[\/et_pb_text][et_pb_button button_url=”\/our-research\/” button_text=”LEARN MORE” button_alignment=”center” _builder_version=”4.6.3″ _module_preset=”default” custom_button=”on” button_text_size=”12px” button_text_color=”#000000″ button_bg_color=”#ffffff” button_border_width=”1px” button_border_color=”#000000″ button_border_radius=”5px” button_letter_spacing=”2px” button_font=”Gotham kinda bold|600||on|||||” button_icon=”%%20%%” button_icon_color=”#000000″ button_on_hover=”off” custom_margin=”-17px||||false|false” custom_padding=”12px|30px|12px|20px|false|false” animation_style=”fold” animation_duration=”850ms” animation_intensity_fold=”16%” button_letter_spacing_tablet=”” button_letter_spacing_phone=”1px” button_letter_spacing_last_edited=”on|phone” button_bg_color__hover=”#0c71c3″ button_bg_color__hover_enabled=”on|desktop” button_border_color__hover=”rgba(0,0,0,0)” button_border_color__hover_enabled=”on|desktop” button_letter_spacing__hover=”2px” button_letter_spacing__hover_enabled=”on|desktop” box_shadow_vertical_button__hover=”8px” box_shadow_vertical_button__hover_enabled=”on|hover” box_shadow_color__hover_enabled=”on|hover” box_shadow_color__hover=”rgba(7,82,140,0.54)” box_shadow_vertical__hover_enabled=”on|desktop” box_shadow_vertical__hover=”10px” button_text_color__hover=”#ffffff” button_text_color__hover_enabled=”on|desktop” button_border_width__hover=”1px” button_border_width__hover_enabled=”on|hover” button_icon_color__hover=”#ffffff” button_icon_color__hover_enabled=”on|desktop”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/12\/shutterstock_1069097789-Converted.png” title_text=”shutterstock_1069097789 %91Converted%93″ align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.6.3″ custom_padding=”||||false|false” custom_padding_tablet=”50px||||false|false” custom_padding_phone=”” custom_padding_last_edited=”on|desktop” animation_style=”slide” animation_direction=”bottom” animation_duration=”100ms” animation_intensity_slide=”10%”][\/et_pb_image][et_pb_text _builder_version=”4.6.3″ text_font=”Gotham kinda bold||||||||” text_font_size=”16px” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”Gotham kinda bold||||||||” header_2_text_color=”#000000″ header_2_font_size=”32px” header_2_line_height=”1.3em” header_3_font=”||||||||” header_4_font=”||||||||” text_orientation=”center” locked=”off” text_text_color=”#000000″]

A nossa vis\u00e3o<\/h2>\n

A AMELIE desenvolver\u00e1 um novo produto de engenharia de tecidos (medicamento de terapia avan\u00e7ada combinada) que inclui a liga\u00e7\u00e3o das c\u00e9lulas dependentes de ancoragem a um microportador implant\u00e1vel biodegrad\u00e1vel e clinicamente qualificado, de modo a melhorar diretamente os sintomas cl\u00ednicos da IF.<\/p>[\/et_pb_text][et_pb_button button_url=”\/engagement-activities\/” button_text=”LEARN MORE” button_alignment=”center” _builder_version=”4.6.3″ _module_preset=”default” custom_button=”on” button_text_size=”12px” button_text_color=”#000000″ button_bg_color=”#ffffff” button_border_width=”1px” button_border_color=”#000000″ button_border_radius=”5px” button_letter_spacing=”2px” button_font=”Gotham kinda bold|600||on|||||” button_icon=”%%20%%” button_icon_color=”#000000″ button_on_hover=”off” custom_margin=”-17px||||false|false” custom_padding=”12px|30px|12px|20px|false|false” animation_style=”fold” animation_duration=”850ms” animation_intensity_fold=”16%” button_letter_spacing_tablet=”” button_letter_spacing_phone=”1px” button_letter_spacing_last_edited=”on|phone” button_bg_color__hover=”#0c71c3″ button_bg_color__hover_enabled=”on|desktop” button_border_color__hover=”rgba(0,0,0,0)” button_border_color__hover_enabled=”on|desktop” button_letter_spacing__hover=”2px” button_letter_spacing__hover_enabled=”on|desktop” box_shadow_vertical_button__hover=”8px” box_shadow_vertical_button__hover_enabled=”on|hover” box_shadow_color__hover_enabled=”on|hover” box_shadow_color__hover=”rgba(7,82,140,0.54)” box_shadow_vertical__hover_enabled=”on|desktop” box_shadow_vertical__hover=”10px” button_text_color__hover=”#ffffff” button_text_color__hover_enabled=”on|desktop” button_border_width__hover=”1px” button_border_width__hover_enabled=”on|hover” button_icon_color__hover=”#ffffff” button_icon_color__hover_enabled=”on|desktop”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Stats and Features” _builder_version=”3.22″ background_color=”#f7f8fc” custom_padding=”80px|0px|54px|0px|false|false”][et_pb_row use_custom_gutter=”on” gutter_width=”4″ _builder_version=”4.6.3″ custom_margin=”||||false|false” custom_padding=”0px|||”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” parallax__hover=”off” parallax_method__hover=”on” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.3″ _module_preset=”default” header_font=”Gotham||||||||” header_2_font=”Gotham kinda bold||||||||” header_2_text_align=”center” header_2_text_color=”#000000″ header_2_font_size=”5vh” header_2_line_height=”1.2em” hover_enabled=”0″ sticky_enabled=”0″]

AMELIE Objectivos<\/h2>[\/et_pb_text][et_pb_blurb title=”Objective 1:” url=”#” icon_placement=”left” image_max_width=”64px” content_max_width=”1093px” admin_label=”Chapter” _builder_version=”4.6.3″ header_font=”Gotham kinda bold||||||||” header_text_align=”center” header_text_color=”#000000″ header_line_height=”1.5em” body_font=”Gotham kinda bold||||||||” body_text_color=”#000000″ body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” max_width=”1500px” module_alignment=”center” custom_margin=”||30px||false|false” custom_padding=”30px|40px|30px|40px” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” hover_enabled=”0″ box_shadow_style=”preset2″ box_shadow_horizontal=”0px” box_shadow_vertical=”0px” box_shadow_blur=”60px” box_shadow_color=”rgba(20,8,7,0.08)” locked=”off” sticky_enabled=”0″]

Estabelecer novos processos robustos para o fabrico, carateriza\u00e7\u00e3o, transporte e entrega de microtransportadores biodegrad\u00e1veis e implant\u00e1veis<\/span><\/p>[\/et_pb_blurb][et_pb_blurb title=”Objective 2:” url=”#” icon_placement=”left” image_max_width=”64px” content_max_width=”1400px” admin_label=”Chapter” _builder_version=”4.6.3″ header_font=”Gotham kinda bold||||||||” header_text_align=”center” header_text_color=”#000000″ header_line_height=”1.5em” body_font=”Gotham kinda bold||||||||” body_text_color=”#000000″ body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” max_width=”1500px” module_alignment=”center” custom_margin=”||30px||false|false” custom_padding=”30px|40px|30px|40px” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” hover_enabled=”0″ box_shadow_style=”preset2″ box_shadow_horizontal=”0px” box_shadow_vertical=”0px” box_shadow_blur=”60px” box_shadow_color=”rgba(20,8,7,0.08)” locked=”off” sticky_enabled=”0″]

Demonstrar a seguran\u00e7a dos microtransportadores ASMDC utilizando testes n\u00e3o cl\u00ednicos para cumprir os requisitos regulamentares nacionais e criar um resumo do produto que permita a avalia\u00e7\u00e3o da tecnologia em toda a Europa.<\/span><\/p>[\/et_pb_blurb][et_pb_blurb title=”Objective 3:” url=”#” icon_placement=”left” image_max_width=”64px” content_max_width=”1127px” admin_label=”Chapter” _builder_version=”4.6.3″ header_font=”Gotham kinda bold||||||||” header_text_align=”center” header_text_color=”#000000″ header_line_height=”1.5em” body_font=”Gotham kinda bold||||||||” body_text_color=”#000000″ body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” max_width=”1500px” module_alignment=”center” custom_margin=”||30px||false|false” custom_padding=”30px|40px|30px|40px” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” hover_enabled=”0″ box_shadow_style=”preset2″ box_shadow_horizontal=”0px” box_shadow_vertical=”0px” box_shadow_blur=”60px” box_shadow_color=”rgba(20,8,7,0.08)” locked=”off” sticky_enabled=”0″]

Realizar um ensaio pan-europeu aleat\u00f3rio e em dupla oculta\u00e7\u00e3o para determinar se os microtransportadores conduzem a uma redu\u00e7\u00e3o da frequ\u00eancia dos epis\u00f3dios de FI.<\/span><\/p>[\/et_pb_blurb][et_pb_blurb title=”Objective 4:” url=”#” icon_placement=”left” image_max_width=”64px” content_max_width=”1400px” admin_label=”Chapter” _builder_version=”4.6.3″ header_font=”Gotham kinda bold||||||||” header_text_align=”center” header_text_color=”#000000″ header_line_height=”1.5em” body_font=”Gotham kinda bold||||||||” body_text_color=”#000000″ body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” max_width=”1500px” module_alignment=”center” custom_margin=”||30px||false|false” custom_padding=”30px|40px|30px|40px” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” hover_enabled=”0″ box_shadow_style=”preset2″ box_shadow_horizontal=”0px” box_shadow_vertical=”0px” box_shadow_blur=”60px” box_shadow_color=”rgba(20,8,7,0.08)” locked=”off” sticky_enabled=”0″]

Envolver as sociedades nacionais e regionais com o apoio das institui\u00e7\u00f5es de caridade europeias, das redes de apoio aos doentes e do p\u00fablico para estabelecer canais para a atividade da IPP e a divulga\u00e7\u00e3o dos desenvolvimentos do projeto aos doentes, ao p\u00fablico e \u00e0 comunidade cient\u00edfica.<\/p>[\/et_pb_blurb][et_pb_blurb title=”Objective 5:” url=”#” icon_placement=”left” image_max_width=”64px” content_max_width=”1051px” admin_label=”Chapter” _builder_version=”4.6.3″ header_font=”Gotham kinda bold||||||||” header_text_align=”center” header_text_color=”#000000″ header_line_height=”1.5em” body_font=”Gotham kinda bold||||||||” body_text_color=”#000000″ body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” max_width=”1500px” module_alignment=”center” custom_margin=”||30px||false|false” custom_padding=”30px|40px|25px|40px|false|false” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” hover_enabled=”0″ box_shadow_style=”preset2″ box_shadow_horizontal=”0px” box_shadow_vertical=”0px” box_shadow_blur=”60px” box_shadow_color=”rgba(20,8,7,0.08)” locked=”off” sticky_enabled=”0″]

Desenvolver um plano de neg\u00f3cios e uma futura estrat\u00e9gia de comercializa\u00e7\u00e3o para permitir o acesso dos doentes ao microcarrier em toda a Europa e no mundo.<\/span><\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.6.3″ _module_preset=”default”][\/et_pb_section]","protected":false},"excerpt":{"rendered":"

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VIS\u00c3O<\/h1><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>
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E OBJECTIVOS<\/h2><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Our Mission The consortium proposes a radical, innovative translational approach to manufacture and deliver anchorage-dependent cells into the body, as a form of new cell therapy, to establish more effective regenerative medicine therapies for FI and other clinical indications.The Condition Faecal incontinence is a common condition. Whilst not life threatening, it is classified as a disease by the World Health Organization (WHO), seriously impairing daily living and productivity of affected individuals and their families, and resulting in a substantial burden on European health services. There is a particular therapeutic unmet need for patients with severe symptoms of faecal incontinence (FI), who are either unsuitable for, or do not wish to undergo, currently available surgical options, but who may benefit from a regenerative medical approach.Our Vision AMELIE will develop a novel tissue engineered product (combined advanced therapy medicinal product) that comprises attaching the anchorage dependent cells to an implantable biodegradable, clinically qualified microcarrier so as to directly improve the clinical symptoms of FI.AMELIE ObjectivesEstablish new robust processes for the manufacturing, […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-28691","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/pages\/28691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/comments?post=28691"}],"version-history":[{"count":38,"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/pages\/28691\/revisions"}],"predecessor-version":[{"id":31170,"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/pages\/28691\/revisions\/31170"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/pt\/wp-json\/wp\/v2\/media?parent=28691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}