{"id":31461,"date":"2023-10-09T16:23:22","date_gmt":"2023-10-09T16:23:22","guid":{"rendered":"https:\/\/amelie-project.eu\/?post_type=publication&#038;p=31461"},"modified":"2024-02-26T16:30:40","modified_gmt":"2024-02-26T16:30:40","slug":"pubblicazione-4","status":"publish","type":"publication","link":"https:\/\/amelie-project.eu\/it\/pubblicazione\/pubblicazione-4\/","title":{"rendered":"Costruire anelli con sfere: un approccio di terapia cellulare all'incontinenza"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_row _builder_version=&#8221;4.21.0&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221; width=&#8221;100%&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<!-- divi:paragraph --><\/p>\n<p><strong>Martha Gilbert, Simona \u010caputov\u00e1, Delielena Poli, Manou Kooy, Georgia Sturt, Josephine Parker e Richard M Day.<\/strong><\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p>Cell &amp; Gene Therapy Insights 2023; 9(10), 1293-1306.<\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p>L'incontinenza fecale \u00e8 una condizione prevalente, che rimane ampiamente sottovalutata. Questa condizione influisce sulla qualit\u00e0 di vita dei pazienti e ha un impatto socio-economico e ambientale negativo sulla societ\u00e0. Le attuali linee guida per la gestione dei pazienti raccomandano un approccio graduale al trattamento dell'incontinenza fecale, dalle opzioni di trattamento conservativo, alle opzioni chirurgiche minimamente invasive, fino alle opzioni chirurgiche di prima e seconda linea. Purtroppo, i trattamenti conservativi rimangono inefficaci e, in molti casi, le opzioni chirurgiche non sono desiderabili o non sono adatte. La medicina rigenerativa, e in particolare la terapia cellulare, ha il potenziale per offrire un trattamento curativo meno invasivo, pi\u00f9 efficace ed efficiente. Le tecnologie di terapia cellulare, pur essendo ancora in fase di sviluppo, possono migliorare l'attuale situazione nel campo dell'incontinenza fecale a livello clinico, del paziente e socio-economico. Lo scopo di questo articolo \u00e8 duplice. In primo luogo, sensibilizzare l'opinione pubblica sulla malattia silenziosa dell'incontinenza fecale e sull'impatto che essa ha sui pazienti e sulla societ\u00e0. In secondo luogo, si tratta di posizionare la terapia cellulare rispetto agli attuali approcci terapeutici, tra cui, ad esempio, la stimolazione del nervo sacrale e la sfinteroplastica, per sottolineare il suo potenziale nel fornire un'alternativa terapeutica adeguata. <\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p>Accedere al documento completo qui:<\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p><a href=\"https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence\">https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence<\/a><\/p>\n<p><!-- \/divi:paragraph -->[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>Martha Gilbert, Simona \u010caputov\u00e1, Delielena Poli, Manou Kooy, Georgia Sturt, Josephine Parker and Richard M Day. Cell &amp; Gene Therapy Insights 2023; 9(10), 1293\u20131306. Fecal incontinence is a prevalent condition, that remains vastly underreported. The condition impacts the patients\u2019 quality of life and has negative socio-economic and environmental impact on the society. Current patient management guidelines recommend a stepwise approach to treating fecal incontinence, from conservative treatment options, through minimally invasive surgical options, all the way to first- and second-line surgical options. Unfortunately, the conservative treatments remain ineffective, and, in many cases, the surgical options are either not desirable or not suitable. Regenerative medicine, and specifically, cell therapy, has the potential to offer a curative treatment that is less invasive, more effective and efficient. Cell therapy technologies, while still under development, can improve the current state-of-play in the realm of fecal incontinence at the clinical, patient, and socio-economic level. The aim of this article is twofold. Firstly, it is to raise awareness about the silent affliction that fecal incontinence is and about the impact that it has on patients and society. Secondly, it is to position cell therapy, relative to the current treatment approaches, including, for example, sacral nerve stimulation [&hellip;]<\/p>","protected":false},"featured_media":31463,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<!-- wp:paragraph -->\n<p><strong>Martha Gilbert, Simona \u010caputov\u00e1, Delielena Poli, Manou Kooy, Georgia Sturt, Josephine Parker and Richard M Day.<\/strong><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Cell &amp; Gene Therapy Insights 2023; 9(10), 1293\u20131306.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Fecal incontinence is a prevalent condition, that remains vastly underreported. The condition impacts the patients\u2019 quality of life and has negative socio-economic and environmental impact on the society. Current patient management guidelines recommend a stepwise approach to treating fecal incontinence, from conservative treatment options, through minimally invasive surgical options, all the way to first- and second-line surgical options. Unfortunately, the conservative treatments remain ineffective, and, in many cases, the surgical options are either not desirable or not suitable. Regenerative medicine, and specifically, cell therapy, has the potential to offer a curative treatment that is less invasive, more effective and efficient. Cell therapy technologies, while still under development, can improve the current state-of-play in the realm of fecal incontinence at the clinical, patient, and socio-economic level. The aim of this article is twofold. Firstly, it is to raise awareness about the silent affliction that fecal incontinence is and about the impact that it has on patients and society. Secondly, it is to position cell therapy, relative to the current treatment approaches, including, for example, sacral nerve stimulation and sphincteroplasty, as to emphasize its potential to provide a suitable treatment alternative. <\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Access the full paper here:<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><a href=\"https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence\">https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence<\/a><\/p>\n<!-- \/wp:paragraph -->","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_links_to":"","_links_to_target":""},"categories":[43],"class_list":["post-31461","publication","type-publication","status-publish","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/publication\/31461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/types\/publication"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/media\/31463"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/media?parent=31461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/categories?post=31461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}