{"id":29994,"date":"2023-09-10T09:09:36","date_gmt":"2023-09-10T09:09:36","guid":{"rendered":"https:\/\/amelie-project.eu\/?post_type=category-publication&p=29994"},"modified":"2024-02-26T16:22:58","modified_gmt":"2024-02-26T16:22:58","slug":"pubblicazione-3","status":"publish","type":"publication","link":"https:\/\/amelie-project.eu\/it\/pubblicazione\/pubblicazione-3\/","title":{"rendered":"Considerazioni sul bioprocesso per la produzione di cellule muscolari scheletriche e lisce a scopo terapeutico"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.21.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.21.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral e Cl\u00e1udia L da Silva.<\/strong><\/p>\n

Bioingegneria. 2023;10(9):1067.<\/p>\n

Gli approcci di ingegneria tissutale nel contesto muscolare rappresentano un campo emergente promettente per affrontare le attuali sfide terapeutiche legate a molteplici condizioni patologiche che interessano i comparti muscolari, sia il muscolo scheletrico che il muscolo liscio, responsabili rispettivamente della contrazione involontaria e volontaria. In questa rassegna, vengono affrontate diverse caratteristiche e parametri coinvolti nel bioprocesso delle cellule muscolari. Viene illustrato il processo di isolamento delle cellule, a seconda del tipo di tessuto (muscolo liscio o scheletrico), seguito dalla descrizione delle sfide che comporta l'uso di tessuti di donatori adulti e delle strategie per superare gli ostacoli che impediscono di raggiungere un numero di cellule rilevante per un'applicazione clinica. In particolare, viene evidenziato l'uso di cellule staminali\/progenitrici come fonte di cellule muscolari lisce e scheletriche per lo sviluppo di un prodotto cellulare in grado di mantenere l'identit\u00e0 e la funzionalit\u00e0 della cellula bersaglio. Inoltre, tenendo conto della necessit\u00e0 di un bioprocesso robusto ed economico per la produzione di cellule, vengono affrontate anche la combinazione di cellule muscolari con biomateriali e la necessit\u00e0 di uno scale-up che preveda applicazioni cliniche.<\/p>\n

<\/p>\n

Accedere al documento completo qui:<\/p>\n

<\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/a><\/p>\n

<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral and Cl\u00e1udia L da Silva. Bioengineering. 2023;10(9):1067. Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle or smooth muscle, responsible for involuntary and voluntary contraction, respectively. In this review, several features and parameters involved in the bioprocessing of muscle cells are addressed. The cell isolation process is depicted, depending on the type of tissue (smooth or skeletal muscle), followed by the description of the challenges involving the use of adult donor tissue and the strategies to overcome the hurdles of reaching relevant cell numbers towards a clinical application. Specifically, the use of stem\/progenitor cells is highlighted as a source for smooth and skeletal muscle cells towards the development of a cellular product able to maintain the target cell\u2019s identity and functionality. Moreover, taking into account the need for a robust and cost-effective bioprocess for cell manufacturing, the combination of muscle cells with biomaterials and the need for scale-up envisioning clinical applications are also approached. Access the full paper here: https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/p>","protected":false},"featured_media":31459,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\n

Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral and Cl\u00e1udia L da Silva.
Bioengineering. 2023;10(9):1067.<\/strong><\/p>\n\n\n\n

Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle or smooth muscle, responsible for involuntary and voluntary contraction, respectively. In this review, several features and parameters involved in the bioprocessing of muscle cells are addressed. The cell isolation process is depicted, depending on the type of tissue (smooth or skeletal muscle), followed by the description of the challenges involving the use of adult donor tissue and the strategies to overcome the hurdles of reaching relevant cell numbers towards a clinical application. Specifically, the use of stem\/progenitor cells is highlighted as a source for smooth and skeletal muscle cells towards the development of a cellular product able to maintain the target cell\u2019s identity and functionality. Moreover, taking into account the need for a robust and cost-effective bioprocess for cell manufacturing, the combination of muscle cells with biomaterials and the need for scale-up envisioning clinical applications are also approached.<\/p>\n\n\n\n

Access the full paper here:\u00a0<\/p>\n\n\n\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/a><\/p>\n","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_links_to":"","_links_to_target":""},"categories":[43],"class_list":["post-29994","publication","type-publication","status-publish","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/publication\/29994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/types\/publication"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/media\/31459"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/media?parent=29994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/categories?post=29994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}