{"id":31811,"date":"2026-07-01T15:31:55","date_gmt":"2026-07-01T15:31:55","guid":{"rendered":"https:\/\/amelie-project.eu\/?p=31811"},"modified":"2026-07-01T15:35:57","modified_gmt":"2026-07-01T15:35:57","slug":"aggiornamento-sul-progetto-amelie-raggiunti-i-primi-traguardi-della-sperimentazione-clinica","status":"publish","type":"post","link":"https:\/\/amelie-project.eu\/it\/aggiornamento-sul-progetto-amelie-raggiunti-i-primi-traguardi-della-sperimentazione-clinica\/","title":{"rendered":"Aggiornamento sul progetto AMELIE: raggiunti i primi traguardi della sperimentazione clinica"},"content":{"rendered":"[et_pb_section fb_built=\u201d1\u201d admin_label=\u201dsection\u201d _builder_version=\u201d4.16\u201d global_colors_info=\u201d{}\u201d theme_builder_area=\u201dpost_content\u201d][et_pb_row admin_label=\u201drow\u201d _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d custom_padding=\u201d|||0px||\u201d global_colors_info=\u201d{}\u201d theme_builder_area=\u201dpost_content\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d theme_builder_area=\u201dpost_content\u201d][et_pb_text admin_label=\u201dTesto\u201d _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d global_colors_info=\u201d{}\u201d theme_builder_area=\u201dpost_content\u201d]
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Siamo lieti di annunciare un importante traguardo raggiunto nel progetto AMELIE, volto allo sviluppo di un nuovo trattamento rigenerativo per l\u2019incontinenza fecale.

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Ad oggi, quattro pazienti sono stati sottoposti a trattamento presso il Royal London Hospital di Londra e due pazienti presso l\u2019Ospedale Universitario del Galles a Cardiff, nell\u2019ambito della sperimentazione clinica attualmente in corso.<\/p>\n<\/div>\n

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Questo rappresenta un significativo passo avanti nella valutazione di una nuova terapia cellulare che mira a ripristinare la funzione dello sfintere utilizzando cellule autologhe derivate dal muscolo scheletrico fissate a microvettori impiantabili. L'approccio \u00e8 stato concepito per migliorare la sopravvivenza cellulare, favorire la riparazione dei tessuti e, in ultima analisi, migliorare i risultati in termini di continenza per i pazienti affetti da questa complessa patologia.<\/p>\n<\/div>\n


Il percorso di cura di ciascun paziente inizia con una biopsia muscolare volta a prelevare le cellule necessarie per la produzione della terapia personalizzata. Queste cellule vengono poi trattate e preparate per l\u2019impianto, prima di essere reiniettate nel paziente presso una delle strutture cliniche partecipanti.<\/div>\n

Il trattamento di questi sei pazienti rappresenta una tappa fondamentale nel passaggio di AMELIE dalla fase di sviluppo in laboratorio alla pratica clinica. Esso riflette inoltre la stretta collaborazione tra chirurghi, scienziati, team di produzione e personale addetto alle sperimentazioni cliniche in tutto il Regno Unito.<\/div>\n

Man mano che la sperimentazione procede, il team continuer\u00e0 a monitorare attentamente i risultati per valutare la sicurezza e i primi segnali di efficacia.<\/div>\n

Non vediamo l'ora di condividere ulteriori aggiornamenti man mano che questo studio pionieristico procede.<\/div>\n
<\/div>\n

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We are pleased to share an important milestone in the AMELIE project, which is developing a novel regenerative treatment for faecal incontinence. To date, four patients have been treated at The Royal London Hospital in London, and two patients have been treated at the University Hospital of Wales in Cardiff as part of the ongoing clinical trial. This marks a significant step forward in the evaluation of a new cell-based therapy that aims to restore sphincter function by using autologous skeletal muscle-derived cells attached to implantable microcarriers. The approach is designed to improve cell survival, support tissue repair, and ultimately improve continence outcomes for patients living with this challenging condition. Each patient pathway begins with a muscle biopsy to collect the cells needed to manufacture the personalised therapy. These cells are then processed and prepared for implantation, before being delivered back to the patient at one of the participating clinical sites. The treatment of these six patients represents a key milestone in the translation of AMELIE from laboratory development into clinical practice. It also reflects the close collaboration between surgeons, scientists, manufacturing teams, and clinical trial staff across the UK. As the trial progresses, the team will continue carefully monitor […]<\/p>","protected":false},"author":6,"featured_media":31815,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" admin_label=\"section\" _builder_version=\"4.16\" global_colors_info=\"{}\" theme_builder_area=\"post_content\"][et_pb_row admin_label=\"row\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_padding=\"|||0px||\" global_colors_info=\"{}\" theme_builder_area=\"post_content\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" custom_padding__hover=\"|||\" theme_builder_area=\"post_content\"][et_pb_text admin_label=\"Text\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" global_colors_info=\"{}\" theme_builder_area=\"post_content\"]

The first patient was recently treated in the AMELIE clinical trial during April 2026. The team at The Royal London Hospital implanted healthy muscle cells attached to microscopic beads in humans for the first time. The study aims to treat faecal incontinence caused by childbirth injury.<\/span><\/p>\n

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The first patients had been biopsied two weeks prior to this in Cardiff at the University Hospital of Wales.<\/p>\n

These are important milestones for the progression of this groundbreaking treatment. The team looks forward to treating the remaining patients enrolled in the trial in the coming months.<\/p>\n<\/div>\n

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