{"id":31818,"date":"2026-07-02T09:56:49","date_gmt":"2026-07-02T09:56:49","guid":{"rendered":"https:\/\/amelie-project.eu\/?page_id=31818"},"modified":"2026-07-02T09:56:52","modified_gmt":"2026-07-02T09:56:52","slug":"incontinenza-fecale-in-europa-prevalenza-e-cause-principali","status":"publish","type":"page","link":"https:\/\/amelie-project.eu\/it\/incontinenza-fecale-in-europa-prevalenza-e-cause-principali\/","title":{"rendered":"Incontinenza fecale in Europa: prevalenza e cause principali"},"content":{"rendered":"\n[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Hero section&#8221; _builder_version=&#8221;4.16&#8243; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/AMELIEHEADERBACKGOUND-01-scaled.jpg&#8221; background_position=&#8221;center_left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;7%||7%||true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; 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header_font_size=&#8221;4vw&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_tablet=&#8221;||||false|false&#8221; custom_padding_phone=&#8221;||||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; hover_enabled=&#8221;0&#8243; header_font_size_tablet=&#8221;8vw&#8221; header_font_size_phone=&#8221;10vw&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/dsm_block_reveal_text][dsm_block_reveal_text block_reveal_text=&#8221;AND MAJOR CAUSES&#8221; block_reveal_color=&#8221;#0e94f9&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;AMELIE||||||||&#8221; header_text_color=&#8221;#0e94f9&#8243; header_font_size=&#8221;3vw&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_tablet=&#8221;||||false|false&#8221; custom_padding_phone=&#8221;||||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; hover_enabled=&#8221;0&#8243; header_font_size_tablet=&#8221;6vw&#8221; header_font_size_phone=&#8221;7vw&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/dsm_block_reveal_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.16&#8243; transform_scale_tablet=&#8221;90%|90%&#8221; transform_scale_last_edited=&#8221;off|desktop&#8221; transform_translate_last_edited=&#8221;off|desktop&#8221; transform_rotate_last_edited=&#8221;off|desktop&#8221; transform_skew_last_edited=&#8221;off|desktop&#8221; transform_origin_last_edited=&#8221;off|desktop&#8221; transform_styles_last_edited=&#8221;off|desktop&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;100px|0px|100px|0px&#8221; custom_padding_tablet=&#8221;35px|0px|35px|0px|true|false&#8221; custom_padding_phone=&#8221;15px||15px||true|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_slide=&#8221;11%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_tilt_image src=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science1shadow-4.png&#8221; title_text=&#8221;science1shadow&#8221; dsm_tilt_mobile=&#8221;on&#8221; dsm_tilt_scale=&#8221;1.1&#8243; dsm_tilt_max=&#8221;15&#8243; dsm_use_glare=&#8221;on&#8221; dsm_tilt_glare=&#8221;0.5&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_tilt_image][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;15px&#8221; header_letter_spacing=&#8221;1px&#8221; header_line_height=&#8221;1.4em&#8221; header_2_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;15px&#8221; header_2_letter_spacing=&#8221;1px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;15px&#8221; header_3_letter_spacing=&#8221;1px&#8221; header_3_line_height=&#8221;1.4em&#8221; header_4_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_4_text_color=&#8221;#000000&#8243; header_4_font_size=&#8221;17px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.4em&#8221; header_5_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_5_text_color=&#8221;#000000&#8243; header_5_font_size=&#8221;15px&#8221; header_5_letter_spacing=&#8221;1px&#8221; header_5_line_height=&#8221;1.4em&#8221; header_6_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_6_text_color=&#8221;#000000&#8243; header_6_font_size=&#8221;15px&#8221; header_6_letter_spacing=&#8221;1px&#8221; header_6_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;800px&#8221; module_alignment=&#8221;center&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>Faecal incontinence is common but underreported, and can <strong>significantly impact quality of life<\/strong>, social functioning, and healthcare utilisation<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_tilt_image src=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science2shadow.png&#8221; title_text=&#8221;science2shadow&#8221; dsm_tilt_mobile=&#8221;on&#8221; dsm_tilt_scale=&#8221;1.1&#8243; dsm_tilt_max=&#8221;15&#8243; dsm_use_glare=&#8221;on&#8221; dsm_tilt_glare=&#8221;0.5&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_tilt_image][et_pb_text _builder_version=&#8221;4.27.4&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;15px&#8221; header_letter_spacing=&#8221;1px&#8221; header_line_height=&#8221;1.4em&#8221; header_2_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;15px&#8221; header_2_letter_spacing=&#8221;1px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;15px&#8221; header_3_letter_spacing=&#8221;1px&#8221; header_3_line_height=&#8221;1.4em&#8221; header_4_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_4_text_color=&#8221;#000000&#8243; header_4_font_size=&#8221;17px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.4em&#8221; header_5_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_5_text_color=&#8221;#000000&#8243; header_5_font_size=&#8221;15px&#8221; header_5_letter_spacing=&#8221;1px&#8221; header_5_line_height=&#8221;1.4em&#8221; header_6_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_6_text_color=&#8221;#000000&#8243; header_6_font_size=&#8221;15px&#8221; header_6_letter_spacing=&#8221;1px&#8221; header_6_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;800px&#8221; module_alignment=&#8221;center&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<p>It is thought that 6.5% of Europe (9.1% of women and 7.4% of men) live with faecal incontinence &#8211; that&#8217;s <strong>48 million people<\/strong><\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_tilt_image src=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science3shadow-2.png&#8221; title_text=&#8221;science3shadow&#8221; dsm_tilt_mobile=&#8221;on&#8221; dsm_tilt_scale=&#8221;1.1&#8243; dsm_tilt_max=&#8221;15&#8243; dsm_use_glare=&#8221;on&#8221; dsm_tilt_glare=&#8221;0.5&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_tilt_image][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;15px&#8221; header_letter_spacing=&#8221;1px&#8221; header_line_height=&#8221;1.4em&#8221; header_2_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;15px&#8221; header_2_letter_spacing=&#8221;1px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;15px&#8221; header_3_letter_spacing=&#8221;1px&#8221; header_3_line_height=&#8221;1.4em&#8221; header_4_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_4_text_color=&#8221;#000000&#8243; header_4_font_size=&#8221;17px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.4em&#8221; header_5_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_5_text_color=&#8221;#000000&#8243; header_5_font_size=&#8221;15px&#8221; header_5_letter_spacing=&#8221;1px&#8221; header_5_line_height=&#8221;1.4em&#8221; header_6_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_6_text_color=&#8221;#000000&#8243; header_6_font_size=&#8221;15px&#8221; header_6_letter_spacing=&#8221;1px&#8221; header_6_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;800px&#8221; module_alignment=&#8221;center&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>Faecal incontinence may be caused by <strong>obstetric anal sphincter injury, ageing, colorectal cancer, neurological disease, chronic diarrhoea and other bowel disorders, or previous surgeries<\/strong><\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(0,0,0,0.03)&#8221; background_position=&#8221;top_center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;100px||100px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;4&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;0px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; parallax__hover=&#8221;off&#8221; parallax_method__hover=&#8221;on&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;How many people in Europe are affected?&#8221; url=&#8221;#&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;64px&#8221; content_max_width=&#8221;1400px&#8221; admin_label=&#8221;Chapter&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_line_height=&#8221;1.5em&#8221; body_font=&#8221;Gotham kinda bold||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.9em&#8221; background_color=&#8221;#ffffff&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;30px|40px|30px|40px&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_zoom=&#8221;20%&#8221; animation_starting_opacity=&#8221;100%&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;60px&#8221; box_shadow_color=&#8221;rgba(10,3,3,0.06)&#8221; image_max_width=&#8221;64px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">\n<p>Faecal incontinence (FI) is a common but underreported condition that significantly impacts quality of life, social functioning, and healthcare utilisation.<\/p>\n<p>The strongest recent evidence comes from a 2024 systematic review and meta-analysis of 80 studies involving more than 548,000 adults worldwide <a href=\"https:\/\/www.cghjournal.org\/article\/S1542-3565(23)00715-2\/fulltext\">(Mack et al, 2024)<\/a>:<\/p>\n<ul>\n<li>Overall prevalence of FI in community-dwelling adults: <strong>8.0%<\/strong><\/li>\n<li>Women: <strong>9.1%<\/strong><\/li>\n<li>Men: <strong>7.4%<\/strong><\/li>\n<li>Sensitivity analyses revealed that the prevalence of FI in Europe is 6.5%<\/li>\n<li>Applying these prevalence estimates to Europe&#8217;s population (~743 million people) suggests around 48 million people in Europe are living with FI.<\/li>\n<\/ul>\n<\/div>[\/et_pb_blurb][et_pb_blurb title=&#8221;What causes faecal incontinence?&#8221; url=&#8221;#&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;64px&#8221; content_max_width=&#8221;1400px&#8221; admin_label=&#8221;Chapter&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_line_height=&#8221;1.5em&#8221; body_font=&#8221;Gotham kinda bold||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.9em&#8221; background_color=&#8221;#ffffff&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;30px|40px|30px|40px&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_zoom=&#8221;20%&#8221; animation_starting_opacity=&#8221;100%&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;60px&#8221; box_shadow_color=&#8221;rgba(10,3,3,0.06)&#8221; image_max_width=&#8221;64px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>There is currently no robust Europe-wide dataset that attributes every case of FI to a specific cause. However, the literature consistently identifies the following major aetiological groups.<\/p>\n<ol>\n<li><strong> Obstetric Anal Sphincter Injury (OASI)<\/strong><\/li>\n<\/ol>\n<p>Obstetric injury is widely regarded as the <strong>most common identifiable cause of faecal incontinence in women<\/strong>.<\/p>\n<p>Key findings:<\/p>\n<ul>\n<li>OASI occurs in 2.9% of all vaginal deliveries in the United Kingdom, and 6% of women giving birth for the first time. <a href=\"https:\/\/www.researchgate.net\/publication\/365355927_The_incidence_of_anal_incontinence_following_obstetric_anal_sphincter_injury_OASI_graded_using_the_Sultan_classification_A_network_meta-analysis\">(Okeahialam et al, 2022)<\/a><\/li>\n<li>More than <strong>20% of women may experience anal incontinence within five years following vaginal delivery<\/strong>, although symptoms vary in severity. <a href=\"https:\/\/www.researchgate.net\/publication\/365355927_The_incidence_of_anal_incontinence_following_obstetric_anal_sphincter_injury_OASI_graded_using_the_Sultan_classification_A_network_meta-analysis\">(Okeahialam et al, 2022)<\/a><\/li>\n<\/ul>\n<ol start=\"2\">\n<li><strong> Ageing and Pelvic Floor Degeneration<\/strong><\/li>\n<\/ol>\n<p>Age is one of the strongest risk factors for FI. The 2024 meta-analysis <a href=\"https:\/\/www.cghjournal.org\/article\/S1542-3565(23)00715-2\/fulltext\">(Mack et al, 2024)<\/a> found:<\/p>\n<ul>\n<li>Adults aged \u226560 years: <strong>9.3% prevalence<\/strong><\/li>\n<li>Adults aged &lt;60 years: <strong>4.9% prevalence<\/strong><\/li>\n<\/ul>\n<p>Age-related causes include:<\/p>\n<ul>\n<li>Progressive sphincter weakness<\/li>\n<li>Reduced rectal sensation<\/li>\n<li>Pelvic floor dysfunction<\/li>\n<li>Frailty and reduced mobility<\/li>\n<\/ul>\n<p>Many experts consider age-related dysfunction to be the <strong>largest contributor to overall FI prevalence<\/strong>.<\/p>\n<ol start=\"3\">\n<li><strong> Colorectal Cancer and Cancer Treatment<\/strong><\/li>\n<\/ol>\n<p>Advances in rectal cancer treatment have increased survivorship but also increased the number of patients living with bowel dysfunction.<\/p>\n<p>Among patients undergoing sphincter-preserving rectal cancer surgery:<\/p>\n<ul>\n<li>Approximately 40% develop symptoms of Low Anterior Resection Syndrome (LARS). <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7034376\/\">(Keane et al, 2020)<\/a><\/li>\n<li>Symptoms frequently include urgency, clustering, frequency, and faecal incontinence.<\/li>\n<\/ul>\n<p>This represents one of the largest groups seen in specialist colorectal and pelvic floor services.<\/p>\n<ol start=\"4\">\n<li><strong> Neurological Disease<\/strong><\/li>\n<\/ol>\n<p>Neurological conditions can impair anorectal sensation, sphincter control, and bowel coordination. (<a href=\"https:\/\/www.nature.com\/articles\/s41572-022-00381-7\">Rao, Bharucha, et al., 2022<\/a>)<\/p>\n<p>Important causes include:<\/p>\n<ul>\n<li>Stroke<\/li>\n<li>Multiple sclerosis<\/li>\n<li>Parkinson&#8217;s disease<\/li>\n<li>Spinal cord injury<\/li>\n<li>Diabetic neuropathy<\/li>\n<\/ul>\n<p>Neurological disease is particularly important in older adults and long-term care populations.<\/p>\n<ol start=\"5\">\n<li><strong> Chronic Diarrhoea and Functional Bowel Disorders<\/strong><\/li>\n<\/ol>\n<p>Loose stool can overwhelm even an intact continence mechanism. Common associated conditions include:<\/p>\n<ul>\n<li>Irritable bowel syndrome (IBS)<\/li>\n<li>Inflammatory bowel disease (IBD)<\/li>\n<li>Bile acid diarrhoea<\/li>\n<li>Medication-induced diarrhoea<\/li>\n<\/ul>\n<p>These conditions are frequently present as either a primary cause or a major contributing factor.<\/p>\n<ol start=\"6\">\n<li><strong> Previous Anorectal Surgery and Trauma<\/strong><\/li>\n<\/ol>\n<p>A smaller but clinically important proportion of patients develop FI following:<\/p>\n<ul>\n<li>Haemorrhoid surgery<\/li>\n<li>Anal fistula surgery<\/li>\n<li>Anal dilatation procedures<\/li>\n<li>Pelvic trauma<\/li>\n<li>Other anorectal interventions<\/li>\n<\/ul>[\/et_pb_blurb][et_pb_blurb title=&#8221;References&#8221; url=&#8221;#&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;64px&#8221; content_max_width=&#8221;1400px&#8221; admin_label=&#8221;Chapter&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_line_height=&#8221;1.5em&#8221; body_font=&#8221;Gotham kinda bold||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.9em&#8221; background_color=&#8221;#ffffff&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;30px|40px|30px|40px&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_zoom=&#8221;20%&#8221; animation_starting_opacity=&#8221;100%&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;60px&#8221; box_shadow_color=&#8221;rgba(10,3,3,0.06)&#8221; image_max_width=&#8221;64px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>Mack et al. (2024). <em>Global Prevalence of Fecal Incontinence in Community-Dwelling Adults: A Systematic Review and Meta-analysis<\/em>. Neurogastroenterology &amp; Motility.<br \/><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10948379\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10948379\/<\/a><strong>\u00a0<\/strong><\/p>\n<p>Dudding TC, Vaizey CJ, Kamm MA. (2008). <em>Obstetric Anal Sphincter Injury: Incidence, Risk Factors and Management<\/em>.<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18216527\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/18216527\/<\/a><\/p>\n<p>Okeahialam NA et al. (2022). <em>Incidence of Anal Incontinence Following Obstetric Anal Sphincter Injury<\/em>.<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36379266\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36379266\/<\/a><\/p>\n<p>Rao SSC, Bharucha AE et al. (2022). <em>Faecal Incontinence<\/em>. Nature Reviews Disease Primers.<br \/><a href=\"https:\/\/www.nature.com\/articles\/s41572-022-00381-7\">https:\/\/www.nature.com\/articles\/s41572-022-00381-7<\/a><\/p>\n<p>Keane C et al. (2020). <em>International Consensus Definition of Low Anterior Resection Syndrome<\/em>.<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32027242\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32027242\/<\/a><\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module dsm_block_reveal_text dsm_block_reveal_text_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm_block_reveal_text_wrapper\" data-dsm-block-reveal-animation=\"lr\" data-dsm-block-reveal-color=\"#0e94f9\" data-dsm-block-reveal-delay=\"0\" data-dsm-block-reveal-viewport=\"80%\"><h1 class=\"dsm_block_reveal_text_header et_pb_module_header\">PREVALENCE<\/h1><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_pb_module dsm_block_reveal_text dsm_block_reveal_text_1\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm_block_reveal_text_wrapper\" data-dsm-block-reveal-animation=\"lr\" data-dsm-block-reveal-color=\"#0e94f9\" data-dsm-block-reveal-delay=\"0.1\" data-dsm-block-reveal-viewport=\"80%\"><h2 class=\"dsm_block_reveal_text_header et_pb_module_header\">AND MAJOR CAUSES<\/h2><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_pb_module dsm_tilt_image dsm_tilt_image_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm-tilt-image-wrapper\" data-tilt data-tilt-max=\"15\" data-tilt-speed=\"300\" data-tilt-perspective=\"1000\" data-tilt-scale=\"1.1\" data-tilt-mobile-disable=\"on\" data-tilt-glare data-tilt-max-glare=0.5 data-tilt-reverse=\"false\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap \"><img decoding=\"async\" src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science1shadow-4.png\" alt=\"\" title=\"science1shadow\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Faecal incontinence is common but underreported, and can significantly impact quality of life, social functioning, and healthcare utilisation<div class=\"et_pb_module dsm_tilt_image dsm_tilt_image_1\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm-tilt-image-wrapper\" data-tilt data-tilt-max=\"15\" data-tilt-speed=\"300\" data-tilt-perspective=\"1000\" data-tilt-scale=\"1.1\" data-tilt-mobile-disable=\"on\" data-tilt-glare data-tilt-max-glare=0.5 data-tilt-reverse=\"false\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap \"><img decoding=\"async\" src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science2shadow.png\" alt=\"\" title=\"science2shadow\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>It is thought that 6.5% of Europe (9.1% of women and 7.4% of men) live with faecal incontinence &#8211; that&#8217;s 48 million people<div class=\"et_pb_module dsm_tilt_image dsm_tilt_image_2\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm-tilt-image-wrapper\" data-tilt data-tilt-max=\"15\" data-tilt-speed=\"300\" data-tilt-perspective=\"1000\" data-tilt-scale=\"1.1\" data-tilt-mobile-disable=\"on\" data-tilt-glare data-tilt-max-glare=0.5 data-tilt-reverse=\"false\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap \"><img decoding=\"async\" src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science3shadow-2.png\" alt=\"\" title=\"science3shadow\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Faecal incontinence may be caused by obstetric anal sphincter injury, ageing, colorectal cancer, neurological disease, chronic diarrhoea and other bowel disorders, or previous surgeries Faecal incontinence (FI) is a common but underreported condition that significantly impacts quality of life, social functioning, and healthcare utilisation. The strongest recent evidence comes from a 2024 systematic review and meta-analysis of 80 studies involving more than 548,000 adults worldwide (Mack et al, 2024): Overall prevalence of FI in community-dwelling adults: 8.0% Women: 9.1% Men: 7.4% Sensitivity analyses revealed that the prevalence of FI in Europe is 6.5% [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" custom_padding_last_edited=\"on|phone\" disabled_on=\"off|off|off\" admin_label=\"Hero section\" _builder_version=\"4.16\" background_image=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/AMELIEHEADERBACKGOUND-01-scaled.jpg\" background_position=\"center_left\" custom_margin=\"|||\" custom_padding=\"7%||7%||true|false\" custom_padding_tablet=\"15%||15%||true|false\" custom_padding_phone=\"\" global_colors_info=\"{}\"][et_pb_row use_custom_gutter=\"on\" gutter_width=\"1\" custom_padding_last_edited=\"on|desktop\" _builder_version=\"4.16\" _module_preset=\"default\" width=\"100%\" module_alignment=\"left\" custom_padding=\"|||4%|false|false\" custom_padding_tablet=\"|||6%|false|false\" custom_padding_phone=\"|||7%|false|false\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_block_reveal_text block_reveal_text=\"BENEFITS\" heading_html_tag=\"h1\" block_reveal_color=\"#0e94f9\" block_reveal_delay=\"0\" _builder_version=\"4.16\" _module_preset=\"default\" header_font=\"AMELIE||||||||\" header_text_color=\"#0e94f9\" header_font_size=\"4vw\" custom_padding=\"||||false|false\" custom_padding_tablet=\"||||false|false\" custom_padding_phone=\"||||false|false\" custom_padding_last_edited=\"on|phone\" header_font_size_tablet=\"8vw\" header_font_size_phone=\"10vw\" header_font_size_last_edited=\"on|desktop\" global_colors_info=\"{}\"][\/dsm_block_reveal_text][dsm_block_reveal_text block_reveal_text=\"OF AMELIE\" block_reveal_color=\"#0e94f9\" _builder_version=\"4.16\" _module_preset=\"default\" header_font=\"AMELIE||||||||\" header_text_color=\"#0e94f9\" header_font_size=\"3vw\" custom_padding=\"||||false|false\" custom_padding_tablet=\"||||false|false\" custom_padding_phone=\"||||false|false\" custom_padding_last_edited=\"on|phone\" header_font_size_tablet=\"6vw\" header_font_size_phone=\"7vw\" header_font_size_last_edited=\"on|desktop\" global_colors_info=\"{}\"][\/dsm_block_reveal_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" custom_padding_last_edited=\"on|phone\" _builder_version=\"4.16\" transform_scale_tablet=\"90%|90%\" transform_scale_last_edited=\"off|desktop\" transform_translate_last_edited=\"off|desktop\" transform_rotate_last_edited=\"off|desktop\" transform_skew_last_edited=\"off|desktop\" transform_origin_last_edited=\"off|desktop\" transform_styles_last_edited=\"off|desktop\" custom_margin=\"||||false|false\" custom_padding=\"100px|0px|100px|0px\" custom_padding_tablet=\"35px|0px|35px|0px|true|false\" custom_padding_phone=\"15px||15px||true|false\" global_colors_info=\"{}\"][et_pb_row column_structure=\"1_3,1_3,1_3\" _builder_version=\"4.16\" _module_preset=\"default\" animation_style=\"slide\" animation_direction=\"bottom\" animation_intensity_slide=\"11%\" global_colors_info=\"{}\"][et_pb_column type=\"1_3\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_tilt_image src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science1shadow-4.png\" title_text=\"science1shadow\" dsm_tilt_mobile=\"on\" dsm_tilt_scale=\"1.1\" dsm_tilt_max=\"15\" dsm_use_glare=\"on\" dsm_tilt_glare=\"0.5\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/dsm_tilt_image][et_pb_text _builder_version=\"4.16\" text_font=\"Gotham kinda bold||||||||\" text_text_color=\"#000000\" text_font_size=\"16px\" text_line_height=\"1.6em\" header_font=\"Gotham kinda bold|||on|||||\" header_text_color=\"#000000\" header_font_size=\"15px\" header_letter_spacing=\"1px\" header_line_height=\"1.4em\" header_2_font=\"Gotham kinda bold|||on|||||\" header_2_text_color=\"#000000\" header_2_font_size=\"15px\" header_2_letter_spacing=\"1px\" header_2_line_height=\"1.4em\" header_3_font=\"Gotham kinda bold|||on|||||\" header_3_text_color=\"#000000\" header_3_font_size=\"15px\" header_3_letter_spacing=\"1px\" header_3_line_height=\"1.4em\" header_4_font=\"Gotham kinda bold|||on|||||\" header_4_text_color=\"#000000\" header_4_font_size=\"17px\" header_4_letter_spacing=\"1px\" header_4_line_height=\"1.4em\" header_5_font=\"Gotham kinda bold|||on|||||\" header_5_text_color=\"#000000\" header_5_font_size=\"15px\" header_5_letter_spacing=\"1px\" header_5_line_height=\"1.4em\" header_6_font=\"Gotham kinda bold|||on|||||\" header_6_text_color=\"#000000\" header_6_font_size=\"15px\" header_6_letter_spacing=\"1px\" header_6_line_height=\"1.4em\" text_orientation=\"center\" max_width=\"800px\" module_alignment=\"center\" locked=\"off\" global_colors_info=\"{}\"]<p>Potential new regenerative therapies to address unmet clinical needs of large patient groups identified.<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_tilt_image src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science2shadow.png\" title_text=\"science2shadow\" dsm_tilt_mobile=\"on\" dsm_tilt_scale=\"1.1\" dsm_tilt_max=\"15\" dsm_use_glare=\"on\" dsm_tilt_glare=\"0.5\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/dsm_tilt_image][et_pb_text _builder_version=\"4.16\" text_font=\"Gotham kinda bold||||||||\" text_text_color=\"#000000\" text_font_size=\"16px\" text_line_height=\"1.6em\" header_font=\"Gotham kinda bold|||on|||||\" header_text_color=\"#000000\" header_font_size=\"15px\" header_letter_spacing=\"1px\" header_line_height=\"1.4em\" header_2_font=\"Gotham kinda bold|||on|||||\" header_2_text_color=\"#000000\" header_2_font_size=\"15px\" header_2_letter_spacing=\"1px\" header_2_line_height=\"1.4em\" header_3_font=\"Gotham kinda bold|||on|||||\" header_3_text_color=\"#000000\" header_3_font_size=\"15px\" header_3_letter_spacing=\"1px\" header_3_line_height=\"1.4em\" header_4_font=\"Gotham kinda bold|||on|||||\" header_4_text_color=\"#000000\" header_4_font_size=\"17px\" header_4_letter_spacing=\"1px\" header_4_line_height=\"1.4em\" header_5_font=\"Gotham kinda bold|||on|||||\" header_5_text_color=\"#000000\" header_5_font_size=\"15px\" header_5_letter_spacing=\"1px\" header_5_line_height=\"1.4em\" header_6_font=\"Gotham kinda bold|||on|||||\" header_6_text_color=\"#000000\" header_6_font_size=\"15px\" header_6_letter_spacing=\"1px\" header_6_line_height=\"1.4em\" text_orientation=\"center\" max_width=\"800px\" module_alignment=\"center\" locked=\"off\" global_colors_info=\"{}\"]<p>Europe\u2019s position in translational regenerative medicine strengthened.<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_tilt_image src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science3shadow-2.png\" title_text=\"science3shadow\" dsm_tilt_mobile=\"on\" dsm_tilt_scale=\"1.1\" dsm_tilt_max=\"15\" dsm_use_glare=\"on\" dsm_tilt_glare=\"0.5\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/dsm_tilt_image][et_pb_text _builder_version=\"4.16\" text_font=\"Gotham kinda bold||||||||\" text_text_color=\"#000000\" text_font_size=\"16px\" text_line_height=\"1.6em\" header_font=\"Gotham kinda bold|||on|||||\" header_text_color=\"#000000\" header_font_size=\"15px\" header_letter_spacing=\"1px\" header_line_height=\"1.4em\" header_2_font=\"Gotham kinda bold|||on|||||\" header_2_text_color=\"#000000\" header_2_font_size=\"15px\" header_2_letter_spacing=\"1px\" header_2_line_height=\"1.4em\" header_3_font=\"Gotham kinda bold|||on|||||\" header_3_text_color=\"#000000\" header_3_font_size=\"15px\" header_3_letter_spacing=\"1px\" header_3_line_height=\"1.4em\" header_4_font=\"Gotham kinda bold|||on|||||\" header_4_text_color=\"#000000\" header_4_font_size=\"17px\" header_4_letter_spacing=\"1px\" header_4_line_height=\"1.4em\" header_5_font=\"Gotham kinda bold|||on|||||\" header_5_text_color=\"#000000\" header_5_font_size=\"15px\" header_5_letter_spacing=\"1px\" header_5_line_height=\"1.4em\" header_6_font=\"Gotham kinda bold|||on|||||\" header_6_text_color=\"#000000\" header_6_font_size=\"15px\" header_6_letter_spacing=\"1px\" header_6_line_height=\"1.4em\" text_orientation=\"center\" max_width=\"800px\" module_alignment=\"center\" locked=\"off\" global_colors_info=\"{}\"]<p>New therapies for major human diseases and conditions, and new approaches for therapy taken further in the development pipeline.<\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.16\" background_color=\"rgba(0,0,0,0.03)\" background_position=\"top_center\" custom_margin=\"|||\" custom_padding=\"100px||100px|\" global_colors_info=\"{}\"][et_pb_row use_custom_gutter=\"on\" gutter_width=\"4\" _builder_version=\"4.16\" custom_margin=\"||||false|false\" custom_padding=\"0px|||\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" parallax__hover=\"off\" parallax_method__hover=\"on\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Potential new regenerative therapies to address unmet clinical needs of large patient groups identified\" url=\"#\" icon_placement=\"left\" image_icon_width=\"64px\" content_max_width=\"1400px\" admin_label=\"Chapter\" _builder_version=\"4.16\" header_font=\"Gotham kinda bold||||||||\" header_text_color=\"#000000\" header_line_height=\"1.5em\" body_font=\"Gotham kinda bold||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.9em\" background_color=\"#ffffff\" custom_margin=\"|||\" custom_padding=\"30px|40px|30px|40px\" animation_style=\"zoom\" animation_direction=\"bottom\" animation_intensity_zoom=\"20%\" animation_starting_opacity=\"100%\" box_shadow_style=\"preset2\" box_shadow_horizontal=\"0px\" box_shadow_vertical=\"0px\" box_shadow_blur=\"60px\" box_shadow_color=\"rgba(10,3,3,0.06)\" image_max_width=\"64px\" locked=\"off\" global_colors_info=\"{}\"]<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">Faecal incontinence is a common condition affecting approximately 9% of adults in Europe. However, this figure is likely underestimated, as around 70% of individuals do not seek medical advice. Of those who do consult a healthcare professional, only a proportion pursue further treatment, and approximately half are not suitable for currently available options.<\/div>\n<div class=\"x_elementToProof\">The AMELIE approach offers several advantages over existing surgical interventions, which can carry risks such as infection, pain, and device failure or dislocation, sometimes resulting in the need for a permanent stoma. Improved continence outcomes have the potential to benefit not only patients, but also carers and individuals on nursing home waiting lists.<\/div>\n<div class=\"x_elementToProof\">If effective, treatment using implantable cell\u2013microcarrier technology could significantly improve quality of life for citizens across Europe. Presenting this therapy as a realistic option for restoring continence, rather than solely managing symptoms, may also encourage more patients to seek medical advice, thereby increasing access to treatment.<\/div>[\/et_pb_blurb][et_pb_blurb title=\"Europe\u2019s position in translational regenerative medicine strengthened \" url=\"#\" icon_placement=\"left\" image_icon_width=\"64px\" content_max_width=\"1400px\" admin_label=\"Chapter\" _builder_version=\"4.16\" header_font=\"Gotham kinda bold||||||||\" header_text_color=\"#000000\" header_line_height=\"1.5em\" body_font=\"Gotham kinda bold||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.9em\" background_color=\"#ffffff\" custom_margin=\"|||\" custom_padding=\"30px|40px|30px|40px\" animation_style=\"zoom\" animation_direction=\"bottom\" animation_intensity_zoom=\"20%\" animation_starting_opacity=\"100%\" box_shadow_style=\"preset2\" box_shadow_horizontal=\"0px\" box_shadow_vertical=\"0px\" box_shadow_blur=\"60px\" box_shadow_color=\"rgba(10,3,3,0.06)\" image_max_width=\"64px\" locked=\"off\" global_colors_info=\"{}\"]<p><span style=\"font-weight: 400;\">Europe is world-leading in cell-based therapies for patients with FI.<\/span> <span style=\"font-weight: 400;\">As well as reinforcing Europe\u2019s dominant role in the field, AMELIE also represents a step-change in the approach being taken to manufacture and deliver cell-based medicine that will enable European citizens to be the first worldwide to benefit from a pioneering new approach to regenerative medicine.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cell therapy is a rapidly growing area of research. Tissue engineered products are set to grow significantly and provide substantial opportunities to strengthen Europe\u2019s position in translational regenerative medicine. Europe is responsible for approximately 26% of global regenerative medicine companies. The development of innovative technology such as implantable TIPS microcarriers will draw investment to Europe. AMELIE then seeks to advance the competitive positions of European companies as providers of innovative enabling technologies for regenerative medicine. This will enhance AMELIE\u2019s exploitative potential.<\/span><\/p>[\/et_pb_blurb][et_pb_blurb title=\"New therapies for major human diseases and conditions, and new approaches for therapy taken further in the development pipeline\" url=\"#\" icon_placement=\"left\" image_icon_width=\"64px\" content_max_width=\"1400px\" admin_label=\"Chapter\" _builder_version=\"4.16\" header_font=\"Gotham kinda bold||||||||\" header_text_color=\"#000000\" header_line_height=\"1.5em\" body_font=\"Gotham kinda bold||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.9em\" background_color=\"#ffffff\" custom_margin=\"|||\" custom_padding=\"30px|40px|30px|40px\" animation_style=\"zoom\" animation_direction=\"bottom\" animation_intensity_zoom=\"20%\" animation_starting_opacity=\"100%\" box_shadow_style=\"preset2\" box_shadow_horizontal=\"0px\" box_shadow_vertical=\"0px\" box_shadow_blur=\"60px\" box_shadow_color=\"rgba(10,3,3,0.06)\" image_max_width=\"64px\" locked=\"off\" global_colors_info=\"{}\"]<p><span style=\"font-weight: 400;\">AMELIE paves the way for identical or similar innovative treatments using ASMDC cell-microcarrier combinations for a variety of other clinical conditions associated with loss of skeletal muscle function, such as urinary incontinence, muscular dystrophies and volumetric muscle loss associated with trauma injury.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The same scientific rationale and new approach developed in AMELIE is equally applicable to other anchorage-dependent cell types investigated as new regenerative medicine treatments. New products comprised of these anchorage-dependent cells are intended to treat some of the most debilitating diseases that affect muscle, bone, cartilage, ocular, heart\/cardiovascular, gastrointestinal\/liver, kidney, immune and respiratory tissues. Adoption of the implantable TIPS microcarrier technology could have a significant impact on their outcome.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Meanwhile the scale-up manufacturing process for TIPS microparticles developed can be applied to other uses of the microparticle technology currently being investigated in the development pipeline. <\/span><\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_section]","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-31818","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/pages\/31818","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/comments?post=31818"}],"version-history":[{"count":8,"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/pages\/31818\/revisions"}],"predecessor-version":[{"id":31830,"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/pages\/31818\/revisions\/31830"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/media?parent=31818"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}