{"id":30450,"date":"2020-12-16T16:08:01","date_gmt":"2020-12-16T16:08:01","guid":{"rendered":"https:\/\/amelie-project.eu\/?page_id=30450"},"modified":"2026-07-01T10:12:20","modified_gmt":"2026-07-01T10:12:20","slug":"la-nostra-ricerca","status":"publish","type":"page","link":"https:\/\/amelie-project.eu\/it\/la-nostra-ricerca\/","title":{"rendered":"La nostra ricerca"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Hero section&#8221; _builder_version=&#8221;4.16&#8243; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/AMELIEHEADERBACKGOUND-01-scaled.jpg&#8221; background_position=&#8221;center_left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;7%||7%||true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; module_alignment=&#8221;left&#8221; custom_padding=&#8221;|||4%|false|false&#8221; custom_padding_tablet=&#8221;|||5%|false|false&#8221; custom_padding_phone=&#8221;|||5.5%|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_block_reveal_text block_reveal_text=&#8221;OUR RESEARCH&#8221; heading_html_tag=&#8221;h1&#8243; block_reveal_color=&#8221;#0e94f9&#8243; block_reveal_delay=&#8221;0&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;AMELIE||||||||&#8221; header_text_color=&#8221;#0e94f9&#8243; header_font_size=&#8221;3vw&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_tablet=&#8221;||||false|false&#8221; custom_padding_phone=&#8221;||||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; header_font_size_tablet=&#8221;5vw&#8221; header_font_size_phone=&#8221;6vw&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_block_reveal_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; admin_label=&#8221;Collections&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;100px|0px|100px|0px|false|false&#8221; custom_padding_tablet=&#8221;50px||50px||true|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; make_equal=&#8221;on&#8221; custom_padding_last_edited=&#8221;off|tablet&#8221; module_id=&#8221;faecal-incontinence-about-the-condition&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_margin_tablet=&#8221;||||false|false&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|tablet&#8221; custom_padding=&#8221;0px||0px|&#8221; box_shadow_style=&#8221;preset3&#8243; box_shadow_vertical=&#8221;40px&#8221; box_shadow_blur=&#8221;50px&#8221; box_shadow_color=&#8221;rgba(0,0,0,0.1)&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_direction=&#8221;35deg&#8221; background_color_gradient_stops=&#8221;#6bc8ff 0%|#99afff 100%&#8221; background_color_gradient_start=&#8221;#6bc8ff&#8221; background_color_gradient_end=&#8221;#99afff&#8221; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/12\/Asset-1.png&#8221; custom_padding=&#8221;5%|5%|5%|5%|true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;40px|40px|40px|40px&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;AMELIE||||||||&#8221; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_3_font=&#8221;Gotham kinda bold||||||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;28px&#8221; header_3_line_height=&#8221;1.5em&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||10px|&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Incontinenza fecale: impatto sui pazienti<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.9em&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">L'incontinenza fecale rappresenta un grave problema di salute pubblica. <\/span>Questa condizione pu\u00f2 influire gravemente sulla vita quotidiana, in particolare:<\/p>\n<ul>\n<li>dignit\u00e0 e sicurezza<\/li>\n<li>benessere e salute mentale<\/li>\n<li>indipendenza<\/li>\n<\/ul>\n<div class=\"x_elementToProof\">Molte persone provano:<\/div>\n<ul>\n<li>ansia<\/li>\n<li>isolamento sociale<\/li>\n<li>riduzione della partecipazione al mondo del lavoro e agli spostamenti<\/li>\n<li>limitazioni nelle attivit\u00e0 quotidiane<\/li>\n<\/ul>\n<div class=\"x_elementToProof\">Il progetto AMELIE si concentra in particolare sull\u2019incontinenza fecale derivante da una lesione dello sfintere anale, che si verifica pi\u00f9 comunemente in seguito a:<\/div>\n<ul>\n<li>parto<\/li>\n<li>intervento chirurgico<\/li>\n<li>trauma<\/li>\n<\/ul>\n<div class=\"x_elementToProof\">Le donne che hanno partorito rappresentano una percentuale significativa delle persone colpite, con circa 5,5% che subiscono lesioni dirette durante il parto a causa di lacerazioni perineali.<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|tablet&#8221; admin_label=&#8221;Collections&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;0px|0px|100px|0px|false|false&#8221; custom_padding_tablet=&#8221;||50px||false|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;3_5,2_5&#8243; make_equal=&#8221;on&#8221; module_id=&#8221;faecal-incontinence-and-regenerative-medicine&#8221; _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;0px||0px|&#8221; hover_enabled=&#8221;0&#8243; box_shadow_style=&#8221;preset3&#8243; box_shadow_vertical=&#8221;40px&#8221; box_shadow_blur=&#8221;50px&#8221; box_shadow_color=&#8221;rgba(0,0,0,0.1)&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_column type=&#8221;3_5&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;40px|40px|40px|40px&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; custom_css_main_element_last_edited=&#8221;off|phone&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;AMELIE||||||||&#8221; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_3_font=&#8221;Gotham kinda bold||||||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;28px&#8221; header_3_line_height=&#8221;1.5em&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||10px|&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Incontinenza fecale e medicina rigenerativa<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.9em&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">\n<p>La medicina rigenerativa mira a riparare o sostituire i tessuti danneggiati dall\u2019invecchiamento, dalle malattie o da lesioni, offrendo nuove possibilit\u00e0 per il trattamento dell\u2019incontinenza fecale causata da una lesione dello sfintere anale. Tra gli approcci rigenerativi, la terapia cellulare che utilizza cellule autologhe derivate dal muscolo scheletrico (ASMDC) per rigenerare lo sfintere anale esterno danneggiato \u00e8 stata quella oggetto delle ricerche pi\u00f9 approfondite.<\/p>\n<\/div>\n<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\"><\/div>\n<div class=\"x_elementToProof\">L\u2019Europa ha svolto un ruolo di primo piano nel tradurre questo approccio nella pratica clinica. Dei cinque studi clinici pubblicati sulla terapia cellulare per l\u2019incontinenza fecale, tre sono stati condotti da gruppi di ricerca europei e hanno utilizzato ASMDC somministrate sotto forma di sospensione cellulare. Nello studio di fase II randomizzato e controllato con placebo, solo il 58% dei pazienti sottoposti alla terapia con ASMDC ha risposto al trattamento dopo 12 mesi, mentre studi pilota in aperto hanno riportato livelli simili di miglioramento soggettivo. Nel complesso, questi studi hanno dimostrato solo un modesto beneficio clinico, suggerendo che gli attuali metodi di somministrazione cellulare non raggiungono in modo coerente l\u2019effetto terapeutico desiderato.<\/div>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_direction=&#8221;35deg&#8221; background_color_gradient_stops=&#8221;#6bc8ff 0%|#99afff 100%&#8221; background_color_gradient_start=&#8221;#6bc8ff&#8221; background_color_gradient_end=&#8221;#99afff&#8221; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/12\/Asset-3.png&#8221; custom_padding=&#8221;5%|5%|5%|5%|true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; custom_css_main_element_last_edited=&#8221;off|desktop&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|tablet&#8221; admin_label=&#8221;Collections&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;0px|0px|100px|0px|false|false&#8221; custom_padding_tablet=&#8221;||100px||false|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; make_equal=&#8221;on&#8221; module_id=&#8221;why-are-conventional-methods-not-working&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;0px||0px|&#8221; box_shadow_style=&#8221;preset3&#8243; box_shadow_vertical=&#8221;40px&#8221; box_shadow_blur=&#8221;50px&#8221; box_shadow_color=&#8221;rgba(0,0,0,0.1)&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_direction=&#8221;35deg&#8221; background_color_gradient_stops=&#8221;#6bc8ff 0%|#99afff 100%&#8221; background_color_gradient_start=&#8221;#6bc8ff&#8221; background_color_gradient_end=&#8221;#99afff&#8221; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/12\/Asset-2.png&#8221; custom_padding=&#8221;5%|5%|5%|5%|true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;40px|40px|40px|40px&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;AMELIE||||||||&#8221; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_3_font=&#8221;Gotham kinda bold||||||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;28px&#8221; header_3_line_height=&#8221;1.5em&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||10px|&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Perch\u00e9 i metodi convenzionali non danno risultati migliori?<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.9em&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">Molte delle cellule utilizzate nella medicina rigenerativa, comprese le cellule autologhe derivate dal muscolo scheletrico (ASMDC), sono<span>\u00a0<\/span><b>dipendente dall'ancoraggio<\/b>, il che significa che devono rimanere attaccate a una superficie per poter crescere e funzionare normalmente. Nella produzione convenzionale, queste cellule vengono isolate dal paziente, coltivate in laboratorio mentre sono attaccate a una superficie di coltura e poi staccate prima di essere somministrate sotto forma di sospensione cellulare.<\/div>\n<div class=\"x_elementToProof\">Ad oggi, tutti gli studi clinici pubblicati sulla terapia cellulare per l\u2019incontinenza fecale hanno utilizzato questo approccio di produzione convenzionale. Tuttavia, il distacco delle cellule dalla superficie di coltura prima del trapianto pu\u00f2 danneggiarle, riducendone la vitalit\u00e0 e il potenziale rigenerativo. Questo processo pu\u00f2 inoltre innescare l\u2019anoikis, una forma di morte cellulare che si verifica quando le cellule dipendenti dall\u2019ancoraggio perdono il contatto con la superficie di supporto.<\/div>\n<div class=\"x_elementToProof\">La scarsa sopravvivenza cellulare dopo il trapianto rappresenta una delle principali sfide per la medicina rigenerativa. Nel caso delle terapie che si basano sull\u2019integrazione delle cellule nel muscolo danneggiato, come i trattamenti per l\u2019incontinenza fecale, una bassa sopravvivenza cellulare pu\u00f2 limitarne l\u2019efficacia e contribuire a risultati clinici incostanti.<\/div>\n<div class=\"x_elementToProof\">Affrontare questa sfida \u00e8 al centro del progetto AMELIE. Sviluppando una terapia basata su cellule e microvettori impiantabili che consenta alle cellule di rimanere attaccate a un\u2019impalcatura di supporto durante il trapianto, il consorzio mira a migliorare la sopravvivenza cellulare, potenziare la riparazione dei tessuti e garantire risultati migliori per i pazienti.<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module dsm_block_reveal_text dsm_block_reveal_text_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm_block_reveal_text_wrapper\" data-dsm-block-reveal-animation=\"lr\" data-dsm-block-reveal-color=\"#0e94f9\" data-dsm-block-reveal-delay=\"0\" data-dsm-block-reveal-viewport=\"80%\"><h1 class=\"dsm_block_reveal_text_header et_pb_module_header\">LA NOSTRA RICERCA<\/h1><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Faecal Incontinence: Impact on PatientsFaecal incontinence is a substantial public health problem. The condition can severely affect everyday life, including: dignity and confidence wellbeing and mental health independence Many individuals experience: anxiety social isolation reduced participation in work and travel limitations in daily activities The AMELIE project focuses specifically on faecal incontinence resulting from injury to the anal sphincter, most commonly following: childbirth surgery trauma Women who have given birth represent a large proportion of affected individuals, with around 5.5% experiencing direct injury during childbirth due to perineal tearing.Faecal Incontinence and Regenerative Medicine Regenerative medicine seeks to repair or replace tissue that has been damaged by ageing, disease or injury, offering new possibilities for treating faecal incontinence caused by injury to the anal sphincter. Among regenerative approaches, cell therapy using autologous skeletal muscle-derived cells (ASMDCs) to regenerate the damaged external anal sphincter has been the most extensively investigated. Europe has played a leading role in translating this approach into clinical practice. Of the five published clinical studies of cell therapy for faecal incontinence, three were conducted by European research groups and used [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-30450","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/pages\/30450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/comments?post=30450"}],"version-history":[{"count":23,"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/pages\/30450\/revisions"}],"predecessor-version":[{"id":31786,"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/pages\/30450\/revisions\/31786"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/it\/wp-json\/wp\/v2\/media?parent=30450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}