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AMELIE (A<\/strong><\/span>nchored M<\/span><\/strong>uscle cel<\/strong><\/span>ls for I<\/strong><\/span>ncontinence<\/span><\/strong>) is an innovative collaborative research project funded by the European Union\u2019s Horizon 2020 Framework Programme.<\/p>\n AMELIE is developing a regenerative therapy using a patient\u2019s own muscle cells to repair damaged or weakened sphincter muscle.<\/p>\n<\/div>\n [\/et_pb_cta][et_pb_button button_url=”#Learn-More” button_text=”LEARN MORE” _builder_version=”4.21.0″ _module_preset=”default” custom_button=”on” button_text_size=”12px” button_text_color=”#ffffff” button_bg_color=”#0076C3″ button_border_width=”0px” button_border_color=”#0c71c3″ button_border_radius=”5px” button_letter_spacing=”2px” button_font=”Gotham kinda bold|600||on|||||” button_icon_color=”rgba(255,255,255,0)” button_on_hover=”off” background_layout=”dark” custom_margin=”0px||0px||false|false” custom_padding=”12px|20px|12px|20px|false|false” 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AMELIE is primarily concerned with the effect of injury to the anal sphincter by childbirth, surgery or trauma. Many such patients are unsuitable for current surgical options. 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There will be opportunities to help shape the research, take part in focus groups and surveys, read materials and assist in patient recruitment to clinical trials.<\/span><\/p>\n [\/et_pb_text][et_pb_button button_url=”\/contact” button_text=”LEARN MORE” button_alignment_tablet=”center” button_alignment_phone=”” button_alignment_last_edited=”on|tablet” _builder_version=”4.27.4″ _module_preset=”b3719a75-4a2e-4427-9fcf-d8c04c1f3982″ button_text_size=”14px” button_font=”Gotham kinda bold|600||on|||||” button_icon=”$||divi||400″ button_on_hover=”on” button_letter_spacing_hover=”1px” locked=”off” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” custom_css_main_element=”margin: auto;” global_colors_info=”{}” custom_padding__hover=”|||” custom_css_main_element_last_edited=”on|phone” custom_css_main_element_tablet=”order: 1;” custom_css_main_element_phone=”order: 1;”][et_pb_video src=”https:\/\/www.youtube.com\/watch?v=figrg3PRdO4″ play_icon_color=”#000000″ use_icon_font_size=”on” thumbnail_overlay_color=”rgba(0,0,0,0.6)” _builder_version=”4.21.0″ _module_preset=”default” width=”58vh” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” module_alignment=”right” custom_margin=”||||false|false” custom_padding=”||||false|false” module_alignment_tablet=”center” module_alignment_phone=”center” module_alignment_last_edited=”on|phone” global_colors_info=”{}” play_icon_color__hover_enabled=”on|hover” play_icon_color__hover=”#000000″][\/et_pb_video][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/amelie-project.eu\/wp-content\/uploads\/2026\/07\/AMELIE-Timeline-updated-220726.png” title_text=”AMELIE Timeline updated 220726″ align=”center” _builder_version=”4.27.4″ _module_preset=”default” border_radii=”on|15px|15px|15px|15px” border_width_top=”18px” border_color_top=”#0C71C3″ box_shadow_style=”preset1″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Testimonial” _builder_version=”4.16″ custom_padding=”28px||101px|||” disabled=”on” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”1440px” custom_margin=”3.8%|auto||auto|false|false” custom_padding=”|40px||40px” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”6%” animation_starting_opacity=”100%” border_radii=”on|15px|15px|15px|15px” border_color_all=”#0076C3″ border_width_top=”18px” border_color_top=”#0076c3″ box_shadow_style=”preset3″ box_shadow_vertical=”39px” box_shadow_blur=”80px” box_shadow_color=”rgba(0,0,0,0.1)” use_custom_width=”on” custom_width_px=”1440px” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_testimonial author=”Diana Davis” job_title=”Happy Buyer” portrait_url=”https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/portrait-square-07.jpg” quote_icon=”off” _builder_version=”4.16″ body_font=”Lato||on||||||” body_text_color=”#898f99″ body_font_size=”20px” body_line_height=”2em” use_background_color=”off” custom_margin=”||60px|” box_shadow_style_image=”preset3″ box_shadow_color_image=”rgba(0,0,0,0.14)” global_colors_info=”{}”]”Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. 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animation=”off” link_option_url=”\/our-research#faecal-incontinence-about-the-condition” border_radii=”on|15px|15px|15px|15px” border_radii_image=”on|100%|100%|100%|100%” box_shadow_style=”preset2″ box_shadow_horizontal=”0px” box_shadow_blur=”54px” box_shadow_spread=”-2px” box_shadow_color=”rgba(0,0,0,0.04)” icon_font_size=”40px” use_circle=”on” circle_color=”#0076c3″ global_colors_info=”{}” box_shadow_spread__hover=”13px” box_shadow_spread__hover_enabled=”on|desktop” image_icon_background_color__sticky_enabled=”#424242″ image_icon_background_color__sticky=”#424242″]<\/p>\n Faecal Incontinence: <\/span>About The Condition<\/span><\/p>\n [\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb use_icon=”on” font_icon=”||divi||400″ icon_color=”#ffffff” image_icon_background_color=”#0076c3″ image_icon_width=”40px” _builder_version=”4.16″ header_font=”Gotham kinda bold|||on|||||” header_text_color=”#000000″ header_font_size=”15px” header_letter_spacing=”1px” header_line_height=”1.4em” body_font=”Gotham kinda bold|100|||||||” body_text_color=”#000000″ body_line_height=”1.6em” image_icon_custom_padding=”25px|25px|25px|25px|false|false” text_orientation=”center” height=”280px” height_tablet=”” height_phone=”” height_last_edited=”on|desktop” custom_margin=”|||” custom_padding=”60px|40px|60px|40px” animation=”off” link_option_url=”\/our-research#faecal-incontinence-and-regenerative-medicine” border_radii=”on|15px|15px|15px|15px” border_radii_image=”on|100%|100%|100%|100%” box_shadow_style=”preset2″ box_shadow_horizontal=”0px” box_shadow_blur=”54px” box_shadow_spread=”-2px” box_shadow_color=”rgba(0,0,0,0.04)” icon_font_size=”40px” use_circle=”on” circle_color=”#0076c3″ global_colors_info=”{}” box_shadow_spread__hover_enabled=”on|desktop” box_shadow_spread__hover=”13px” image_icon_background_color__sticky_enabled=”#424242″ image_icon_background_color__sticky=”#424242″]<\/p>\n Faecal Incontinence and Regenerative Medicine<\/span><\/p>\n [\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb use_icon=”on” font_icon=”||divi||400″ icon_color=”#ffffff” image_icon_background_color=”#0076c3″ image_icon_width=”40px” _builder_version=”4.16″ header_font=”Gotham kinda bold|||on|||||” header_text_color=”#000000″ header_font_size=”15px” header_letter_spacing=”1px” header_line_height=”1.4em” body_font=”Gotham kinda bold|100|||||||” body_text_color=”#000000″ body_line_height=”1.6em” image_icon_custom_padding=”25px|25px|25px|25px|false|false” text_orientation=”center” height=”280px” height_tablet=”” height_phone=”” height_last_edited=”on|tablet” custom_margin=”|||” custom_padding=”60px|40px|60px|40px” animation=”off” link_option_url=”\/our-research#why-are-conventional-methods-not-working” 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These cells are attached to biodegradable microcarriers, which:<\/div>\n\n
\n\nAMELIE brings together 13 partner organisations from nine countries, combining expertise from academia, healthcare, industry, and research to develop new treatments for people living with faecal incontinence.<\/div>\n<\/div>\nThe project is coordinated by University College London (UCL) and led by Professor Richard Day, Professor of Regenerative Medicine Technology at UCL<\/div>\nCan cell therapy restore muscle function?<\/h3>\n
Our Partners<\/h3>\n
Our Research<\/h3>\n
The AMELIE project brings together a highly interdisciplinary consortium of experts to develop a novel regenerative intervention using autologous skeletal muscle-derived cells to restore sphincter muscle function. In this approach, autologous skeletal muscle-derived cells are attached to implantable microcarriers to enhance cell delivery and engraftment in patients with faecal incontinence.<\/div>\nThe therapy will be evaluated in a randomised clinical trial. It is anticipated that this strategy will improve cell viability, increase the likelihood of muscle regeneration, and ultimately contribute to improved continence outcomes.<\/div>\nGet Involved<\/h3>\n
\n[\/et_pb_testimonial][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_testimonial author=”Jessica Bowen” job_title=”Happy Renter” portrait_url=”https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/portrait-square-08.jpg” quote_icon=”off” _builder_version=”4.16″ body_font=”Lato||on||||||” body_text_color=”#898f99″ body_font_size=”20px” body_line_height=”2em” use_background_color=”off” custom_margin=”||60px|” box_shadow_style_image=”preset3″ box_shadow_color_image=”rgba(0,0,0,0.14)” locked=”off” global_colors_info=”{}”]”Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat.
\n[\/et_pb_testimonial][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Features” _builder_version=”4.16″ custom_padding=”80px|0px|80px|0px|false|false” disabled=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_margin=”|||” custom_padding=”0px||0px|||” border_color_all=”#0076C3″ border_color_top=”#0076c3″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Gotham kinda bold||||||||” text_font_size=”16px” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”Gotham kinda bold||||||||” header_2_text_color=”#000000″ header_2_font_size=”32px” header_2_line_height=”1.5em” header_3_font=”Gotham kinda bold||||||||” text_orientation=”center” max_width=”800px” module_alignment=”center” locked=”off” global_colors_info=”{}”]<\/p>\nThe Science Behind AMELIE<\/h2>\n
Ready to get started?<\/h2>\n
Ready to learn more?<\/h2>\n
Ready to get started?<\/h2>\n
\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\tAMELIE<\/h1><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>AMELIE (Anchored Muscle cells for Incontinence) \u00e8 un innovativo progetto di ricerca collaborativo finanziato dal programma quadro \u201cOrizzonte 2020\u201d dell\u2019Unione Europea. AMELIE sta sviluppando una terapia rigenerativa che utilizza le cellule muscolari del paziente stesso per riparare il muscolo sfintere danneggiato o indebolito.
\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t![\"\"](\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2026\/07\/amelie-cells.jpg\" "\\"cellule")
<\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Cosa facciamo: Offriamo una terapia cellulare di lunga durata e minimamente invasiva e di lunga durata. Queste cellule sono fissate a microvettori biodegradabili che: favoriscono la sopravvivenza cellulare, stimolano la rigenerazione dei tessuti e migliorano il rilascio della terapia nell\u2019area interessata. Sfruttando la naturale capacit\u00e0 di autoriparazione dell\u2019organismo, AMELIE mira a offrire un trattamento di lunga durata e minimamente invasivo per l\u2019incontinenza fecale. La tecnologia presenta inoltre potenziali applicazioni in altre lesioni muscolari e patologie che vanno oltre la salute intestinale. AMELIE riunisce 13 organizzazioni partner provenienti da nove paesi, combinando competenze provenienti dal mondo accademico, sanitario, industriale e della ricerca per sviluppare nuovi trattamenti per le persone affette da incontinenza fecale. Il progetto \u00e8 coordinato dall\u2019University College London (UCL) e guidato dal professor Richard Day, titolare della cattedra di Tecnologia della Medicina Rigenerativa presso l\u2019UCL\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t![\"\"](\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2026\/02\/05-VC-Cafe-London-260226-Copy-1080x675.jpg\")
\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tIn rappresentanza del progetto AMELIE al Summit sull\u2019innovazione chirurgica 2026 della Cleveland Clinic<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t\t\t<\/header>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t