{"id":31500,"date":"2025-04-16T09:25:41","date_gmt":"2025-04-16T09:25:41","guid":{"rendered":"https:\/\/amelie-project.eu\/?post_type=publication&p=31500"},"modified":"2025-04-16T09:25:45","modified_gmt":"2025-04-16T09:25:45","slug":"un-traitement-regenerateur-pourrait-guerir-les-patients-souffrant-dincontinence","status":"publish","type":"publication","link":"https:\/\/amelie-project.eu\/fr\/publication\/un-traitement-regenerateur-pourrait-guerir-les-patients-souffrant-dincontinence\/","title":{"rendered":"Un traitement r\u00e9g\u00e9n\u00e9rateur pourrait gu\u00e9rir les patients souffrant d'incontinence"},"content":{"rendered":"[et_pb_section fb_built=\u201d1\u2033 admin_label=\u201dsection\u201d _builder_version=\u201d4.16\u2033 global_colors_info=\u201d{}\u201d][et_pb_row admin_label=\u201drow\u201d _builder_version=\u201d4.21.0\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d width=\u201d100%\u201d global_colors_info=\u201d{}\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d][et_pb_text admin_label=\u201dTexte\u201d _builder_version=\u201d4.21.0\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d global_colors_info=\u201d{}\u201d]\n

Day RM, Knowles CK<\/span>.<\/strong><\/p>\n

The Guardian journal 20 juin 2024, page 7.<\/p>\n

Introduction<\/em><\/p>\n

Les patients dont la vie est perturb\u00e9e par l'incontinence f\u00e9cale se voient offrir un nouvel espoir gr\u00e2ce \u00e0 une technologie propos\u00e9e qui pourrait permettre de gu\u00e9rir leur maladie plut\u00f4t que de la g\u00e9rer.<\/p>\n

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L'article complet est disponible ici :<\/p>\n

https:\/\/issuu.com\/mediaplanetuk\/docs\/bladder_bowel_health<\/a><\/p>\n

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Day RM, Knowles CK. The Guardian journal 20 juin 2024, page 7. Introduction Les patients dont la vie a \u00e9t\u00e9 perturb\u00e9e par l'incontinence f\u00e9cale se voient offrir un nouvel espoir gr\u00e2ce \u00e0 une technologie propos\u00e9e qui pourrait offrir un rem\u00e8de potentiel, plut\u00f4t qu'une gestion, de leur \u00e9tat. L'article complet est disponible \u00e0 l'adresse suivante : https:\/\/issuu.com\/mediaplanetuk\/docs\/bladder_bowel_health                      <\/p>","protected":false},"featured_media":31502,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\n

Charlotte Desprez, Davide Danovi, Charles H Knowles and Richard M Day.<\/p>\n\n\n\n

J. Tissue Eng. 2023;14:1\u201318.<\/p>\n\n\n\n

Abstract<\/em><\/p>\n\n\n\n

Skeletal muscle-derived cells (SMDC) hold tremendous potential for replenishing dysfunctional muscle lost due to disease or trauma. Current therapeutic usage of SMDC relies on harvesting autologous cells from muscle biopsies that are subsequently expanded in vitro before re-implantation into the patient. Heterogeneity can arise from multiple factors including quality of the starting biopsy, age and comorbidity affecting the processed SMDC. Quality attributes intended for clinical use often focus on minimum levels of myogenic cell marker expression. Such approaches do not evaluate the likelihood of SMDC to differentiate and form myofibres when implanted in vivo, which ultimately determines the likelihood of muscle regeneration. Predicting the therapeutic potency of SMDC in vitro prior to implantation is key to developing successful therapeutics in regenerative medicine and reducing implementation costs. Here, we report on the development of a novel SMDC profiling tool to examine populations of cells in vitro derived from different donors. We developed an image-based pipeline to quantify morphological features and extracted cell shape descriptors. We investigated whether these could predict heterogeneity in the formation of myotubes and correlate with the myogenic fusion index. Several of the early cell shape characteristics were found to negatively correlate with the fusion index. These included total area occupied by cells, area shape, bounding box area, compactness, equivalent diameter, minimum ferret diameter, minor axis length and perimeter of SMDC at 24 h after initiating culture. The information extracted with our approach indicates live cell imaging can detect a range of cell phenotypes based on cell-shape alone and preserving cell integrity could be used to predict propensity to form myotubes in vitro and functional tissue in vivo.<\/p>\n\n\n\n

Access the full paper here: https:\/\/pubmed.ncbi.nlm.nih.gov\/36949843\/<\/a><\/p>\n","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_links_to":"","_links_to_target":""},"categories":[43],"class_list":["post-31500","publication","type-publication","status-publish","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/publication\/31500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/types\/publication"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/media\/31502"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/media?parent=31500"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/categories?post=31500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}