{"id":31461,"date":"2023-10-09T16:23:22","date_gmt":"2023-10-09T16:23:22","guid":{"rendered":"https:\/\/amelie-project.eu\/?post_type=publication&#038;p=31461"},"modified":"2024-02-26T16:30:40","modified_gmt":"2024-02-26T16:30:40","slug":"publication-4","status":"publish","type":"publication","link":"https:\/\/amelie-project.eu\/fr\/publication\/publication-4\/","title":{"rendered":"Construire des anneaux avec des sph\u00e8res : une approche de th\u00e9rapie cellulaire pour l'incontinence"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_row _builder_version=&#8221;4.21.0&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221; width=&#8221;100%&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<!-- divi:paragraph --><\/p>\n<p><strong>Martha Gilbert, Simona \u010caputov\u00e1, Delielena Poli, Manou Kooy, Georgia Sturt, Josephine Parker et Richard M Day.<\/strong><\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p>Cell &amp; Gene Therapy Insights 2023 ; 9(10), 1293-1306.<\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p>L'incontinence f\u00e9cale est une affection tr\u00e8s r\u00e9pandue qui reste largement sous-estim\u00e9e. Elle affecte la qualit\u00e9 de vie des patients et a un impact socio-\u00e9conomique et environnemental n\u00e9gatif sur la soci\u00e9t\u00e9. Les lignes directrices actuelles en mati\u00e8re de prise en charge des patients recommandent une approche progressive du traitement de l'incontinence f\u00e9cale, depuis les options de traitement conservateur jusqu'aux options chirurgicales de premi\u00e8re et de deuxi\u00e8me intention, en passant par les options chirurgicales peu invasives. Malheureusement, les traitements conservateurs restent inefficaces et, dans de nombreux cas, les options chirurgicales ne sont pas souhaitables ou ne conviennent pas. La m\u00e9decine r\u00e9g\u00e9n\u00e9rative, et plus particuli\u00e8rement la th\u00e9rapie cellulaire, a le potentiel d'offrir un traitement curatif moins invasif, plus efficace et plus efficient. Les technologies de th\u00e9rapie cellulaire, bien qu'encore en cours de d\u00e9veloppement, peuvent am\u00e9liorer l'\u00e9tat actuel des choses dans le domaine de l'incontinence f\u00e9cale au niveau clinique, au niveau du patient et au niveau socio-\u00e9conomique. L'objectif de cet article est double. Tout d'abord, il s'agit de sensibiliser \u00e0 l'affliction silencieuse qu'est l'incontinence f\u00e9cale et \u00e0 l'impact qu'elle a sur les patients et la soci\u00e9t\u00e9. Deuxi\u00e8mement, il s'agit de positionner la th\u00e9rapie cellulaire par rapport aux approches th\u00e9rapeutiques actuelles, y compris, par exemple, la stimulation du nerf sacr\u00e9 et la sphinct\u00e9roplastie, afin de souligner son potentiel en tant qu'alternative th\u00e9rapeutique appropri\u00e9e. <\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p>Acc\u00e9der \u00e0 l'article complet ici :<\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p><a href=\"https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence\">https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence<\/a><\/p>\n<p><!-- \/divi:paragraph -->[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>Martha Gilbert, Simona \u010caputov\u00e1, Delielena Poli, Manou Kooy, Georgia Sturt, Josephine Parker and Richard M Day. Cell &amp; Gene Therapy Insights 2023; 9(10), 1293\u20131306. Fecal incontinence is a prevalent condition, that remains vastly underreported. The condition impacts the patients\u2019 quality of life and has negative socio-economic and environmental impact on the society. Current patient management guidelines recommend a stepwise approach to treating fecal incontinence, from conservative treatment options, through minimally invasive surgical options, all the way to first- and second-line surgical options. Unfortunately, the conservative treatments remain ineffective, and, in many cases, the surgical options are either not desirable or not suitable. Regenerative medicine, and specifically, cell therapy, has the potential to offer a curative treatment that is less invasive, more effective and efficient. Cell therapy technologies, while still under development, can improve the current state-of-play in the realm of fecal incontinence at the clinical, patient, and socio-economic level. The aim of this article is twofold. Firstly, it is to raise awareness about the silent affliction that fecal incontinence is and about the impact that it has on patients and society. Secondly, it is to position cell therapy, relative to the current treatment approaches, including, for example, sacral nerve stimulation [&hellip;]<\/p>","protected":false},"featured_media":31463,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<!-- wp:paragraph -->\n<p><strong>Martha Gilbert, Simona \u010caputov\u00e1, Delielena Poli, Manou Kooy, Georgia Sturt, Josephine Parker and Richard M Day.<\/strong><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Cell &amp; Gene Therapy Insights 2023; 9(10), 1293\u20131306.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Fecal incontinence is a prevalent condition, that remains vastly underreported. The condition impacts the patients\u2019 quality of life and has negative socio-economic and environmental impact on the society. Current patient management guidelines recommend a stepwise approach to treating fecal incontinence, from conservative treatment options, through minimally invasive surgical options, all the way to first- and second-line surgical options. Unfortunately, the conservative treatments remain ineffective, and, in many cases, the surgical options are either not desirable or not suitable. Regenerative medicine, and specifically, cell therapy, has the potential to offer a curative treatment that is less invasive, more effective and efficient. Cell therapy technologies, while still under development, can improve the current state-of-play in the realm of fecal incontinence at the clinical, patient, and socio-economic level. The aim of this article is twofold. Firstly, it is to raise awareness about the silent affliction that fecal incontinence is and about the impact that it has on patients and society. Secondly, it is to position cell therapy, relative to the current treatment approaches, including, for example, sacral nerve stimulation and sphincteroplasty, as to emphasize its potential to provide a suitable treatment alternative. <\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Access the full paper here:<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><a href=\"https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence\">https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence<\/a><\/p>\n<!-- \/wp:paragraph -->","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_links_to":"","_links_to_target":""},"categories":[43],"class_list":["post-31461","publication","type-publication","status-publish","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/publication\/31461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/types\/publication"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/media\/31463"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/media?parent=31461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/categories?post=31461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}