{"id":29994,"date":"2023-09-10T09:09:36","date_gmt":"2023-09-10T09:09:36","guid":{"rendered":"https:\/\/amelie-project.eu\/?post_type=category-publication&#038;p=29994"},"modified":"2024-02-26T16:22:58","modified_gmt":"2024-02-26T16:22:58","slug":"publication-3","status":"publish","type":"publication","link":"https:\/\/amelie-project.eu\/fr\/publication\/publication-3\/","title":{"rendered":"Consid\u00e9rations sur les bioproc\u00e9d\u00e9s en vue de la fabrication de cellules musculaires squelettiques et lisses th\u00e9rapeutiques"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_row _builder_version=&#8221;4.21.0&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; width=&#8221;100%&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.21.0&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<p><!-- divi:paragraph --><strong>Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral et Cl\u00e1udia L da Silva.<\/strong><\/p>\n<p>Bioengineering. 2023;10(9):1067.<\/p>\n<p><!-- divi:paragraph -->Les approches d'ing\u00e9nierie tissulaire dans le contexte musculaire repr\u00e9sentent un domaine \u00e9mergent prometteur pour relever les d\u00e9fis th\u00e9rapeutiques actuels li\u00e9s \u00e0 de multiples conditions pathologiques affectant les compartiments musculaires, soit les muscles squelettiques, soit les muscles lisses, responsables de la contraction involontaire et volontaire, respectivement. Dans cette revue, plusieurs caract\u00e9ristiques et param\u00e8tres impliqu\u00e9s dans le biotraitement des cellules musculaires sont abord\u00e9s. Le processus d'isolement des cellules est d\u00e9crit, en fonction du type de tissu (muscle lisse ou squelettique), suivi de la description des d\u00e9fis li\u00e9s \u00e0 l'utilisation de tissus de donneurs adultes et des strat\u00e9gies visant \u00e0 surmonter les obstacles pour atteindre des nombres de cellules pertinents en vue d'une application clinique. Plus pr\u00e9cis\u00e9ment, l'utilisation de cellules souches\/prog\u00e9nitrices est soulign\u00e9e comme source de cellules musculaires lisses et squelettiques pour le d\u00e9veloppement d'un produit cellulaire capable de maintenir l'identit\u00e9 et la fonctionnalit\u00e9 de la cellule cible. En outre, compte tenu de la n\u00e9cessit\u00e9 d'un bioproc\u00e9d\u00e9 robuste et rentable pour la fabrication de cellules, la combinaison de cellules musculaires avec des biomat\u00e9riaux et la n\u00e9cessit\u00e9 d'une mise \u00e0 l'\u00e9chelle en vue d'applications cliniques sont \u00e9galement abord\u00e9es.<\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph -->Acc\u00e9der \u00e0 l'article complet ici :<\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/a><\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral and Cl\u00e1udia L da Silva. Bioengineering. 2023;10(9):1067. Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle or smooth muscle, responsible for involuntary and voluntary contraction, respectively. In this review, several features and parameters involved in the bioprocessing of muscle cells are addressed. The cell isolation process is depicted, depending on the type of tissue (smooth or skeletal muscle), followed by the description of the challenges involving the use of adult donor tissue and the strategies to overcome the hurdles of reaching relevant cell numbers towards a clinical application. Specifically, the use of stem\/progenitor cells is highlighted as a source for smooth and skeletal muscle cells towards the development of a cellular product able to maintain the target cell\u2019s identity and functionality. Moreover, taking into account the need for a robust and cost-effective bioprocess for cell manufacturing, the combination of muscle cells with biomaterials and the need for scale-up envisioning clinical applications are also approached. Access the full paper here: https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/p>","protected":false},"featured_media":31459,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<!-- wp:paragraph -->\n<p><strong>Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral and Cl\u00e1udia L da Silva.<br>Bioengineering. 2023;10(9):1067.<\/strong><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle or smooth muscle, responsible for involuntary and voluntary contraction, respectively. In this review, several features and parameters involved in the bioprocessing of muscle cells are addressed. The cell isolation process is depicted, depending on the type of tissue (smooth or skeletal muscle), followed by the description of the challenges involving the use of adult donor tissue and the strategies to overcome the hurdles of reaching relevant cell numbers towards a clinical application. Specifically, the use of stem\/progenitor cells is highlighted as a source for smooth and skeletal muscle cells towards the development of a cellular product able to maintain the target cell\u2019s identity and functionality. Moreover, taking into account the need for a robust and cost-effective bioprocess for cell manufacturing, the combination of muscle cells with biomaterials and the need for scale-up envisioning clinical applications are also approached.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Access the full paper here:\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/a><\/p>\n<!-- \/wp:paragraph -->","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_links_to":"","_links_to_target":""},"categories":[43],"class_list":["post-29994","publication","type-publication","status-publish","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/publication\/29994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/types\/publication"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/media\/31459"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/media?parent=29994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/categories?post=29994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}