{"id":31818,"date":"2026-07-02T09:56:49","date_gmt":"2026-07-02T09:56:49","guid":{"rendered":"https:\/\/amelie-project.eu\/?page_id=31818"},"modified":"2026-07-02T09:56:52","modified_gmt":"2026-07-02T09:56:52","slug":"lincontinence-fecale-en-europe-prevalence-et-principales-causes","status":"publish","type":"page","link":"https:\/\/amelie-project.eu\/fr\/lincontinence-fecale-en-europe-prevalence-et-principales-causes\/","title":{"rendered":"L'incontinence f\u00e9cale en Europe : pr\u00e9valence et principales causes"},"content":{"rendered":"[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Hero section&#8221; _builder_version=&#8221;4.16&#8243; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/AMELIEHEADERBACKGOUND-01-scaled.jpg&#8221; background_position=&#8221;center_left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;7%||7%||true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; module_alignment=&#8221;left&#8221; custom_padding=&#8221;|||4%|false|false&#8221; custom_padding_tablet=&#8221;|||6%|false|false&#8221; custom_padding_phone=&#8221;|||7%|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_block_reveal_text block_reveal_text=&#8221;PREVALENCE&#8221; heading_html_tag=&#8221;h1&#8243; block_reveal_color=&#8221;#0e94f9&#8243; block_reveal_delay=&#8221;0&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;AMELIE||||||||&#8221; header_text_color=&#8221;#0e94f9&#8243; header_font_size=&#8221;4vw&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_tablet=&#8221;||||false|false&#8221; custom_padding_phone=&#8221;||||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; hover_enabled=&#8221;0&#8243; header_font_size_tablet=&#8221;8vw&#8221; header_font_size_phone=&#8221;10vw&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/dsm_block_reveal_text][dsm_block_reveal_text block_reveal_text=&#8221;AND MAJOR CAUSES&#8221; block_reveal_color=&#8221;#0e94f9&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;AMELIE||||||||&#8221; header_text_color=&#8221;#0e94f9&#8243; header_font_size=&#8221;3vw&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_tablet=&#8221;||||false|false&#8221; custom_padding_phone=&#8221;||||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; hover_enabled=&#8221;0&#8243; header_font_size_tablet=&#8221;6vw&#8221; header_font_size_phone=&#8221;7vw&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/dsm_block_reveal_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.16&#8243; transform_scale_tablet=&#8221;90%|90%&#8221; transform_scale_last_edited=&#8221;off|desktop&#8221; transform_translate_last_edited=&#8221;off|desktop&#8221; transform_rotate_last_edited=&#8221;off|desktop&#8221; transform_skew_last_edited=&#8221;off|desktop&#8221; transform_origin_last_edited=&#8221;off|desktop&#8221; transform_styles_last_edited=&#8221;off|desktop&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;100px|0px|100px|0px&#8221; custom_padding_tablet=&#8221;35px|0px|35px|0px|true|false&#8221; custom_padding_phone=&#8221;15px||15px||true|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_slide=&#8221;11%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_tilt_image src=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science1shadow-4.png&#8221; title_text=&#8221;science1shadow&#8221; dsm_tilt_mobile=&#8221;on&#8221; dsm_tilt_scale=&#8221;1.1&#8243; dsm_tilt_max=&#8221;15&#8243; dsm_use_glare=&#8221;on&#8221; dsm_tilt_glare=&#8221;0.5&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_tilt_image][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;15px&#8221; header_letter_spacing=&#8221;1px&#8221; header_line_height=&#8221;1.4em&#8221; header_2_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;15px&#8221; header_2_letter_spacing=&#8221;1px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;15px&#8221; header_3_letter_spacing=&#8221;1px&#8221; header_3_line_height=&#8221;1.4em&#8221; header_4_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_4_text_color=&#8221;#000000&#8243; header_4_font_size=&#8221;17px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.4em&#8221; header_5_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_5_text_color=&#8221;#000000&#8243; header_5_font_size=&#8221;15px&#8221; header_5_letter_spacing=&#8221;1px&#8221; header_5_line_height=&#8221;1.4em&#8221; header_6_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_6_text_color=&#8221;#000000&#8243; header_6_font_size=&#8221;15px&#8221; header_6_letter_spacing=&#8221;1px&#8221; header_6_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;800px&#8221; module_alignment=&#8221;center&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>L'incontinence f\u00e9cale est fr\u00e9quente mais sous-d\u00e9clar\u00e9e, et peut <strong>avoir un impact significatif sur la qualit\u00e9 de vie<\/strong>, le fonctionnement social et le recours aux soins de sant\u00e9<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_tilt_image src=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science2shadow.png&#8221; title_text=&#8221;science2shadow&#8221; dsm_tilt_mobile=&#8221;on&#8221; dsm_tilt_scale=&#8221;1.1&#8243; dsm_tilt_max=&#8221;15&#8243; dsm_use_glare=&#8221;on&#8221; dsm_tilt_glare=&#8221;0.5&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_tilt_image][et_pb_text _builder_version=&#8221;4.27.4&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;15px&#8221; header_letter_spacing=&#8221;1px&#8221; header_line_height=&#8221;1.4em&#8221; header_2_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;15px&#8221; header_2_letter_spacing=&#8221;1px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;15px&#8221; header_3_letter_spacing=&#8221;1px&#8221; header_3_line_height=&#8221;1.4em&#8221; header_4_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_4_text_color=&#8221;#000000&#8243; header_4_font_size=&#8221;17px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.4em&#8221; header_5_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_5_text_color=&#8221;#000000&#8243; header_5_font_size=&#8221;15px&#8221; header_5_letter_spacing=&#8221;1px&#8221; header_5_line_height=&#8221;1.4em&#8221; header_6_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_6_text_color=&#8221;#000000&#8243; header_6_font_size=&#8221;15px&#8221; header_6_letter_spacing=&#8221;1px&#8221; header_6_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;800px&#8221; module_alignment=&#8221;center&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<p>On estime que 6,51 TP3T de la population europ\u00e9enne (9,11 TP3T de femmes et 7,41 TP3T d'hommes) souffrent d'incontinence f\u00e9cale \u2013 soit <strong>48 millions de personnes<\/strong><\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u201d1_3\u00a0\u201d _builder_version=\u00a0\u201d4.16\u00a0\u201d _module_preset=\u00a0\u201ddefault\u00a0\u201d global_colors_info=\u00a0\u201d{}\u00a0\u201d][dsm_tilt_image src=\u201d https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science3shadow-2.png \u201d title_text=\u201d science3shadow \u201d dsm_tilt_mobile=\u201d on \u201d dsm_tilt_scale=\u201d1.1\u201d dsm_tilt_max=\u201d15\u201d dsm_use_glare=\u201don\u201d dsm_tilt_glare=\u201d0.5\u201d _builder_version=\u201d4.16\u201d _module_preset=\u201ddefault\u201d global_colors_info=\u201d{}\u201d][\/dsm_tilt_image][et_pb_text _builder_version=\u201d4.16\u201d text_font=\u201dGotham kinda bold||||||||\u201d text_text_color=\u201d#000000\u201d text_font_size=\u201d16px\u201d text_line_height=\u201d1,6em\u201d header_font=\u201dGotham kinda bold|||on|||||\u201d header_text_color=\u201d#000000\u2033 header_font_size=\u201d15px\u201d header_letter_spacing=\u201d1px\u201d header_line_height=\u201d1.4em\u201d header_2_font=\u201dGotham kinda bold|||on|||||\u201d header_2_text_color=\u201d#000000\u2033 header_2_font_size=\u201d15px\u201d header_2_letter_spacing=\u201d1px\u201d header_2_line_height=\u201d1,4em\u201d header_3_font=\u201dGotham un peu gras|||on|||||\u201d header_3_text_color=\u201d#000000\u201d header_3_font_size=\u201d15px\u201d header_3_letter_spacing=\u201d1px\u201d header_3_line_height=\u201d1.4em\u201d header_4_font=\u201dGotham un peu gras|||on|||||\u201d header_4_text_color=\u201d#000000\u2033 header_4_font_size=\u201d17px\u201d header_4_letter_spacing=\u201d1px\u201d header_4_line_height=\u201d1.4em\u201d header_5_font=\u201dGotham un peu gras|||on|||||\u201d header_5_text_color=\u201d#000000\u201d header_5_font_size=\u201d15px\u201d header_5_letter_spacing=\u201d1px\u201d header_5_line_height=\u201d1.4em\u201d header_6_font=\u201dGotham un peu gras|||on|||||\u201d header_6_text_color=\u201d#000000\u2033 header_6_font_size=\u201d15px\u201d header_6_letter_spacing=\u201d1px\u201d header_6_line_height=\u201d1.4em\u201d text_orientation=\u00ab center \u00bb max_width=\u00ab 800px \u00bb module_alignment=\u00ab center \u00bb locked=\u00ab off \u00bb global_colors_info=\u00ab {} \u00bb]<p>L'incontinence f\u00e9cale peut \u00eatre due \u00e0 <strong>l\u00e9sion obst\u00e9tricale du sphincter anal, vieillissement, cancer colorectal, maladie neurologique, diarrh\u00e9e chronique et autres troubles intestinaux, ou ant\u00e9c\u00e9dents chirurgicaux<\/strong><\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(0,0,0,0.03)&#8221; background_position=&#8221;top_center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;100px||100px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;4&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;0px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; parallax__hover=&#8221;off&#8221; parallax_method__hover=&#8221;on&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;How many people in Europe are affected?&#8221; url=&#8221;#&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;64px&#8221; content_max_width=&#8221;1400px&#8221; admin_label=&#8221;Chapter&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_line_height=&#8221;1.5em&#8221; body_font=&#8221;Gotham kinda bold||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.9em&#8221; background_color=&#8221;#ffffff&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;30px|40px|30px|40px&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_zoom=&#8221;20%&#8221; animation_starting_opacity=&#8221;100%&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;60px&#8221; box_shadow_color=&#8221;rgba(10,3,3,0.06)&#8221; image_max_width=&#8221;64px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">\n<p>L'incontinence f\u00e9cale (IF) est une affection courante mais sous-d\u00e9clar\u00e9e qui a un impact significatif sur la qualit\u00e9 de vie, le fonctionnement social et le recours aux soins de sant\u00e9.<\/p>\n<p>Les donn\u00e9es les plus solides \u00e0 ce jour proviennent d'une revue syst\u00e9matique et d'une m\u00e9ta-analyse r\u00e9alis\u00e9es en 2024, portant sur 80 \u00e9tudes ayant port\u00e9 sur plus de 548 000 adultes \u00e0 travers le monde <a href=\"https:\/\/www.cghjournal.org\/article\/S1542-3565(23)00715-2\/fulltext\">(Mack et al., 2024)<\/a>:<\/p>\n<ul>\n<li>Pr\u00e9valence globale de l'inactivit\u00e9 physique chez les adultes vivant \u00e0 domicile : <strong>8.0%<\/strong><\/li>\n<li>Femmes : <strong>9.1%<\/strong><\/li>\n<li>Hommes : <strong>7.4%<\/strong><\/li>\n<li>Les analyses de sensibilit\u00e9 ont r\u00e9v\u00e9l\u00e9 que la pr\u00e9valence de la FI en Europe est de 6,51 TP3T<\/li>\n<li>Si l'on applique ces estimations de pr\u00e9valence \u00e0 la population europ\u00e9enne (environ 743 millions de personnes), on peut estimer qu'environ 48 millions de personnes en Europe sont atteintes de FI.<\/li>\n<\/ul>\n<\/div>[\/et_pb_blurb][et_pb_blurb title=&#8221;What causes faecal incontinence?&#8221; url=&#8221;#&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;64px&#8221; content_max_width=&#8221;1400px&#8221; admin_label=&#8221;Chapter&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_line_height=&#8221;1.5em&#8221; body_font=&#8221;Gotham kinda bold||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.9em&#8221; background_color=&#8221;#ffffff&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;30px|40px|30px|40px&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_zoom=&#8221;20%&#8221; animation_starting_opacity=&#8221;100%&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;60px&#8221; box_shadow_color=&#8221;rgba(10,3,3,0.06)&#8221; image_max_width=&#8221;64px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>Il n'existe actuellement aucun ensemble de donn\u00e9es fiable \u00e0 l'\u00e9chelle europ\u00e9enne permettant d'attribuer chaque cas d'insuffisance h\u00e9patique \u00e0 une cause sp\u00e9cifique. Cependant, la litt\u00e9rature scientifique identifie syst\u00e9matiquement les principaux groupes \u00e9tiologiques suivants.<\/p>\n<ol>\n<li><strong> L\u00e9sion obst\u00e9tricale du sphincter anal (OASI)<\/strong><\/li>\n<\/ol>\n<p>Les l\u00e9sions obst\u00e9tricales sont g\u00e9n\u00e9ralement consid\u00e9r\u00e9es comme la <strong>cause identifiable la plus fr\u00e9quente d'incontinence f\u00e9cale chez les femmes<\/strong>.<\/p>\n<p>Principales conclusions :<\/p>\n<ul>\n<li>L'OASI survient dans 2,91 TP3T des accouchements par voie vaginale au Royaume-Uni, et chez 61 TP3T des femmes qui accouchent pour la premi\u00e8re fois. <a href=\"https:\/\/www.researchgate.net\/publication\/365355927_The_incidence_of_anal_incontinence_following_obstetric_anal_sphincter_injury_OASI_graded_using_the_Sultan_classification_A_network_meta-analysis\">(Okeahialam et al., 2022)<\/a><\/li>\n<li>Plus de <strong>20% de femmes peuvent souffrir d'incontinence anale dans les cinq ans suivant un accouchement par voie basse<\/strong>, bien que la gravit\u00e9 des sympt\u00f4mes puisse varier. <a href=\"https:\/\/www.researchgate.net\/publication\/365355927_The_incidence_of_anal_incontinence_following_obstetric_anal_sphincter_injury_OASI_graded_using_the_Sultan_classification_A_network_meta-analysis\">(Okeahialam et al., 2022)<\/a><\/li>\n<\/ul>\n<ol start=\"2\">\n<li><strong> Vieillissement et d\u00e9g\u00e9n\u00e9rescence du plancher pelvien<\/strong><\/li>\n<\/ol>\n<p>L'\u00e2ge est l'un des facteurs de risque les plus importants de FI. La m\u00e9ta-analyse de 2024 <a href=\"https:\/\/www.cghjournal.org\/article\/S1542-3565(23)00715-2\/fulltext\">(Mack et al., 2024)<\/a> trouv\u00e9 :<\/p>\n<ul>\n<li>Adultes \u00e2g\u00e9s de 60 ans et plus : <strong>9.31 Pr\u00e9valence du TP3T<\/strong><\/li>\n<li>Adultes \u00e2g\u00e9s de moins de 60 ans : <strong>Pr\u00e9valence du 4.9%<\/strong><\/li>\n<\/ul>\n<p>Parmi les causes li\u00e9es \u00e0 l'\u00e2ge, on peut citer :<\/p>\n<ul>\n<li>Affaiblissement progressif du sphincter<\/li>\n<li>Diminution de la sensibilit\u00e9 rectale<\/li>\n<li>Dysfonctionnement du plancher pelvien<\/li>\n<li>Fragilit\u00e9 et mobilit\u00e9 r\u00e9duite<\/li>\n<\/ul>\n<p>De nombreux experts consid\u00e8rent que les troubles li\u00e9s \u00e0 l'\u00e2ge constituent la <strong>principal facteur contribuant \u00e0 la pr\u00e9valence globale des troubles alimentaires<\/strong>.<\/p>\n<ol start=\"3\">\n<li><strong> Cancer colorectal et traitement du cancer<\/strong><\/li>\n<\/ol>\n<p>Les progr\u00e8s r\u00e9alis\u00e9s dans le traitement du cancer du rectum ont permis d'am\u00e9liorer le taux de survie, mais ont \u00e9galement entra\u00een\u00e9 une augmentation du nombre de patients souffrant de troubles intestinaux.<\/p>\n<p>Chez les patients subissant une intervention chirurgicale pour un cancer du rectum avec pr\u00e9servation du sphincter :<\/p>\n<ul>\n<li>Environ 40% pr\u00e9sentent des sympt\u00f4mes du syndrome de r\u00e9section ant\u00e9rieure basse (LARS). <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7034376\/\">(Keane et al., 2020)<\/a><\/li>\n<li>Les sympt\u00f4mes comprennent souvent une envie pressante, des crises, une miction fr\u00e9quente et une incontinence f\u00e9cale.<\/li>\n<\/ul>\n<p>Il s'agit l\u00e0 de l'un des groupes les plus importants pris en charge dans les services sp\u00e9cialis\u00e9s en chirurgie colorectale et du plancher pelvien.<\/p>\n<ol start=\"4\">\n<li><strong> Maladie neurologique<\/strong><\/li>\n<\/ol>\n<p>Les troubles neurologiques peuvent alt\u00e9rer la sensibilit\u00e9 ano-rectale, le contr\u00f4le des sphincters et la coordination intestinale. (<a href=\"https:\/\/www.nature.com\/articles\/s41572-022-00381-7\">Rao, Bharucha et al., 2022<\/a>)<\/p>\n<p>Parmi les causes principales, on peut citer :<\/p>\n<ul>\n<li>Accident vasculaire c\u00e9r\u00e9bral<\/li>\n<li>Scl\u00e9rose en plaques<\/li>\n<li>La maladie de Parkinson<\/li>\n<li>L\u00e9sion de la moelle \u00e9pini\u00e8re<\/li>\n<li>Neuropathie diab\u00e9tique<\/li>\n<\/ul>\n<p>Les maladies neurologiques rev\u00eatent une importance particuli\u00e8re chez les personnes \u00e2g\u00e9es et les patients en soins de longue dur\u00e9e.<\/p>\n<ol start=\"5\">\n<li><strong> Diarrh\u00e9e chronique et troubles fonctionnels intestinaux<\/strong><\/li>\n<\/ol>\n<p>Des selles molles peuvent mettre \u00e0 rude \u00e9preuve m\u00eame un m\u00e9canisme de continence intact. Parmi les affections couramment associ\u00e9es, on peut citer :<\/p>\n<ul>\n<li>Syndrome du c\u00f4lon irritable (SCI)<\/li>\n<li>Maladie inflammatoire chronique de l'intestin (MICI)<\/li>\n<li>Diarrh\u00e9e due aux acides biliaires<\/li>\n<li>Diarrh\u00e9e d'origine m\u00e9dicamenteuse<\/li>\n<\/ul>\n<p>Ces affections sont souvent \u00e0 l'origine de ces probl\u00e8mes ou constituent un facteur contributif majeur.<\/p>\n<ol start=\"6\">\n<li><strong> Ant\u00e9c\u00e9dents de chirurgie et de traumatismes ano-rectaux<\/strong><\/li>\n<\/ol>\n<p>Une proportion plus faible, mais cliniquement significative, de patients d\u00e9veloppe une FI \u00e0 la suite de :<\/p>\n<ul>\n<li>Chirurgie des h\u00e9morro\u00efdes<\/li>\n<li>Chirurgie des fistules anales<\/li>\n<li>Proc\u00e9dures de dilatation anale<\/li>\n<li>Traumatisme pelvien<\/li>\n<li>Autres interventions ano-rectales<\/li>\n<\/ul>[\/et_pb_blurb][et_pb_blurb title=&#8221;References&#8221; url=&#8221;#&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;64px&#8221; content_max_width=&#8221;1400px&#8221; admin_label=&#8221;Chapter&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_line_height=&#8221;1.5em&#8221; body_font=&#8221;Gotham kinda bold||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.9em&#8221; background_color=&#8221;#ffffff&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;30px|40px|30px|40px&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_zoom=&#8221;20%&#8221; animation_starting_opacity=&#8221;100%&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;60px&#8221; box_shadow_color=&#8221;rgba(10,3,3,0.06)&#8221; image_max_width=&#8221;64px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>Mack et al. (2024). <em>Pr\u00e9valence mondiale de l'incontinence f\u00e9cale chez les adultes vivant \u00e0 domicile : revue syst\u00e9matique et m\u00e9ta-analyse<\/em>. Neurogastroent\u00e9rologie et motilit\u00e9.<br \/><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10948379\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10948379\/<\/a><strong>\u00a0<\/strong><\/p>\n<p>Dudding TC, Vaizey CJ, Kamm MA. (2008). <em>L\u00e9sions obst\u00e9tricales du sphincter anal : incidence, facteurs de risque et prise en charge<\/em>.<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18216527\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/18216527\/<\/a><\/p>\n<p>Okeahialam NA et al. (2022). <em>Incidence de l'incontinence anale cons\u00e9cutive \u00e0 une l\u00e9sion obst\u00e9tricale du sphincter anal<\/em>.<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36379266\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36379266\/<\/a><\/p>\n<p>Rao SSC, Bharucha AE et al. (2022). <em>Incontinence f\u00e9cale<\/em>. Nature Reviews Disease Primers.<br \/><a href=\"https:\/\/www.nature.com\/articles\/s41572-022-00381-7\">https:\/\/www.nature.com\/articles\/s41572-022-00381-7<\/a><\/p>\n<p>Keane C et al. (2020). <em>D\u00e9finition consensuelle internationale du syndrome de r\u00e9section ant\u00e9rieure basse<\/em>.<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32027242\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32027242\/<\/a><\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u201d1\u201d _builder_version=\u201d4.16\u201d _module_preset=\u201ddefault\u201d global_colors_info=\"{}\"][\/et_pb_section]","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module dsm_block_reveal_text dsm_block_reveal_text_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm_block_reveal_text_wrapper\" data-dsm-block-reveal-animation=\"lr\" data-dsm-block-reveal-color=\"#0e94f9\" data-dsm-block-reveal-delay=\"0\" data-dsm-block-reveal-viewport=\"80%\"><h1 class=\"dsm_block_reveal_text_header et_pb_module_header\">PR\u00c9VALENCE<\/h1><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_pb_module dsm_block_reveal_text dsm_block_reveal_text_1\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm_block_reveal_text_wrapper\" data-dsm-block-reveal-animation=\"lr\" data-dsm-block-reveal-color=\"#0e94f9\" data-dsm-block-reveal-delay=\"0.1\" data-dsm-block-reveal-viewport=\"80%\"><h2 class=\"dsm_block_reveal_text_header et_pb_module_header\">ET LES PRINCIPALES CAUSES<\/h2><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_pb_module dsm_tilt_image dsm_tilt_image_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm-tilt-image-wrapper\" data-tilt data-tilt-max=\"15\" data-tilt-speed=\"300\" data-tilt-perspective=\"1000\" data-tilt-scale=\"1.1\" data-tilt-mobile-disable=\"on\" data-tilt-glare data-tilt-max-glare=\"0.5\" data-tilt-reverse=\"false\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap\"><img decoding=\"async\" src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science1shadow-4.png\" alt=\"\" title=\"science1shadow\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Faecal incontinence is common but underreported, and can significantly impact quality of life, social functioning, and healthcare utilisation<div class=\"et_pb_module dsm_tilt_image dsm_tilt_image_1\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm-tilt-image-wrapper\" data-tilt data-tilt-max=\"15\" data-tilt-speed=\"300\" data-tilt-perspective=\"1000\" data-tilt-scale=\"1.1\" data-tilt-mobile-disable=\"on\" data-tilt-glare data-tilt-max-glare=\"0.5\" data-tilt-reverse=\"false\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap\"><img decoding=\"async\" src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science2shadow.png\" alt=\"\" title=\"science2shadow\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>It is thought that 6.5% of Europe (9.1% of women and 7.4% of men) live with faecal incontinence &#8211; that&#8217;s 48 million people<div class=\"et_pb_module dsm_tilt_image dsm_tilt_image_2\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm-tilt-image-wrapper\" data-tilt data-tilt-max=\"15\" data-tilt-speed=\"300\" data-tilt-perspective=\"1000\" data-tilt-scale=\"1.1\" data-tilt-mobile-disable=\"on\" data-tilt-glare data-tilt-max-glare=\"0.5\" data-tilt-reverse=\"false\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap\"><img decoding=\"async\" src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science3shadow-2.png\" alt=\"\" title=\"science3shadow\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Faecal incontinence may be caused by obstetric anal sphincter injury, ageing, colorectal cancer, neurological disease, chronic diarrhoea and other bowel disorders, or previous surgeries Faecal incontinence (FI) is a common but underreported condition that significantly impacts quality of life, social functioning, and healthcare utilisation. The strongest recent evidence comes from a 2024 systematic review and meta-analysis of 80 studies involving more than 548,000 adults worldwide (Mack et al, 2024): Overall prevalence of FI in community-dwelling adults: 8.0% Women: 9.1% Men: 7.4% Sensitivity analyses revealed that the prevalence of FI in Europe is 6.5% [&hellip;]<\/p>","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" custom_padding_last_edited=\"on|phone\" disabled_on=\"off|off|off\" admin_label=\"Hero section\" _builder_version=\"4.16\" background_image=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/AMELIEHEADERBACKGOUND-01-scaled.jpg\" background_position=\"center_left\" custom_margin=\"|||\" custom_padding=\"7%||7%||true|false\" custom_padding_tablet=\"15%||15%||true|false\" custom_padding_phone=\"\" global_colors_info=\"{}\"][et_pb_row use_custom_gutter=\"on\" gutter_width=\"1\" custom_padding_last_edited=\"on|desktop\" _builder_version=\"4.16\" _module_preset=\"default\" width=\"100%\" module_alignment=\"left\" custom_padding=\"|||4%|false|false\" custom_padding_tablet=\"|||6%|false|false\" custom_padding_phone=\"|||7%|false|false\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_block_reveal_text block_reveal_text=\"BENEFITS\" heading_html_tag=\"h1\" block_reveal_color=\"#0e94f9\" block_reveal_delay=\"0\" _builder_version=\"4.16\" _module_preset=\"default\" header_font=\"AMELIE||||||||\" header_text_color=\"#0e94f9\" header_font_size=\"4vw\" custom_padding=\"||||false|false\" custom_padding_tablet=\"||||false|false\" custom_padding_phone=\"||||false|false\" custom_padding_last_edited=\"on|phone\" header_font_size_tablet=\"8vw\" header_font_size_phone=\"10vw\" 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transform_origin_last_edited=\"off|desktop\" transform_styles_last_edited=\"off|desktop\" custom_margin=\"||||false|false\" custom_padding=\"100px|0px|100px|0px\" custom_padding_tablet=\"35px|0px|35px|0px|true|false\" custom_padding_phone=\"15px||15px||true|false\" global_colors_info=\"{}\"][et_pb_row column_structure=\"1_3,1_3,1_3\" _builder_version=\"4.16\" _module_preset=\"default\" animation_style=\"slide\" animation_direction=\"bottom\" animation_intensity_slide=\"11%\" global_colors_info=\"{}\"][et_pb_column type=\"1_3\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_tilt_image src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science1shadow-4.png\" title_text=\"science1shadow\" dsm_tilt_mobile=\"on\" dsm_tilt_scale=\"1.1\" dsm_tilt_max=\"15\" dsm_use_glare=\"on\" dsm_tilt_glare=\"0.5\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/dsm_tilt_image][et_pb_text _builder_version=\"4.16\" text_font=\"Gotham kinda bold||||||||\" text_text_color=\"#000000\" text_font_size=\"16px\" text_line_height=\"1.6em\" header_font=\"Gotham kinda bold|||on|||||\" header_text_color=\"#000000\" header_font_size=\"15px\" header_letter_spacing=\"1px\" header_line_height=\"1.4em\" header_2_font=\"Gotham kinda bold|||on|||||\" header_2_text_color=\"#000000\" header_2_font_size=\"15px\" header_2_letter_spacing=\"1px\" header_2_line_height=\"1.4em\" header_3_font=\"Gotham kinda bold|||on|||||\" header_3_text_color=\"#000000\" header_3_font_size=\"15px\" header_3_letter_spacing=\"1px\" header_3_line_height=\"1.4em\" header_4_font=\"Gotham kinda bold|||on|||||\" header_4_text_color=\"#000000\" header_4_font_size=\"17px\" header_4_letter_spacing=\"1px\" header_4_line_height=\"1.4em\" header_5_font=\"Gotham kinda bold|||on|||||\" header_5_text_color=\"#000000\" header_5_font_size=\"15px\" header_5_letter_spacing=\"1px\" header_5_line_height=\"1.4em\" header_6_font=\"Gotham kinda bold|||on|||||\" header_6_text_color=\"#000000\" header_6_font_size=\"15px\" header_6_letter_spacing=\"1px\" header_6_line_height=\"1.4em\" text_orientation=\"center\" max_width=\"800px\" module_alignment=\"center\" locked=\"off\" global_colors_info=\"{}\"]<p>Potential new regenerative therapies to address unmet clinical needs of large patient groups identified.<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_tilt_image src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science2shadow.png\" title_text=\"science2shadow\" dsm_tilt_mobile=\"on\" dsm_tilt_scale=\"1.1\" dsm_tilt_max=\"15\" dsm_use_glare=\"on\" dsm_tilt_glare=\"0.5\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/dsm_tilt_image][et_pb_text _builder_version=\"4.16\" text_font=\"Gotham kinda bold||||||||\" text_text_color=\"#000000\" text_font_size=\"16px\" text_line_height=\"1.6em\" header_font=\"Gotham kinda bold|||on|||||\" header_text_color=\"#000000\" header_font_size=\"15px\" header_letter_spacing=\"1px\" header_line_height=\"1.4em\" header_2_font=\"Gotham kinda bold|||on|||||\" header_2_text_color=\"#000000\" header_2_font_size=\"15px\" header_2_letter_spacing=\"1px\" header_2_line_height=\"1.4em\" header_3_font=\"Gotham kinda bold|||on|||||\" header_3_text_color=\"#000000\" header_3_font_size=\"15px\" header_3_letter_spacing=\"1px\" header_3_line_height=\"1.4em\" header_4_font=\"Gotham kinda bold|||on|||||\" header_4_text_color=\"#000000\" header_4_font_size=\"17px\" header_4_letter_spacing=\"1px\" header_4_line_height=\"1.4em\" header_5_font=\"Gotham kinda bold|||on|||||\" header_5_text_color=\"#000000\" header_5_font_size=\"15px\" header_5_letter_spacing=\"1px\" header_5_line_height=\"1.4em\" header_6_font=\"Gotham kinda bold|||on|||||\" header_6_text_color=\"#000000\" header_6_font_size=\"15px\" header_6_letter_spacing=\"1px\" header_6_line_height=\"1.4em\" text_orientation=\"center\" max_width=\"800px\" module_alignment=\"center\" locked=\"off\" global_colors_info=\"{}\"]<p>Europe\u2019s position in translational regenerative medicine strengthened.<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_tilt_image src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science3shadow-2.png\" title_text=\"science3shadow\" dsm_tilt_mobile=\"on\" dsm_tilt_scale=\"1.1\" dsm_tilt_max=\"15\" dsm_use_glare=\"on\" dsm_tilt_glare=\"0.5\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/dsm_tilt_image][et_pb_text _builder_version=\"4.16\" text_font=\"Gotham kinda bold||||||||\" text_text_color=\"#000000\" text_font_size=\"16px\" text_line_height=\"1.6em\" header_font=\"Gotham kinda bold|||on|||||\" header_text_color=\"#000000\" header_font_size=\"15px\" header_letter_spacing=\"1px\" header_line_height=\"1.4em\" header_2_font=\"Gotham kinda bold|||on|||||\" header_2_text_color=\"#000000\" header_2_font_size=\"15px\" header_2_letter_spacing=\"1px\" header_2_line_height=\"1.4em\" header_3_font=\"Gotham kinda bold|||on|||||\" header_3_text_color=\"#000000\" header_3_font_size=\"15px\" header_3_letter_spacing=\"1px\" header_3_line_height=\"1.4em\" header_4_font=\"Gotham kinda bold|||on|||||\" header_4_text_color=\"#000000\" header_4_font_size=\"17px\" header_4_letter_spacing=\"1px\" header_4_line_height=\"1.4em\" header_5_font=\"Gotham kinda bold|||on|||||\" header_5_text_color=\"#000000\" header_5_font_size=\"15px\" header_5_letter_spacing=\"1px\" header_5_line_height=\"1.4em\" header_6_font=\"Gotham kinda bold|||on|||||\" header_6_text_color=\"#000000\" header_6_font_size=\"15px\" header_6_letter_spacing=\"1px\" header_6_line_height=\"1.4em\" text_orientation=\"center\" max_width=\"800px\" module_alignment=\"center\" locked=\"off\" global_colors_info=\"{}\"]<p>New therapies for major human diseases and conditions, and new approaches for therapy taken further in the development pipeline.<\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.16\" background_color=\"rgba(0,0,0,0.03)\" background_position=\"top_center\" custom_margin=\"|||\" custom_padding=\"100px||100px|\" global_colors_info=\"{}\"][et_pb_row use_custom_gutter=\"on\" gutter_width=\"4\" _builder_version=\"4.16\" custom_margin=\"||||false|false\" custom_padding=\"0px|||\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" parallax__hover=\"off\" parallax_method__hover=\"on\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Potential new regenerative therapies to address unmet clinical needs of large patient groups identified\" url=\"#\" icon_placement=\"left\" image_icon_width=\"64px\" content_max_width=\"1400px\" admin_label=\"Chapter\" _builder_version=\"4.16\" header_font=\"Gotham kinda bold||||||||\" header_text_color=\"#000000\" header_line_height=\"1.5em\" body_font=\"Gotham kinda bold||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.9em\" background_color=\"#ffffff\" custom_margin=\"|||\" custom_padding=\"30px|40px|30px|40px\" animation_style=\"zoom\" animation_direction=\"bottom\" animation_intensity_zoom=\"20%\" animation_starting_opacity=\"100%\" box_shadow_style=\"preset2\" box_shadow_horizontal=\"0px\" box_shadow_vertical=\"0px\" box_shadow_blur=\"60px\" box_shadow_color=\"rgba(10,3,3,0.06)\" image_max_width=\"64px\" locked=\"off\" global_colors_info=\"{}\"]<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">Faecal incontinence is a common condition affecting approximately 9% of adults in Europe. However, this figure is likely underestimated, as around 70% of individuals do not seek medical advice. Of those who do consult a healthcare professional, only a proportion pursue further treatment, and approximately half are not suitable for currently available options.<\/div>\n<div class=\"x_elementToProof\">The AMELIE approach offers several advantages over existing surgical interventions, which can carry risks such as infection, pain, and device failure or dislocation, sometimes resulting in the need for a permanent stoma. Improved continence outcomes have the potential to benefit not only patients, but also carers and individuals on nursing home waiting lists.<\/div>\n<div class=\"x_elementToProof\">If effective, treatment using implantable cell\u2013microcarrier technology could significantly improve quality of life for citizens across Europe. Presenting this therapy as a realistic option for restoring continence, rather than solely managing symptoms, may also encourage more patients to seek medical advice, thereby increasing access to treatment.<\/div>[\/et_pb_blurb][et_pb_blurb title=\"Europe\u2019s position in translational regenerative medicine strengthened \" url=\"#\" icon_placement=\"left\" image_icon_width=\"64px\" content_max_width=\"1400px\" admin_label=\"Chapter\" _builder_version=\"4.16\" header_font=\"Gotham kinda bold||||||||\" header_text_color=\"#000000\" header_line_height=\"1.5em\" body_font=\"Gotham kinda bold||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.9em\" background_color=\"#ffffff\" custom_margin=\"|||\" custom_padding=\"30px|40px|30px|40px\" animation_style=\"zoom\" animation_direction=\"bottom\" animation_intensity_zoom=\"20%\" animation_starting_opacity=\"100%\" box_shadow_style=\"preset2\" box_shadow_horizontal=\"0px\" box_shadow_vertical=\"0px\" box_shadow_blur=\"60px\" box_shadow_color=\"rgba(10,3,3,0.06)\" image_max_width=\"64px\" locked=\"off\" global_colors_info=\"{}\"]<p><span style=\"font-weight: 400;\">Europe is world-leading in cell-based therapies for patients with FI.<\/span> <span style=\"font-weight: 400;\">As well as reinforcing Europe\u2019s dominant role in the field, AMELIE also represents a step-change in the approach being taken to manufacture and deliver cell-based medicine that will enable European citizens to be the first worldwide to benefit from a pioneering new approach to regenerative medicine.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cell therapy is a rapidly growing area of research. Tissue engineered products are set to grow significantly and provide substantial opportunities to strengthen Europe\u2019s position in translational regenerative medicine. Europe is responsible for approximately 26% of global regenerative medicine companies. The development of innovative technology such as implantable TIPS microcarriers will draw investment to Europe. AMELIE then seeks to advance the competitive positions of European companies as providers of innovative enabling technologies for regenerative medicine. This will enhance AMELIE\u2019s exploitative potential.<\/span><\/p>[\/et_pb_blurb][et_pb_blurb title=\"New therapies for major human diseases and conditions, and new approaches for therapy taken further in the development pipeline\" url=\"#\" icon_placement=\"left\" image_icon_width=\"64px\" content_max_width=\"1400px\" admin_label=\"Chapter\" _builder_version=\"4.16\" header_font=\"Gotham kinda bold||||||||\" header_text_color=\"#000000\" header_line_height=\"1.5em\" body_font=\"Gotham kinda bold||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.9em\" background_color=\"#ffffff\" custom_margin=\"|||\" custom_padding=\"30px|40px|30px|40px\" animation_style=\"zoom\" animation_direction=\"bottom\" animation_intensity_zoom=\"20%\" animation_starting_opacity=\"100%\" box_shadow_style=\"preset2\" box_shadow_horizontal=\"0px\" box_shadow_vertical=\"0px\" box_shadow_blur=\"60px\" box_shadow_color=\"rgba(10,3,3,0.06)\" image_max_width=\"64px\" locked=\"off\" global_colors_info=\"{}\"]<p><span style=\"font-weight: 400;\">AMELIE paves the way for identical or similar innovative treatments using ASMDC cell-microcarrier combinations for a variety of other clinical conditions associated with loss of skeletal muscle function, such as urinary incontinence, muscular dystrophies and volumetric muscle loss associated with trauma injury.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The same scientific rationale and new approach developed in AMELIE is equally applicable to other anchorage-dependent cell types investigated as new regenerative medicine treatments. New products comprised of these anchorage-dependent cells are intended to treat some of the most debilitating diseases that affect muscle, bone, cartilage, ocular, heart\/cardiovascular, gastrointestinal\/liver, kidney, immune and respiratory tissues. Adoption of the implantable TIPS microcarrier technology could have a significant impact on their outcome.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Meanwhile the scale-up manufacturing process for TIPS microparticles developed can be applied to other uses of the microparticle technology currently being investigated in the development pipeline. <\/span><\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_section]","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-31818","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/pages\/31818","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/comments?post=31818"}],"version-history":[{"count":8,"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/pages\/31818\/revisions"}],"predecessor-version":[{"id":31830,"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/pages\/31818\/revisions\/31830"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/fr\/wp-json\/wp\/v2\/media?parent=31818"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}