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AMELIE (A<\/strong><\/span>nchored M<\/span><\/strong>uscle cel<\/strong><\/span>ls for I<\/strong><\/span>ncontinence<\/span><\/strong>) is an innovative collaborative research project funded by the European Union\u2019s Horizon 2020 Framework Programme.<\/p>\n AMELIE is developing a regenerative therapy using a patient\u2019s own muscle cells to repair damaged or weakened sphincter muscle.<\/p>\n<\/div>\n [\/et_pb_cta][et_pb_button button_url=”#Learn-More” button_text=”LEARN MORE” _builder_version=”4.21.0″ _module_preset=”default” custom_button=”on” button_text_size=”12px” button_text_color=”#ffffff” button_bg_color=”#0076C3″ button_border_width=”0px” button_border_color=”#0c71c3″ button_border_radius=”5px” button_letter_spacing=”2px” button_font=”Gotham kinda bold|600||on|||||” button_icon_color=”rgba(255,255,255,0)” button_on_hover=”off” background_layout=”dark” custom_margin=”0px||0px||false|false” custom_padding=”12px|20px|12px|20px|false|false” 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AMELIE is primarily concerned with the effect of injury to the anal sphincter by childbirth, surgery or trauma. Many such patients are unsuitable for current surgical options. 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There will be opportunities to help shape the research, take part in focus groups and surveys, read materials and assist in patient recruitment to clinical trials.<\/span><\/p>\n [\/et_pb_text][et_pb_button button_url=”\/contact” button_text=”LEARN MORE” button_alignment_tablet=”center” button_alignment_phone=”” button_alignment_last_edited=”on|tablet” _builder_version=”4.27.4″ _module_preset=”b3719a75-4a2e-4427-9fcf-d8c04c1f3982″ button_text_size=”14px” button_font=”Gotham kinda bold|600||on|||||” button_icon=”$||divi||400″ button_on_hover=”on” button_letter_spacing_hover=”1px” locked=”off” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” custom_css_main_element=”margin: auto;” global_colors_info=”{}” custom_padding__hover=”|||” custom_css_main_element_last_edited=”on|phone” custom_css_main_element_tablet=”order: 1;” custom_css_main_element_phone=”order: 1;”][et_pb_video src=”https:\/\/www.youtube.com\/watch?v=figrg3PRdO4″ play_icon_color=”#000000″ use_icon_font_size=”on” thumbnail_overlay_color=”rgba(0,0,0,0.6)” _builder_version=”4.21.0″ _module_preset=”default” width=”58vh” width_tablet=”100%” width_phone=”” width_last_edited=”on|desktop” module_alignment=”right” custom_margin=”||||false|false” custom_padding=”||||false|false” module_alignment_tablet=”center” module_alignment_phone=”center” module_alignment_last_edited=”on|phone” global_colors_info=”{}” play_icon_color__hover_enabled=”on|hover” play_icon_color__hover=”#000000″][\/et_pb_video][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/amelie-project.eu\/wp-content\/uploads\/2026\/07\/AMELIE-Timeline-updated-220726.png” title_text=”AMELIE Timeline updated 220726″ align=”center” _builder_version=”4.27.4″ _module_preset=”default” border_radii=”on|15px|15px|15px|15px” border_width_top=”18px” border_color_top=”#0C71C3″ box_shadow_style=”preset1″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Testimonial” _builder_version=”4.16″ custom_padding=”28px||101px|||” disabled=”on” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”1440px” custom_margin=”3.8%|auto||auto|false|false” custom_padding=”|40px||40px” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”6%” animation_starting_opacity=”100%” border_radii=”on|15px|15px|15px|15px” border_color_all=”#0076C3″ border_width_top=”18px” border_color_top=”#0076c3″ box_shadow_style=”preset3″ box_shadow_vertical=”39px” box_shadow_blur=”80px” box_shadow_color=”rgba(0,0,0,0.1)” use_custom_width=”on” custom_width_px=”1440px” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_testimonial author=”Diana Davis” job_title=”Happy Buyer” portrait_url=”https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/portrait-square-07.jpg” quote_icon=”off” _builder_version=”4.16″ body_font=”Lato||on||||||” body_text_color=”#898f99″ body_font_size=”20px” body_line_height=”2em” use_background_color=”off” custom_margin=”||60px|” box_shadow_style_image=”preset3″ box_shadow_color_image=”rgba(0,0,0,0.14)” global_colors_info=”{}”]”Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. 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animation=”off” link_option_url=”\/our-research#faecal-incontinence-about-the-condition” border_radii=”on|15px|15px|15px|15px” border_radii_image=”on|100%|100%|100%|100%” box_shadow_style=”preset2″ box_shadow_horizontal=”0px” box_shadow_blur=”54px” box_shadow_spread=”-2px” box_shadow_color=”rgba(0,0,0,0.04)” icon_font_size=”40px” use_circle=”on” circle_color=”#0076c3″ global_colors_info=”{}” box_shadow_spread__hover=”13px” box_shadow_spread__hover_enabled=”on|desktop” image_icon_background_color__sticky_enabled=”#424242″ image_icon_background_color__sticky=”#424242″]<\/p>\n Faecal Incontinence: <\/span>About The Condition<\/span><\/p>\n [\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb use_icon=”on” font_icon=”||divi||400″ icon_color=”#ffffff” image_icon_background_color=”#0076c3″ image_icon_width=”40px” _builder_version=”4.16″ header_font=”Gotham kinda bold|||on|||||” header_text_color=”#000000″ header_font_size=”15px” header_letter_spacing=”1px” header_line_height=”1.4em” body_font=”Gotham kinda bold|100|||||||” body_text_color=”#000000″ body_line_height=”1.6em” image_icon_custom_padding=”25px|25px|25px|25px|false|false” text_orientation=”center” height=”280px” height_tablet=”” height_phone=”” height_last_edited=”on|desktop” custom_margin=”|||” custom_padding=”60px|40px|60px|40px” animation=”off” link_option_url=”\/our-research#faecal-incontinence-and-regenerative-medicine” border_radii=”on|15px|15px|15px|15px” border_radii_image=”on|100%|100%|100%|100%” box_shadow_style=”preset2″ box_shadow_horizontal=”0px” box_shadow_blur=”54px” box_shadow_spread=”-2px” box_shadow_color=”rgba(0,0,0,0.04)” icon_font_size=”40px” use_circle=”on” circle_color=”#0076c3″ global_colors_info=”{}” box_shadow_spread__hover_enabled=”on|desktop” box_shadow_spread__hover=”13px” image_icon_background_color__sticky_enabled=”#424242″ image_icon_background_color__sticky=”#424242″]<\/p>\n Faecal Incontinence and Regenerative Medicine<\/span><\/p>\n [\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb use_icon=”on” font_icon=”||divi||400″ icon_color=”#ffffff” image_icon_background_color=”#0076c3″ image_icon_width=”40px” _builder_version=”4.16″ header_font=”Gotham kinda bold|||on|||||” header_text_color=”#000000″ header_font_size=”15px” header_letter_spacing=”1px” header_line_height=”1.4em” body_font=”Gotham kinda bold|100|||||||” body_text_color=”#000000″ body_line_height=”1.6em” image_icon_custom_padding=”25px|25px|25px|25px|false|false” text_orientation=”center” height=”280px” height_tablet=”” height_phone=”” height_last_edited=”on|tablet” custom_margin=”|||” custom_padding=”60px|40px|60px|40px” animation=”off” link_option_url=”\/our-research#why-are-conventional-methods-not-working” 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These cells are attached to biodegradable microcarriers, which:<\/div>\n\n
\n\nAMELIE brings together 13 partner organisations from nine countries, combining expertise from academia, healthcare, industry, and research to develop new treatments for people living with faecal incontinence.<\/div>\n<\/div>\nThe project is coordinated by University College London (UCL) and led by Professor Richard Day, Professor of Regenerative Medicine Technology at UCL<\/div>\nCan cell therapy restore muscle function?<\/h3>\n
Our Partners<\/h3>\n
Our Research<\/h3>\n
The AMELIE project brings together a highly interdisciplinary consortium of experts to develop a novel regenerative intervention using autologous skeletal muscle-derived cells to restore sphincter muscle function. In this approach, autologous skeletal muscle-derived cells are attached to implantable microcarriers to enhance cell delivery and engraftment in patients with faecal incontinence.<\/div>\nThe therapy will be evaluated in a randomised clinical trial. It is anticipated that this strategy will improve cell viability, increase the likelihood of muscle regeneration, and ultimately contribute to improved continence outcomes.<\/div>\nGet Involved<\/h3>\n
\n[\/et_pb_testimonial][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_testimonial author=”Jessica Bowen” job_title=”Happy Renter” portrait_url=”https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/portrait-square-08.jpg” quote_icon=”off” _builder_version=”4.16″ body_font=”Lato||on||||||” body_text_color=”#898f99″ body_font_size=”20px” body_line_height=”2em” use_background_color=”off” custom_margin=”||60px|” box_shadow_style_image=”preset3″ box_shadow_color_image=”rgba(0,0,0,0.14)” locked=”off” global_colors_info=”{}”]”Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat.
\n[\/et_pb_testimonial][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Features” _builder_version=”4.16″ custom_padding=”80px|0px|80px|0px|false|false” disabled=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_margin=”|||” custom_padding=”0px||0px|||” border_color_all=”#0076C3″ border_color_top=”#0076c3″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Gotham kinda bold||||||||” text_font_size=”16px” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”Gotham kinda bold||||||||” header_2_text_color=”#000000″ header_2_font_size=”32px” header_2_line_height=”1.5em” header_3_font=”Gotham kinda bold||||||||” text_orientation=”center” max_width=”800px” module_alignment=”center” locked=”off” global_colors_info=”{}”]<\/p>\nThe Science Behind AMELIE<\/h2>\n
Ready to get started?<\/h2>\n
Ready to learn more?<\/h2>\n
Ready to get started?<\/h2>\n
\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\tAMELIE<\/h1><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>AMELIE (Anchored Muscle cells for Incontinence) est un projet de recherche collaboratif innovant financ\u00e9 par le programme-cadre \u00ab Horizon 2020 \u00bb de l\u2019Union europ\u00e9enne. AMELIE d\u00e9veloppe une th\u00e9rapie r\u00e9g\u00e9n\u00e9rative utilisant les propres cellules musculaires du patient pour r\u00e9parer le muscle sphincter endommag\u00e9 ou affaibli.
\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t![\"\"](\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2026\/07\/amelie-cells.jpg\" "\\"amelie-cells\\"")
<\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Notre mission : proposer une th\u00e9rapie cellulaire durable et Ces cellules sont fix\u00e9es \u00e0 des microporteurs biod\u00e9gradables qui : favorisent la survie cellulaire encouragent la r\u00e9g\u00e9n\u00e9ration tissulaire am\u00e9liorent l\u2019administration du traitement dans la zone touch\u00e9e. En exploitant la capacit\u00e9 naturelle du corps \u00e0 se r\u00e9parer, AMELIE vise \u00e0 proposer un traitement durable et peu invasif contre l\u2019incontinence f\u00e9cale. Cette technologie pr\u00e9sente \u00e9galement des applications potentielles pour d\u2019autres l\u00e9sions musculaires et pathologies au-del\u00e0 de la sant\u00e9 intestinale. AMELIE rassemble 13 organisations partenaires issues de neuf pays, combinant l\u2019expertise du monde universitaire, des soins de sant\u00e9, de l\u2019industrie et de la recherche afin de d\u00e9velopper de nouveaux traitements pour les personnes souffrant d\u2019incontinence f\u00e9cale. Le projet est coordonn\u00e9 par l\u2019University College London (UCL) et dirig\u00e9 par le professeur Richard Day, titulaire de la chaire de technologie de m\u00e9decine r\u00e9g\u00e9n\u00e9rative \u00e0 l\u2019UCL.\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t![\"\"](\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2026\/02\/05-VC-Cafe-London-260226-Copy-1080x675.jpg\")
\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tRepr\u00e9sentation du projet AMELIE lors du Sommet sur l'innovation chirurgicale 2026 de la Cleveland Clinic<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t\t\t<\/header>\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t