{"id":29994,"date":"2023-09-10T09:09:36","date_gmt":"2023-09-10T09:09:36","guid":{"rendered":"https:\/\/amelie-project.eu\/?post_type=category-publication&p=29994"},"modified":"2024-02-26T16:22:58","modified_gmt":"2024-02-26T16:22:58","slug":"publicacion-3","status":"publish","type":"publication","link":"https:\/\/amelie-project.eu\/es\/publicacion\/publicacion-3\/","title":{"rendered":"Consideraciones sobre bioprocesamiento para la fabricaci\u00f3n de c\u00e9lulas terap\u00e9uticas de m\u00fasculo esquel\u00e9tico y liso"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.21.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.21.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral y Cl\u00e1udia L da Silva.<\/strong><\/p>\n

Bioingenier\u00eda. 2023;10(9):1067.<\/p>\n

Los enfoques de ingenier\u00eda de tejidos en el contexto muscular representan un campo emergente prometedor para abordar los retos terap\u00e9uticos actuales relacionados con m\u00faltiples condiciones patol\u00f3gicas que afectan a los compartimentos musculares, ya sea m\u00fasculo esquel\u00e9tico o m\u00fasculo liso, responsables de la contracci\u00f3n involuntaria y voluntaria, respectivamente. En esta revisi\u00f3n, se abordan varias caracter\u00edsticas y par\u00e1metros implicados en el bioprocesado de c\u00e9lulas musculares. Se describe el proceso de aislamiento celular, en funci\u00f3n del tipo de tejido (m\u00fasculo liso o esquel\u00e9tico), seguido de la descripci\u00f3n de los retos que plantea el uso de tejido de donantes adultos y las estrategias para superar los obst\u00e1culos que impiden alcanzar un n\u00famero de c\u00e9lulas relevante para una aplicaci\u00f3n cl\u00ednica. En concreto, se destaca el uso de c\u00e9lulas madre\/progenitoras como fuente de c\u00e9lulas musculares lisas y esquel\u00e9ticas para el desarrollo de un producto celular capaz de mantener la identidad y funcionalidad de la c\u00e9lula diana. Por otra parte, teniendo en cuenta la necesidad de un bioproceso robusto y rentable para la fabricaci\u00f3n de c\u00e9lulas, tambi\u00e9n se aborda la combinaci\u00f3n de c\u00e9lulas musculares con biomateriales y la necesidad de escalado previendo aplicaciones cl\u00ednicas.<\/p>\n

<\/p>\n

Acceda al documento completo aqu\u00ed:<\/p>\n

<\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/a><\/p>\n

<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral and Cl\u00e1udia L da Silva. Bioengineering. 2023;10(9):1067. Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle or smooth muscle, responsible for involuntary and voluntary contraction, respectively. In this review, several features and parameters involved in the bioprocessing of muscle cells are addressed. The cell isolation process is depicted, depending on the type of tissue (smooth or skeletal muscle), followed by the description of the challenges involving the use of adult donor tissue and the strategies to overcome the hurdles of reaching relevant cell numbers towards a clinical application. Specifically, the use of stem\/progenitor cells is highlighted as a source for smooth and skeletal muscle cells towards the development of a cellular product able to maintain the target cell\u2019s identity and functionality. Moreover, taking into account the need for a robust and cost-effective bioprocess for cell manufacturing, the combination of muscle cells with biomaterials and the need for scale-up envisioning clinical applications are also approached. Access the full paper here: https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/p>","protected":false},"featured_media":31459,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\n

Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral and Cl\u00e1udia L da Silva.
Bioengineering. 2023;10(9):1067.<\/strong><\/p>\n\n\n\n

Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle or smooth muscle, responsible for involuntary and voluntary contraction, respectively. In this review, several features and parameters involved in the bioprocessing of muscle cells are addressed. The cell isolation process is depicted, depending on the type of tissue (smooth or skeletal muscle), followed by the description of the challenges involving the use of adult donor tissue and the strategies to overcome the hurdles of reaching relevant cell numbers towards a clinical application. Specifically, the use of stem\/progenitor cells is highlighted as a source for smooth and skeletal muscle cells towards the development of a cellular product able to maintain the target cell\u2019s identity and functionality. Moreover, taking into account the need for a robust and cost-effective bioprocess for cell manufacturing, the combination of muscle cells with biomaterials and the need for scale-up envisioning clinical applications are also approached.<\/p>\n\n\n\n

Access the full paper here:\u00a0<\/p>\n\n\n\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/a><\/p>\n","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_links_to":"","_links_to_target":""},"categories":[43],"class_list":["post-29994","publication","type-publication","status-publish","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/publication\/29994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/types\/publication"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/media\/31459"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/media?parent=29994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/categories?post=29994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}