{"id":31818,"date":"2026-07-02T09:56:49","date_gmt":"2026-07-02T09:56:49","guid":{"rendered":"https:\/\/amelie-project.eu\/?page_id=31818"},"modified":"2026-07-02T09:56:52","modified_gmt":"2026-07-02T09:56:52","slug":"incontinencia-fecal-en-europa-prevalencia-y-causas-principales","status":"publish","type":"page","link":"https:\/\/amelie-project.eu\/es\/incontinencia-fecal-en-europa-prevalencia-y-causas-principales\/","title":{"rendered":"Incontinencia fecal en Europa: prevalencia y causas principales"},"content":{"rendered":"[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Hero section&#8221; _builder_version=&#8221;4.16&#8243; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/AMELIEHEADERBACKGOUND-01-scaled.jpg&#8221; background_position=&#8221;center_left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;7%||7%||true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; module_alignment=&#8221;left&#8221; custom_padding=&#8221;|||4%|false|false&#8221; custom_padding_tablet=&#8221;|||6%|false|false&#8221; custom_padding_phone=&#8221;|||7%|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_block_reveal_text block_reveal_text=&#8221;PREVALENCE&#8221; heading_html_tag=&#8221;h1&#8243; block_reveal_color=&#8221;#0e94f9&#8243; block_reveal_delay=&#8221;0&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;AMELIE||||||||&#8221; header_text_color=&#8221;#0e94f9&#8243; header_font_size=&#8221;4vw&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_tablet=&#8221;||||false|false&#8221; custom_padding_phone=&#8221;||||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; hover_enabled=&#8221;0&#8243; header_font_size_tablet=&#8221;8vw&#8221; header_font_size_phone=&#8221;10vw&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/dsm_block_reveal_text][dsm_block_reveal_text block_reveal_text=&#8221;AND MAJOR CAUSES&#8221; block_reveal_color=&#8221;#0e94f9&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;AMELIE||||||||&#8221; header_text_color=&#8221;#0e94f9&#8243; header_font_size=&#8221;3vw&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_tablet=&#8221;||||false|false&#8221; custom_padding_phone=&#8221;||||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; hover_enabled=&#8221;0&#8243; header_font_size_tablet=&#8221;6vw&#8221; header_font_size_phone=&#8221;7vw&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/dsm_block_reveal_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.16&#8243; transform_scale_tablet=&#8221;90%|90%&#8221; transform_scale_last_edited=&#8221;off|desktop&#8221; transform_translate_last_edited=&#8221;off|desktop&#8221; transform_rotate_last_edited=&#8221;off|desktop&#8221; transform_skew_last_edited=&#8221;off|desktop&#8221; transform_origin_last_edited=&#8221;off|desktop&#8221; transform_styles_last_edited=&#8221;off|desktop&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;100px|0px|100px|0px&#8221; custom_padding_tablet=&#8221;35px|0px|35px|0px|true|false&#8221; custom_padding_phone=&#8221;15px||15px||true|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_slide=&#8221;11%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_tilt_image src=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science1shadow-4.png&#8221; title_text=&#8221;science1shadow&#8221; dsm_tilt_mobile=&#8221;on&#8221; dsm_tilt_scale=&#8221;1.1&#8243; dsm_tilt_max=&#8221;15&#8243; dsm_use_glare=&#8221;on&#8221; dsm_tilt_glare=&#8221;0.5&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_tilt_image][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;15px&#8221; header_letter_spacing=&#8221;1px&#8221; header_line_height=&#8221;1.4em&#8221; header_2_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;15px&#8221; header_2_letter_spacing=&#8221;1px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;15px&#8221; header_3_letter_spacing=&#8221;1px&#8221; header_3_line_height=&#8221;1.4em&#8221; header_4_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_4_text_color=&#8221;#000000&#8243; header_4_font_size=&#8221;17px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.4em&#8221; header_5_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_5_text_color=&#8221;#000000&#8243; header_5_font_size=&#8221;15px&#8221; header_5_letter_spacing=&#8221;1px&#8221; header_5_line_height=&#8221;1.4em&#8221; header_6_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_6_text_color=&#8221;#000000&#8243; header_6_font_size=&#8221;15px&#8221; header_6_letter_spacing=&#8221;1px&#8221; header_6_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;800px&#8221; module_alignment=&#8221;center&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>La incontinencia fecal es frecuente, pero no se notifica en todos los casos, y puede <strong>afectar de manera significativa a la calidad de vida<\/strong>, el funcionamiento social y el uso de los servicios sanitarios<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_tilt_image src=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science2shadow.png&#8221; title_text=&#8221;science2shadow&#8221; dsm_tilt_mobile=&#8221;on&#8221; dsm_tilt_scale=&#8221;1.1&#8243; dsm_tilt_max=&#8221;15&#8243; dsm_use_glare=&#8221;on&#8221; dsm_tilt_glare=&#8221;0.5&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_tilt_image][et_pb_text _builder_version=&#8221;4.27.4&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;15px&#8221; header_letter_spacing=&#8221;1px&#8221; header_line_height=&#8221;1.4em&#8221; header_2_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;15px&#8221; header_2_letter_spacing=&#8221;1px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;15px&#8221; header_3_letter_spacing=&#8221;1px&#8221; header_3_line_height=&#8221;1.4em&#8221; header_4_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_4_text_color=&#8221;#000000&#8243; header_4_font_size=&#8221;17px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.4em&#8221; header_5_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_5_text_color=&#8221;#000000&#8243; header_5_font_size=&#8221;15px&#8221; header_5_letter_spacing=&#8221;1px&#8221; header_5_line_height=&#8221;1.4em&#8221; header_6_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_6_text_color=&#8221;#000000&#8243; header_6_font_size=&#8221;15px&#8221; header_6_letter_spacing=&#8221;1px&#8221; header_6_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;800px&#8221; module_alignment=&#8221;center&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<p>Se estima que 6,51 TP3T de la poblaci\u00f3n europea (9,11 TP3T de mujeres y 7,41 TP3T de hombres) padecen incontinencia fecal; eso supone <strong>48 millones de personas<\/strong><\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_tilt_image src=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science3shadow-2.png&#8221; title_text=&#8221;science3shadow&#8221; dsm_tilt_mobile=&#8221;on&#8221; dsm_tilt_scale=&#8221;1.1&#8243; dsm_tilt_max=&#8221;15&#8243; dsm_use_glare=&#8221;on&#8221; dsm_tilt_glare=&#8221;0.5&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_tilt_image][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;15px&#8221; header_letter_spacing=&#8221;1px&#8221; header_line_height=&#8221;1.4em&#8221; header_2_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;15px&#8221; header_2_letter_spacing=&#8221;1px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;15px&#8221; header_3_letter_spacing=&#8221;1px&#8221; header_3_line_height=&#8221;1.4em&#8221; header_4_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_4_text_color=&#8221;#000000&#8243; header_4_font_size=&#8221;17px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.4em&#8221; header_5_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_5_text_color=&#8221;#000000&#8243; header_5_font_size=&#8221;15px&#8221; header_5_letter_spacing=&#8221;1px&#8221; header_5_line_height=&#8221;1.4em&#8221; header_6_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_6_text_color=&#8221;#000000&#8243; header_6_font_size=&#8221;15px&#8221; header_6_letter_spacing=&#8221;1px&#8221; header_6_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;800px&#8221; module_alignment=&#8221;center&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>La incontinencia fecal puede estar provocada por <strong>lesi\u00f3n obst\u00e9trica del esf\u00ednter anal, envejecimiento, c\u00e1ncer colorrectal, enfermedades neurol\u00f3gicas, diarrea cr\u00f3nica y otros trastornos intestinales, o intervenciones quir\u00fargicas previas<\/strong><\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(0,0,0,0.03)&#8221; background_position=&#8221;top_center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;100px||100px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;4&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;0px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; parallax__hover=&#8221;off&#8221; parallax_method__hover=&#8221;on&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;How many people in Europe are affected?&#8221; url=&#8221;#&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;64px&#8221; content_max_width=&#8221;1400px&#8221; admin_label=&#8221;Chapter&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_line_height=&#8221;1.5em&#8221; body_font=&#8221;Gotham kinda bold||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.9em&#8221; background_color=&#8221;#ffffff&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;30px|40px|30px|40px&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_zoom=&#8221;20%&#8221; animation_starting_opacity=&#8221;100%&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;60px&#8221; box_shadow_color=&#8221;rgba(10,3,3,0.06)&#8221; image_max_width=&#8221;64px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">\n<p>La incontinencia fecal (IF) es una afecci\u00f3n frecuente, aunque poco notificada, que afecta de manera significativa a la calidad de vida, al funcionamiento social y al uso de los servicios sanitarios.<\/p>\n<p>Las pruebas m\u00e1s s\u00f3lidas de los \u00faltimos tiempos proceden de una revisi\u00f3n sistem\u00e1tica y un metaan\u00e1lisis de 2024, en los que se analizaron 80 estudios con m\u00e1s de 548 000 adultos de todo el mundo <a href=\"https:\/\/www.cghjournal.org\/article\/S1542-3565(23)00715-2\/fulltext\">(Mack et al., 2024)<\/a>:<\/p>\n<ul>\n<li>Prevalencia global de la inactividad f\u00edsica en adultos que viven en la comunidad: <strong>8.0%<\/strong><\/li>\n<li>Mujeres: <strong>9.1%<\/strong><\/li>\n<li>Hombres: <strong>7.4%<\/strong><\/li>\n<li>Los an\u00e1lisis de sensibilidad revelaron que la prevalencia de la FI en Europa es de 6,5%<\/li>\n<li>Si aplicamos estas estimaciones de prevalencia a la poblaci\u00f3n europea (unos 743 millones de personas), se deduce que alrededor de 48 millones de personas en Europa padecen FI.<\/li>\n<\/ul>\n<\/div>[\/et_pb_blurb][et_pb_blurb title=&#8221;What causes faecal incontinence?&#8221; url=&#8221;#&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;64px&#8221; content_max_width=&#8221;1400px&#8221; admin_label=&#8221;Chapter&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_line_height=&#8221;1.5em&#8221; body_font=&#8221;Gotham kinda bold||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.9em&#8221; background_color=&#8221;#ffffff&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;30px|40px|30px|40px&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_zoom=&#8221;20%&#8221; animation_starting_opacity=&#8221;100%&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;60px&#8221; box_shadow_color=&#8221;rgba(10,3,3,0.06)&#8221; image_max_width=&#8221;64px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>En la actualidad no existe ning\u00fan conjunto de datos fiable a escala europea que atribuya cada caso de FI a una causa concreta. Sin embargo, la bibliograf\u00eda especializada identifica de forma sistem\u00e1tica los siguientes grupos etiol\u00f3gicos principales.<\/p>\n<ol>\n<li><strong> Lesi\u00f3n obst\u00e9trica del esf\u00ednter anal (OASI)<\/strong><\/li>\n<\/ol>\n<p>La lesi\u00f3n obst\u00e9trica se considera generalmente como la <strong>la causa identificable m\u00e1s frecuente de incontinencia fecal en las mujeres<\/strong>.<\/p>\n<p>Conclusiones principales:<\/p>\n<ul>\n<li>La OASI se produce en el 2,9% de todos los partos vaginales en el Reino Unido y en el 6% de las mujeres que dan a luz por primera vez. <a href=\"https:\/\/www.researchgate.net\/publication\/365355927_The_incidence_of_anal_incontinence_following_obstetric_anal_sphincter_injury_OASI_graded_using_the_Sultan_classification_A_network_meta-analysis\">(Okeahialam et al., 2022)<\/a><\/li>\n<li>M\u00e1s de <strong>20% de mujeres pueden sufrir incontinencia anal en los cinco a\u00f1os siguientes al parto vaginal<\/strong>, aunque la gravedad de los s\u00edntomas var\u00eda. <a href=\"https:\/\/www.researchgate.net\/publication\/365355927_The_incidence_of_anal_incontinence_following_obstetric_anal_sphincter_injury_OASI_graded_using_the_Sultan_classification_A_network_meta-analysis\">(Okeahialam et al., 2022)<\/a><\/li>\n<\/ul>\n<ol start=\"2\">\n<li><strong> Envejecimiento y degeneraci\u00f3n del suelo p\u00e9lvico<\/strong><\/li>\n<\/ol>\n<p>La edad es uno de los factores de riesgo m\u00e1s importantes de la FI. El metaan\u00e1lisis de 2024 <a href=\"https:\/\/www.cghjournal.org\/article\/S1542-3565(23)00715-2\/fulltext\">(Mack et al., 2024)<\/a> encontrado:<\/p>\n<ul>\n<li>Adultos de 60 a\u00f1os o m\u00e1s: <strong>9.31 Prevalencia del TP3T<\/strong><\/li>\n<li>Adultos menores de 60 a\u00f1os: <strong>Prevalencia de 4,91 TP3T<\/strong><\/li>\n<\/ul>\n<p>Entre las causas relacionadas con la edad se incluyen:<\/p>\n<ul>\n<li>Debilidad progresiva del esf\u00ednter<\/li>\n<li>Disminuci\u00f3n de la sensibilidad rectal<\/li>\n<li>Disfunci\u00f3n del suelo p\u00e9lvico<\/li>\n<li>Fragilidad y movilidad reducida<\/li>\n<\/ul>\n<p>Muchos expertos consideran que la disfunci\u00f3n relacionada con la edad es la <strong>el principal factor que contribuye a la prevalencia general de la FI<\/strong>.<\/p>\n<ol start=\"3\">\n<li><strong> C\u00e1ncer colorrectal y tratamiento del c\u00e1ncer<\/strong><\/li>\n<\/ol>\n<p>Los avances en el tratamiento del c\u00e1ncer de recto han aumentado la supervivencia, pero tambi\u00e9n han incrementado el n\u00famero de pacientes que padecen disfunci\u00f3n intestinal.<\/p>\n<p>Entre los pacientes sometidos a cirug\u00eda de c\u00e1ncer de recto con preservaci\u00f3n del esf\u00ednter:<\/p>\n<ul>\n<li>Aproximadamente 40% desarrollan s\u00edntomas del s\u00edndrome de resecci\u00f3n anterior baja (LARS). <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7034376\/\">(Keane et al., 2020)<\/a><\/li>\n<li>Entre los s\u00edntomas m\u00e1s frecuentes se encuentran la urgencia, la aparici\u00f3n en r\u00e1fagas, la frecuencia y la incontinencia fecal.<\/li>\n<\/ul>\n<p>Se trata de uno de los grupos m\u00e1s numerosos atendidos en los servicios especializados en colorrectal y suelo p\u00e9lvico.<\/p>\n<ol start=\"4\">\n<li><strong> Enfermedad neurol\u00f3gica<\/strong><\/li>\n<\/ol>\n<p>Las afecciones neurol\u00f3gicas pueden alterar la sensibilidad anorrectal, el control de los esf\u00ednteres y la coordinaci\u00f3n intestinal. (<a href=\"https:\/\/www.nature.com\/articles\/s41572-022-00381-7\">Rao, Bharucha y otros, 2022<\/a>)<\/p>\n<p>Entre las causas m\u00e1s importantes se encuentran:<\/p>\n<ul>\n<li>Accidente cerebrovascular<\/li>\n<li>Esclerosis m\u00faltiple<\/li>\n<li>Enfermedad de Parkinson<\/li>\n<li>Lesi\u00f3n medular<\/li>\n<li>Neuropat\u00eda diab\u00e9tica<\/li>\n<\/ul>\n<p>Las enfermedades neurol\u00f3gicas revisten especial importancia en las personas mayores y en las personas que reciben cuidados de larga duraci\u00f3n.<\/p>\n<ol start=\"5\">\n<li><strong> Diarrea cr\u00f3nica y trastornos funcionales intestinales<\/strong><\/li>\n<\/ol>\n<p>Las heces blandas pueden sobrepasar incluso la capacidad de un mecanismo de continencia intacto. Entre las afecciones asociadas m\u00e1s comunes se incluyen:<\/p>\n<ul>\n<li>S\u00edndrome del intestino irritable (SII)<\/li>\n<li>Enfermedad inflamatoria intestinal (EII)<\/li>\n<li>Diarrea por \u00e1cidos biliares<\/li>\n<li>Diarrea provocada por medicamentos<\/li>\n<\/ul>\n<p>Estas afecciones suelen estar presentes, ya sea como causa principal o como factor determinante.<\/p>\n<ol start=\"6\">\n<li><strong> Cirug\u00eda y traumatolog\u00eda anorrectal previa<\/strong><\/li>\n<\/ol>\n<p>Una proporci\u00f3n menor, pero cl\u00ednicamente relevante, de pacientes desarrolla FI tras:<\/p>\n<ul>\n<li>Cirug\u00eda de hemorroides<\/li>\n<li>Cirug\u00eda de f\u00edstula anal<\/li>\n<li>Procedimientos de dilataci\u00f3n anal<\/li>\n<li>Traumatismo p\u00e9lvico<\/li>\n<li>Otras intervenciones anorrectales<\/li>\n<\/ul>[\/et_pb_blurb][et_pb_blurb title=&#8221;References&#8221; url=&#8221;#&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;64px&#8221; content_max_width=&#8221;1400px&#8221; admin_label=&#8221;Chapter&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_line_height=&#8221;1.5em&#8221; body_font=&#8221;Gotham kinda bold||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.9em&#8221; background_color=&#8221;#ffffff&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;30px|40px|30px|40px&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_zoom=&#8221;20%&#8221; animation_starting_opacity=&#8221;100%&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;60px&#8221; box_shadow_color=&#8221;rgba(10,3,3,0.06)&#8221; image_max_width=&#8221;64px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>Mack et al. (2024). <em>Prevalencia mundial de la incontinencia fecal en adultos que viven en la comunidad: una revisi\u00f3n sistem\u00e1tica y un metaan\u00e1lisis<\/em>. Neurogastroenterolog\u00eda y motilidad.<br \/><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10948379\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10948379\/<\/a><strong>\u00a0<\/strong><\/p>\n<p>Dudding TC, Vaizey CJ, Kamm MA. (2008). <em>Lesi\u00f3n obst\u00e9trica del esf\u00ednter anal: incidencia, factores de riesgo y tratamiento<\/em>.<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18216527\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/18216527\/<\/a><\/p>\n<p>Okeahialam NA y otros (2022). <em>Incidencia de la incontinencia anal tras una lesi\u00f3n obst\u00e9trica del esf\u00ednter anal<\/em>.<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36379266\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36379266\/<\/a><\/p>\n<p>Rao SSC, Bharucha AE y otros (2022). <em>Incontinencia fecal<\/em>. Nature Reviews Disease Primers.<br \/><a href=\"https:\/\/www.nature.com\/articles\/s41572-022-00381-7\">https:\/\/www.nature.com\/articles\/s41572-022-00381-7<\/a><\/p>\n<p>Keane C y otros (2020). <em>Definici\u00f3n consensuada internacional del s\u00edndrome de resecci\u00f3n anterior baja<\/em>.<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32027242\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32027242\/<\/a><\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_section]","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module dsm_block_reveal_text dsm_block_reveal_text_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm_block_reveal_text_wrapper\" data-dsm-block-reveal-animation=\"lr\" data-dsm-block-reveal-color=\"#0e94f9\" data-dsm-block-reveal-delay=\"0\" data-dsm-block-reveal-viewport=\"80%\"><h1 class=\"dsm_block_reveal_text_header et_pb_module_header\">PREVALENCIA<\/h1><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_pb_module dsm_block_reveal_text dsm_block_reveal_text_1\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm_block_reveal_text_wrapper\" data-dsm-block-reveal-animation=\"lr\" data-dsm-block-reveal-color=\"#0e94f9\" data-dsm-block-reveal-delay=\"0.1\" data-dsm-block-reveal-viewport=\"80%\"><h2 class=\"dsm_block_reveal_text_header et_pb_module_header\">Y LAS PRINCIPALES CAUSAS<\/h2><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_pb_module dsm_tilt_image dsm_tilt_image_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm-tilt-image-wrapper\" data-tilt data-tilt-max=\"15\" data-tilt-speed=\"300\" data-tilt-perspective=\"1000\" data-tilt-scale=\"1.1\" data-tilt-mobile-disable=\"on\" data-tilt-glare data-tilt-max-glare=\"0.5\" data-tilt-reverse=\"false\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap\"><img decoding=\"async\" src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science1shadow-4.png\" alt=\"\" title=\"ciencia1sombra\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Faecal incontinence is common but underreported, and can significantly impact quality of life, social functioning, and healthcare utilisation<div class=\"et_pb_module dsm_tilt_image dsm_tilt_image_1\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm-tilt-image-wrapper\" data-tilt data-tilt-max=\"15\" data-tilt-speed=\"300\" data-tilt-perspective=\"1000\" data-tilt-scale=\"1.1\" data-tilt-mobile-disable=\"on\" data-tilt-glare data-tilt-max-glare=\"0.5\" data-tilt-reverse=\"false\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap\"><img decoding=\"async\" src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science2shadow.png\" alt=\"\" title=\"science2shadow\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>It is thought that 6.5% of Europe (9.1% of women and 7.4% of men) live with faecal incontinence &#8211; that&#8217;s 48 million people<div class=\"et_pb_module dsm_tilt_image dsm_tilt_image_2\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm-tilt-image-wrapper\" data-tilt data-tilt-max=\"15\" data-tilt-speed=\"300\" data-tilt-perspective=\"1000\" data-tilt-scale=\"1.1\" data-tilt-mobile-disable=\"on\" data-tilt-glare data-tilt-max-glare=\"0.5\" data-tilt-reverse=\"false\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap\"><img decoding=\"async\" src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science3shadow-2.png\" alt=\"\" title=\"ciencia3sombra\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Faecal incontinence may be caused by obstetric anal sphincter injury, ageing, colorectal cancer, neurological disease, chronic diarrhoea and other bowel disorders, or previous surgeries Faecal incontinence (FI) is a common but underreported condition that significantly impacts quality of life, social functioning, and healthcare utilisation. The strongest recent evidence comes from a 2024 systematic review and meta-analysis of 80 studies involving more than 548,000 adults worldwide (Mack et al, 2024): Overall prevalence of FI in community-dwelling adults: 8.0% Women: 9.1% Men: 7.4% Sensitivity analyses revealed that the prevalence of FI in Europe is 6.5% [&hellip;]<\/p>","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" custom_padding_last_edited=\"on|phone\" disabled_on=\"off|off|off\" admin_label=\"Hero section\" _builder_version=\"4.16\" background_image=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/AMELIEHEADERBACKGOUND-01-scaled.jpg\" background_position=\"center_left\" custom_margin=\"|||\" custom_padding=\"7%||7%||true|false\" custom_padding_tablet=\"15%||15%||true|false\" custom_padding_phone=\"\" global_colors_info=\"{}\"][et_pb_row use_custom_gutter=\"on\" gutter_width=\"1\" custom_padding_last_edited=\"on|desktop\" _builder_version=\"4.16\" _module_preset=\"default\" width=\"100%\" module_alignment=\"left\" custom_padding=\"|||4%|false|false\" custom_padding_tablet=\"|||6%|false|false\" custom_padding_phone=\"|||7%|false|false\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_block_reveal_text block_reveal_text=\"BENEFITS\" heading_html_tag=\"h1\" block_reveal_color=\"#0e94f9\" block_reveal_delay=\"0\" _builder_version=\"4.16\" _module_preset=\"default\" header_font=\"AMELIE||||||||\" header_text_color=\"#0e94f9\" header_font_size=\"4vw\" custom_padding=\"||||false|false\" custom_padding_tablet=\"||||false|false\" custom_padding_phone=\"||||false|false\" custom_padding_last_edited=\"on|phone\" header_font_size_tablet=\"8vw\" header_font_size_phone=\"10vw\" header_font_size_last_edited=\"on|desktop\" global_colors_info=\"{}\"][\/dsm_block_reveal_text][dsm_block_reveal_text block_reveal_text=\"OF AMELIE\" block_reveal_color=\"#0e94f9\" _builder_version=\"4.16\" _module_preset=\"default\" header_font=\"AMELIE||||||||\" header_text_color=\"#0e94f9\" header_font_size=\"3vw\" custom_padding=\"||||false|false\" custom_padding_tablet=\"||||false|false\" custom_padding_phone=\"||||false|false\" custom_padding_last_edited=\"on|phone\" header_font_size_tablet=\"6vw\" header_font_size_phone=\"7vw\" header_font_size_last_edited=\"on|desktop\" global_colors_info=\"{}\"][\/dsm_block_reveal_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" custom_padding_last_edited=\"on|phone\" _builder_version=\"4.16\" transform_scale_tablet=\"90%|90%\" transform_scale_last_edited=\"off|desktop\" transform_translate_last_edited=\"off|desktop\" transform_rotate_last_edited=\"off|desktop\" transform_skew_last_edited=\"off|desktop\" transform_origin_last_edited=\"off|desktop\" transform_styles_last_edited=\"off|desktop\" custom_margin=\"||||false|false\" custom_padding=\"100px|0px|100px|0px\" custom_padding_tablet=\"35px|0px|35px|0px|true|false\" custom_padding_phone=\"15px||15px||true|false\" global_colors_info=\"{}\"][et_pb_row column_structure=\"1_3,1_3,1_3\" _builder_version=\"4.16\" _module_preset=\"default\" animation_style=\"slide\" animation_direction=\"bottom\" animation_intensity_slide=\"11%\" global_colors_info=\"{}\"][et_pb_column type=\"1_3\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_tilt_image src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science1shadow-4.png\" title_text=\"science1shadow\" dsm_tilt_mobile=\"on\" dsm_tilt_scale=\"1.1\" dsm_tilt_max=\"15\" dsm_use_glare=\"on\" dsm_tilt_glare=\"0.5\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/dsm_tilt_image][et_pb_text _builder_version=\"4.16\" text_font=\"Gotham kinda bold||||||||\" text_text_color=\"#000000\" text_font_size=\"16px\" text_line_height=\"1.6em\" header_font=\"Gotham kinda bold|||on|||||\" header_text_color=\"#000000\" header_font_size=\"15px\" header_letter_spacing=\"1px\" header_line_height=\"1.4em\" header_2_font=\"Gotham kinda bold|||on|||||\" header_2_text_color=\"#000000\" header_2_font_size=\"15px\" header_2_letter_spacing=\"1px\" header_2_line_height=\"1.4em\" header_3_font=\"Gotham kinda bold|||on|||||\" header_3_text_color=\"#000000\" header_3_font_size=\"15px\" header_3_letter_spacing=\"1px\" header_3_line_height=\"1.4em\" header_4_font=\"Gotham kinda bold|||on|||||\" header_4_text_color=\"#000000\" header_4_font_size=\"17px\" header_4_letter_spacing=\"1px\" header_4_line_height=\"1.4em\" header_5_font=\"Gotham kinda bold|||on|||||\" header_5_text_color=\"#000000\" header_5_font_size=\"15px\" header_5_letter_spacing=\"1px\" header_5_line_height=\"1.4em\" header_6_font=\"Gotham kinda bold|||on|||||\" header_6_text_color=\"#000000\" header_6_font_size=\"15px\" header_6_letter_spacing=\"1px\" header_6_line_height=\"1.4em\" text_orientation=\"center\" max_width=\"800px\" module_alignment=\"center\" locked=\"off\" global_colors_info=\"{}\"]<p>Potential new regenerative therapies to address unmet clinical needs of large patient groups identified.<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_tilt_image src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science2shadow.png\" title_text=\"science2shadow\" dsm_tilt_mobile=\"on\" dsm_tilt_scale=\"1.1\" dsm_tilt_max=\"15\" dsm_use_glare=\"on\" dsm_tilt_glare=\"0.5\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/dsm_tilt_image][et_pb_text _builder_version=\"4.16\" text_font=\"Gotham kinda bold||||||||\" text_text_color=\"#000000\" text_font_size=\"16px\" text_line_height=\"1.6em\" header_font=\"Gotham kinda bold|||on|||||\" header_text_color=\"#000000\" header_font_size=\"15px\" header_letter_spacing=\"1px\" header_line_height=\"1.4em\" header_2_font=\"Gotham kinda bold|||on|||||\" header_2_text_color=\"#000000\" header_2_font_size=\"15px\" header_2_letter_spacing=\"1px\" header_2_line_height=\"1.4em\" header_3_font=\"Gotham kinda bold|||on|||||\" header_3_text_color=\"#000000\" header_3_font_size=\"15px\" header_3_letter_spacing=\"1px\" header_3_line_height=\"1.4em\" header_4_font=\"Gotham kinda bold|||on|||||\" header_4_text_color=\"#000000\" header_4_font_size=\"17px\" header_4_letter_spacing=\"1px\" header_4_line_height=\"1.4em\" header_5_font=\"Gotham kinda bold|||on|||||\" header_5_text_color=\"#000000\" header_5_font_size=\"15px\" header_5_letter_spacing=\"1px\" header_5_line_height=\"1.4em\" header_6_font=\"Gotham kinda bold|||on|||||\" header_6_text_color=\"#000000\" header_6_font_size=\"15px\" header_6_letter_spacing=\"1px\" header_6_line_height=\"1.4em\" text_orientation=\"center\" max_width=\"800px\" module_alignment=\"center\" locked=\"off\" global_colors_info=\"{}\"]<p>Europe\u2019s position in translational regenerative medicine strengthened.<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_tilt_image src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science3shadow-2.png\" title_text=\"science3shadow\" dsm_tilt_mobile=\"on\" dsm_tilt_scale=\"1.1\" dsm_tilt_max=\"15\" dsm_use_glare=\"on\" dsm_tilt_glare=\"0.5\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/dsm_tilt_image][et_pb_text _builder_version=\"4.16\" text_font=\"Gotham kinda bold||||||||\" text_text_color=\"#000000\" text_font_size=\"16px\" text_line_height=\"1.6em\" header_font=\"Gotham kinda bold|||on|||||\" header_text_color=\"#000000\" header_font_size=\"15px\" header_letter_spacing=\"1px\" header_line_height=\"1.4em\" header_2_font=\"Gotham kinda bold|||on|||||\" header_2_text_color=\"#000000\" header_2_font_size=\"15px\" header_2_letter_spacing=\"1px\" header_2_line_height=\"1.4em\" header_3_font=\"Gotham kinda bold|||on|||||\" header_3_text_color=\"#000000\" header_3_font_size=\"15px\" header_3_letter_spacing=\"1px\" header_3_line_height=\"1.4em\" header_4_font=\"Gotham kinda bold|||on|||||\" header_4_text_color=\"#000000\" header_4_font_size=\"17px\" header_4_letter_spacing=\"1px\" header_4_line_height=\"1.4em\" header_5_font=\"Gotham kinda bold|||on|||||\" header_5_text_color=\"#000000\" header_5_font_size=\"15px\" header_5_letter_spacing=\"1px\" header_5_line_height=\"1.4em\" header_6_font=\"Gotham kinda bold|||on|||||\" header_6_text_color=\"#000000\" header_6_font_size=\"15px\" header_6_letter_spacing=\"1px\" header_6_line_height=\"1.4em\" text_orientation=\"center\" max_width=\"800px\" module_alignment=\"center\" locked=\"off\" global_colors_info=\"{}\"]<p>New therapies for major human diseases and conditions, and new approaches for therapy taken further in the development pipeline.<\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.16\" background_color=\"rgba(0,0,0,0.03)\" background_position=\"top_center\" custom_margin=\"|||\" custom_padding=\"100px||100px|\" global_colors_info=\"{}\"][et_pb_row use_custom_gutter=\"on\" gutter_width=\"4\" _builder_version=\"4.16\" custom_margin=\"||||false|false\" custom_padding=\"0px|||\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" parallax__hover=\"off\" parallax_method__hover=\"on\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Potential new regenerative therapies to address unmet clinical needs of large patient groups identified\" url=\"#\" icon_placement=\"left\" image_icon_width=\"64px\" content_max_width=\"1400px\" admin_label=\"Chapter\" _builder_version=\"4.16\" header_font=\"Gotham kinda bold||||||||\" header_text_color=\"#000000\" header_line_height=\"1.5em\" body_font=\"Gotham kinda bold||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.9em\" background_color=\"#ffffff\" custom_margin=\"|||\" custom_padding=\"30px|40px|30px|40px\" animation_style=\"zoom\" animation_direction=\"bottom\" animation_intensity_zoom=\"20%\" animation_starting_opacity=\"100%\" box_shadow_style=\"preset2\" box_shadow_horizontal=\"0px\" box_shadow_vertical=\"0px\" box_shadow_blur=\"60px\" box_shadow_color=\"rgba(10,3,3,0.06)\" image_max_width=\"64px\" locked=\"off\" global_colors_info=\"{}\"]<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">Faecal incontinence is a common condition affecting approximately 9% of adults in Europe. However, this figure is likely underestimated, as around 70% of individuals do not seek medical advice. Of those who do consult a healthcare professional, only a proportion pursue further treatment, and approximately half are not suitable for currently available options.<\/div>\n<div class=\"x_elementToProof\">The AMELIE approach offers several advantages over existing surgical interventions, which can carry risks such as infection, pain, and device failure or dislocation, sometimes resulting in the need for a permanent stoma. Improved continence outcomes have the potential to benefit not only patients, but also carers and individuals on nursing home waiting lists.<\/div>\n<div class=\"x_elementToProof\">If effective, treatment using implantable cell\u2013microcarrier technology could significantly improve quality of life for citizens across Europe. Presenting this therapy as a realistic option for restoring continence, rather than solely managing symptoms, may also encourage more patients to seek medical advice, thereby increasing access to treatment.<\/div>[\/et_pb_blurb][et_pb_blurb title=\"Europe\u2019s position in translational regenerative medicine strengthened \" url=\"#\" icon_placement=\"left\" image_icon_width=\"64px\" content_max_width=\"1400px\" admin_label=\"Chapter\" _builder_version=\"4.16\" header_font=\"Gotham kinda bold||||||||\" header_text_color=\"#000000\" header_line_height=\"1.5em\" body_font=\"Gotham kinda bold||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.9em\" background_color=\"#ffffff\" custom_margin=\"|||\" custom_padding=\"30px|40px|30px|40px\" animation_style=\"zoom\" animation_direction=\"bottom\" animation_intensity_zoom=\"20%\" animation_starting_opacity=\"100%\" box_shadow_style=\"preset2\" box_shadow_horizontal=\"0px\" box_shadow_vertical=\"0px\" box_shadow_blur=\"60px\" box_shadow_color=\"rgba(10,3,3,0.06)\" image_max_width=\"64px\" locked=\"off\" global_colors_info=\"{}\"]<p><span style=\"font-weight: 400;\">Europe is world-leading in cell-based therapies for patients with FI.<\/span> <span style=\"font-weight: 400;\">As well as reinforcing Europe\u2019s dominant role in the field, AMELIE also represents a step-change in the approach being taken to manufacture and deliver cell-based medicine that will enable European citizens to be the first worldwide to benefit from a pioneering new approach to regenerative medicine.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cell therapy is a rapidly growing area of research. Tissue engineered products are set to grow significantly and provide substantial opportunities to strengthen Europe\u2019s position in translational regenerative medicine. Europe is responsible for approximately 26% of global regenerative medicine companies. The development of innovative technology such as implantable TIPS microcarriers will draw investment to Europe. AMELIE then seeks to advance the competitive positions of European companies as providers of innovative enabling technologies for regenerative medicine. This will enhance AMELIE\u2019s exploitative potential.<\/span><\/p>[\/et_pb_blurb][et_pb_blurb title=\"New therapies for major human diseases and conditions, and new approaches for therapy taken further in the development pipeline\" url=\"#\" icon_placement=\"left\" image_icon_width=\"64px\" content_max_width=\"1400px\" admin_label=\"Chapter\" _builder_version=\"4.16\" header_font=\"Gotham kinda bold||||||||\" header_text_color=\"#000000\" header_line_height=\"1.5em\" body_font=\"Gotham kinda bold||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.9em\" background_color=\"#ffffff\" custom_margin=\"|||\" custom_padding=\"30px|40px|30px|40px\" animation_style=\"zoom\" animation_direction=\"bottom\" animation_intensity_zoom=\"20%\" animation_starting_opacity=\"100%\" box_shadow_style=\"preset2\" box_shadow_horizontal=\"0px\" box_shadow_vertical=\"0px\" box_shadow_blur=\"60px\" box_shadow_color=\"rgba(10,3,3,0.06)\" image_max_width=\"64px\" locked=\"off\" global_colors_info=\"{}\"]<p><span style=\"font-weight: 400;\">AMELIE paves the way for identical or similar innovative treatments using ASMDC cell-microcarrier combinations for a variety of other clinical conditions associated with loss of skeletal muscle function, such as urinary incontinence, muscular dystrophies and volumetric muscle loss associated with trauma injury.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The same scientific rationale and new approach developed in AMELIE is equally applicable to other anchorage-dependent cell types investigated as new regenerative medicine treatments. New products comprised of these anchorage-dependent cells are intended to treat some of the most debilitating diseases that affect muscle, bone, cartilage, ocular, heart\/cardiovascular, gastrointestinal\/liver, kidney, immune and respiratory tissues. Adoption of the implantable TIPS microcarrier technology could have a significant impact on their outcome.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Meanwhile the scale-up manufacturing process for TIPS microparticles developed can be applied to other uses of the microparticle technology currently being investigated in the development pipeline. <\/span><\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_section]","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-31818","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/pages\/31818","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/comments?post=31818"}],"version-history":[{"count":8,"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/pages\/31818\/revisions"}],"predecessor-version":[{"id":31830,"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/pages\/31818\/revisions\/31830"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/media?parent=31818"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}