{"id":30450,"date":"2020-12-16T16:08:01","date_gmt":"2020-12-16T16:08:01","guid":{"rendered":"https:\/\/amelie-project.eu\/?page_id=30450"},"modified":"2026-07-01T10:12:20","modified_gmt":"2026-07-01T10:12:20","slug":"nuestra-investigacion","status":"publish","type":"page","link":"https:\/\/amelie-project.eu\/es\/nuestra-investigacion\/","title":{"rendered":"Nuestra investigaci\u00f3n"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Hero section&#8221; _builder_version=&#8221;4.16&#8243; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/AMELIEHEADERBACKGOUND-01-scaled.jpg&#8221; background_position=&#8221;center_left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;7%||7%||true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row use_custom_gutter=&#8221;on&#8221; 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custom_padding_phone=&#8221;||||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; header_font_size_tablet=&#8221;5vw&#8221; header_font_size_phone=&#8221;6vw&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_block_reveal_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; admin_label=&#8221;Collections&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;100px|0px|100px|0px|false|false&#8221; custom_padding_tablet=&#8221;50px||50px||true|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; make_equal=&#8221;on&#8221; custom_padding_last_edited=&#8221;off|tablet&#8221; module_id=&#8221;faecal-incontinence-about-the-condition&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_margin_tablet=&#8221;||||false|false&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|tablet&#8221; custom_padding=&#8221;0px||0px|&#8221; box_shadow_style=&#8221;preset3&#8243; box_shadow_vertical=&#8221;40px&#8221; box_shadow_blur=&#8221;50px&#8221; box_shadow_color=&#8221;rgba(0,0,0,0.1)&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_direction=&#8221;35deg&#8221; background_color_gradient_stops=&#8221;#6bc8ff 0%|#99afff 100%&#8221; background_color_gradient_start=&#8221;#6bc8ff&#8221; background_color_gradient_end=&#8221;#99afff&#8221; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/12\/Asset-1.png&#8221; custom_padding=&#8221;5%|5%|5%|5%|true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;40px|40px|40px|40px&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;AMELIE||||||||&#8221; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_3_font=&#8221;Gotham kinda bold||||||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;28px&#8221; header_3_line_height=&#8221;1.5em&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||10px|&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Incontinencia fecal: repercusiones en los pacientes<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.9em&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">La incontinencia fecal es un problema de salud p\u00fablica de gran envergadura. <\/span>Esta afecci\u00f3n puede afectar gravemente a la vida cotidiana, por ejemplo:<\/p>\n<ul>\n<li>dignidad y confianza<\/li>\n<li>bienestar y salud mental<\/li>\n<li>independencia<\/li>\n<\/ul>\n<div class=\"x_elementToProof\">Muchas personas experimentan:<\/div>\n<ul>\n<li>ansiedad<\/li>\n<li>aislamiento social<\/li>\n<li>menor participaci\u00f3n en el trabajo y en los desplazamientos<\/li>\n<li>limitaciones en las actividades cotidianas<\/li>\n<\/ul>\n<div class=\"x_elementToProof\">El proyecto AMELIE se centra espec\u00edficamente en la incontinencia fecal derivada de una lesi\u00f3n del esf\u00ednter anal, que suele producirse tras:<\/div>\n<ul>\n<li>parto<\/li>\n<li>cirug\u00eda<\/li>\n<li>trauma<\/li>\n<\/ul>\n<div class=\"x_elementToProof\">Las mujeres que han dado a luz representan una gran proporci\u00f3n de las personas afectadas, ya que alrededor de 5,5% sufren lesiones directas durante el parto debido a desgarros perineales.<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|tablet&#8221; admin_label=&#8221;Collections&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;0px|0px|100px|0px|false|false&#8221; custom_padding_tablet=&#8221;||50px||false|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;3_5,2_5&#8243; make_equal=&#8221;on&#8221; module_id=&#8221;faecal-incontinence-and-regenerative-medicine&#8221; _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;0px||0px|&#8221; hover_enabled=&#8221;0&#8243; box_shadow_style=&#8221;preset3&#8243; box_shadow_vertical=&#8221;40px&#8221; box_shadow_blur=&#8221;50px&#8221; box_shadow_color=&#8221;rgba(0,0,0,0.1)&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_column type=&#8221;3_5&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;40px|40px|40px|40px&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; custom_css_main_element_last_edited=&#8221;off|phone&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;AMELIE||||||||&#8221; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_3_font=&#8221;Gotham kinda bold||||||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;28px&#8221; header_3_line_height=&#8221;1.5em&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||10px|&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Incontinencia fecal y medicina regenerativa<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.9em&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">\n<p>La medicina regenerativa tiene como objetivo reparar o sustituir el tejido da\u00f1ado por el envejecimiento, una enfermedad o una lesi\u00f3n, lo que ofrece nuevas posibilidades para el tratamiento de la incontinencia fecal provocada por una lesi\u00f3n en el esf\u00ednter anal. Entre los enfoques regenerativos, la terapia celular que utiliza c\u00e9lulas aut\u00f3logas derivadas del m\u00fasculo esquel\u00e9tico (ASMDC) para regenerar el esf\u00ednter anal externo da\u00f1ado ha sido la m\u00e1s investigada.<\/p>\n<\/div>\n<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\"><\/div>\n<div class=\"x_elementToProof\">Europa ha desempe\u00f1ado un papel destacado a la hora de trasladar este enfoque a la pr\u00e1ctica cl\u00ednica. De los cinco estudios cl\u00ednicos publicados sobre terapia celular para la incontinencia fecal, tres fueron realizados por grupos de investigaci\u00f3n europeos y utilizaron ASMDC administradas en forma de suspensi\u00f3n celular. En el ensayo aleatorizado de fase II controlado con placebo, solo el 58% de los pacientes que recibieron terapia con ASMDC respondieron al tratamiento tras 12 meses, mientras que los estudios piloto abiertos informaron de niveles similares de mejora subjetiva. En general, estos estudios han demostrado un beneficio cl\u00ednico moderado, lo que sugiere que los m\u00e9todos actuales de administraci\u00f3n celular no logran de forma sistem\u00e1tica el efecto terap\u00e9utico deseado.<\/div>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_direction=&#8221;35deg&#8221; background_color_gradient_stops=&#8221;#6bc8ff 0%|#99afff 100%&#8221; background_color_gradient_start=&#8221;#6bc8ff&#8221; background_color_gradient_end=&#8221;#99afff&#8221; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/12\/Asset-3.png&#8221; custom_padding=&#8221;5%|5%|5%|5%|true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; custom_css_main_element_last_edited=&#8221;off|desktop&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|tablet&#8221; admin_label=&#8221;Collections&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;0px|0px|100px|0px|false|false&#8221; custom_padding_tablet=&#8221;||100px||false|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; make_equal=&#8221;on&#8221; module_id=&#8221;why-are-conventional-methods-not-working&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;0px||0px|&#8221; box_shadow_style=&#8221;preset3&#8243; box_shadow_vertical=&#8221;40px&#8221; box_shadow_blur=&#8221;50px&#8221; box_shadow_color=&#8221;rgba(0,0,0,0.1)&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_direction=&#8221;35deg&#8221; background_color_gradient_stops=&#8221;#6bc8ff 0%|#99afff 100%&#8221; background_color_gradient_start=&#8221;#6bc8ff&#8221; background_color_gradient_end=&#8221;#99afff&#8221; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/12\/Asset-2.png&#8221; custom_padding=&#8221;5%|5%|5%|5%|true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;40px|40px|40px|40px&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;AMELIE||||||||&#8221; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_3_font=&#8221;Gotham kinda bold||||||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;28px&#8221; header_3_line_height=&#8221;1.5em&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||10px|&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>\u00bfPor qu\u00e9 los m\u00e9todos convencionales no ofrecen mejores resultados?<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.9em&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">Muchas de las c\u00e9lulas que se utilizan en medicina regenerativa, incluidas las c\u00e9lulas aut\u00f3logas derivadas del m\u00fasculo esquel\u00e9tico (ASMDC), son<span>\u00a0<\/span><b>dependiente del anclaje<\/b>, lo que significa que deben permanecer adheridas a una superficie para crecer y funcionar con normalidad. En los procesos de fabricaci\u00f3n convencionales, estas c\u00e9lulas se extraen del paciente, se multiplican en el laboratorio mientras permanecen adheridas a una superficie de cultivo y, posteriormente, se desprenden antes de administrarse en forma de suspensi\u00f3n celular.<\/div>\n<div class=\"x_elementToProof\">Hasta la fecha, todos los estudios cl\u00ednicos publicados sobre la terapia celular para la incontinencia fecal han utilizado este m\u00e9todo de fabricaci\u00f3n convencional. Sin embargo, separar las c\u00e9lulas de su superficie de cultivo antes del trasplante puede da\u00f1arlas, reduciendo su viabilidad y su potencial regenerativo. Este proceso tambi\u00e9n puede desencadenar el anoikis, una forma de muerte celular que se produce cuando las c\u00e9lulas dependientes del anclaje pierden contacto con su superficie de soporte.<\/div>\n<div class=\"x_elementToProof\">La baja supervivencia celular tras el trasplante es uno de los principales retos a los que se enfrenta la medicina regenerativa. En el caso de las terapias que se basan en la integraci\u00f3n de las c\u00e9lulas en el m\u00fasculo da\u00f1ado, como los tratamientos para la incontinencia fecal, una baja supervivencia celular puede limitar su eficacia y contribuir a que los resultados cl\u00ednicos sean irregulares.<\/div>\n<div class=\"x_elementToProof\">Abordar este reto constituye el n\u00facleo del proyecto AMELIE. Mediante el desarrollo de una terapia con microportadores celulares implantables que permita que las c\u00e9lulas permanezcan adheridas a un andamio de soporte durante el trasplante, el consorcio pretende mejorar la supervivencia celular, potenciar la reparaci\u00f3n tisular y lograr mejores resultados para los pacientes.<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module dsm_block_reveal_text dsm_block_reveal_text_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm_block_reveal_text_wrapper\" data-dsm-block-reveal-animation=\"lr\" data-dsm-block-reveal-color=\"#0e94f9\" data-dsm-block-reveal-delay=\"0\" data-dsm-block-reveal-viewport=\"80%\"><h1 class=\"dsm_block_reveal_text_header et_pb_module_header\">NUESTRA INVESTIGACI\u00d3N<\/h1><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Faecal Incontinence: Impact on PatientsFaecal incontinence is a substantial public health problem. The condition can severely affect everyday life, including: dignity and confidence wellbeing and mental health independence Many individuals experience: anxiety social isolation reduced participation in work and travel limitations in daily activities The AMELIE project focuses specifically on faecal incontinence resulting from injury to the anal sphincter, most commonly following: childbirth surgery trauma Women who have given birth represent a large proportion of affected individuals, with around 5.5% experiencing direct injury during childbirth due to perineal tearing.Faecal Incontinence and Regenerative Medicine Regenerative medicine seeks to repair or replace tissue that has been damaged by ageing, disease or injury, offering new possibilities for treating faecal incontinence caused by injury to the anal sphincter. Among regenerative approaches, cell therapy using autologous skeletal muscle-derived cells (ASMDCs) to regenerate the damaged external anal sphincter has been the most extensively investigated. Europe has played a leading role in translating this approach into clinical practice. Of the five published clinical studies of cell therapy for faecal incontinence, three were conducted by European research groups and used [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-30450","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/pages\/30450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/comments?post=30450"}],"version-history":[{"count":23,"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/pages\/30450\/revisions"}],"predecessor-version":[{"id":31786,"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/pages\/30450\/revisions\/31786"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/es\/wp-json\/wp\/v2\/media?parent=30450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}