{"id":31461,"date":"2023-10-09T16:23:22","date_gmt":"2023-10-09T16:23:22","guid":{"rendered":"https:\/\/amelie-project.eu\/?post_type=publication&#038;p=31461"},"modified":"2024-02-26T16:30:40","modified_gmt":"2024-02-26T16:30:40","slug":"veroffentlichung-4","status":"publish","type":"publication","link":"https:\/\/amelie-project.eu\/de\/veroffentlichung\/veroffentlichung-4\/","title":{"rendered":"Ringe mit Kugeln bauen: ein zelltherapeutischer Ansatz bei Inkontinenz"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_row _builder_version=&#8221;4.21.0&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221; width=&#8221;100%&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<!-- divi:paragraph --><\/p>\n<p><strong>Martha Gilbert, Simona \u010caputov\u00e1, Delielena Poli, Manou Kooy, Georgia Sturt, Josephine Parker und Richard M Day.<\/strong><\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p>Zell- und Gentherapie Einblicke 2023; 9(10), 1293-1306.<\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p>Stuhlinkontinenz ist ein weit verbreitetes Leiden, \u00fcber das immer noch viel zu wenig berichtet wird. Die Erkrankung beeintr\u00e4chtigt die Lebensqualit\u00e4t der Patienten und hat negative sozio\u00f6konomische und \u00f6kologische Auswirkungen auf die Gesellschaft. Die aktuellen Leitlinien f\u00fcr die Behandlung von Patienten empfehlen ein schrittweises Vorgehen bei der Behandlung von Stuhlinkontinenz, von konservativen Behandlungsm\u00f6glichkeiten \u00fcber minimalinvasive chirurgische Optionen bis hin zu chirurgischen Optionen der ersten und zweiten Wahl. Leider sind die konservativen Behandlungen nach wie vor unwirksam, und in vielen F\u00e4llen sind die chirurgischen Optionen entweder nicht erw\u00fcnscht oder nicht geeignet. Die regenerative Medizin, insbesondere die Zelltherapie, hat das Potenzial, eine weniger invasive, effektivere und effizientere Heilbehandlung zu bieten. Zelltherapietechnologien befinden sich zwar noch in der Entwicklung, k\u00f6nnen aber den derzeitigen Stand der Dinge im Bereich der Stuhlinkontinenz auf klinischer, patientenseitiger und sozio\u00f6konomischer Ebene verbessern. Dieser Artikel verfolgt ein zweifaches Ziel. Erstens soll er das Bewusstsein f\u00fcr das stille Leiden der Stuhlinkontinenz und f\u00fcr die Auswirkungen auf die Patienten und die Gesellschaft sch\u00e4rfen. Zweitens soll die Zelltherapie im Vergleich zu den derzeitigen Behandlungsans\u00e4tzen, wie z. B. der Stimulation des Sakralnervs und der Sphinkterplastik, positioniert werden, um ihr Potenzial als geeignete Behandlungsalternative hervorzuheben. <\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p>Hier finden Sie das vollst\u00e4ndige Papier:<\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p><!-- divi:paragraph --><\/p>\n<p><a href=\"https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence\">https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence<\/a><\/p>\n<p><!-- \/divi:paragraph -->[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p>Martha Gilbert, Simona \u010caputov\u00e1, Delielena Poli, Manou Kooy, Georgia Sturt, Josephine Parker and Richard M Day. Cell &amp; Gene Therapy Insights 2023; 9(10), 1293\u20131306. Fecal incontinence is a prevalent condition, that remains vastly underreported. The condition impacts the patients\u2019 quality of life and has negative socio-economic and environmental impact on the society. Current patient management guidelines recommend a stepwise approach to treating fecal incontinence, from conservative treatment options, through minimally invasive surgical options, all the way to first- and second-line surgical options. Unfortunately, the conservative treatments remain ineffective, and, in many cases, the surgical options are either not desirable or not suitable. Regenerative medicine, and specifically, cell therapy, has the potential to offer a curative treatment that is less invasive, more effective and efficient. Cell therapy technologies, while still under development, can improve the current state-of-play in the realm of fecal incontinence at the clinical, patient, and socio-economic level. The aim of this article is twofold. Firstly, it is to raise awareness about the silent affliction that fecal incontinence is and about the impact that it has on patients and society. Secondly, it is to position cell therapy, relative to the current treatment approaches, including, for example, sacral nerve stimulation [&hellip;]<\/p>","protected":false},"featured_media":31463,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<!-- wp:paragraph -->\n<p><strong>Martha Gilbert, Simona \u010caputov\u00e1, Delielena Poli, Manou Kooy, Georgia Sturt, Josephine Parker and Richard M Day.<\/strong><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Cell &amp; Gene Therapy Insights 2023; 9(10), 1293\u20131306.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Fecal incontinence is a prevalent condition, that remains vastly underreported. The condition impacts the patients\u2019 quality of life and has negative socio-economic and environmental impact on the society. Current patient management guidelines recommend a stepwise approach to treating fecal incontinence, from conservative treatment options, through minimally invasive surgical options, all the way to first- and second-line surgical options. Unfortunately, the conservative treatments remain ineffective, and, in many cases, the surgical options are either not desirable or not suitable. Regenerative medicine, and specifically, cell therapy, has the potential to offer a curative treatment that is less invasive, more effective and efficient. Cell therapy technologies, while still under development, can improve the current state-of-play in the realm of fecal incontinence at the clinical, patient, and socio-economic level. The aim of this article is twofold. Firstly, it is to raise awareness about the silent affliction that fecal incontinence is and about the impact that it has on patients and society. Secondly, it is to position cell therapy, relative to the current treatment approaches, including, for example, sacral nerve stimulation and sphincteroplasty, as to emphasize its potential to provide a suitable treatment alternative. <\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Access the full paper here:<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><a href=\"https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence\">https:\/\/www.insights.bio\/cell-and-gene-therapy-insights\/journal\/article\/3016\/Building-rings-with-spheres-a-cell-therapy-approach-to-incontinence<\/a><\/p>\n<!-- \/wp:paragraph -->","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_links_to":"","_links_to_target":""},"categories":[43],"class_list":["post-31461","publication","type-publication","status-publish","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/publication\/31461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/types\/publication"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/media\/31463"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/media?parent=31461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/categories?post=31461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}