{"id":29994,"date":"2023-09-10T09:09:36","date_gmt":"2023-09-10T09:09:36","guid":{"rendered":"https:\/\/amelie-project.eu\/?post_type=category-publication&p=29994"},"modified":"2024-02-26T16:22:58","modified_gmt":"2024-02-26T16:22:58","slug":"veroffentlichung-3","status":"publish","type":"publication","link":"https:\/\/amelie-project.eu\/de\/veroffentlichung\/veroffentlichung-3\/","title":{"rendered":"\u00dcberlegungen zur Bioprozessierung bei der Herstellung von therapeutischen Skelett- und glatten Muskelzellen"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.21.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.21.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral and Cl\u00e1udia L da Silva.<\/strong><\/p>\n

Bioengineering. 2023;10(9):1067.<\/p>\n

Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle or smooth muscle, responsible for involuntary and voluntary contraction, respectively. In this review, several features and parameters involved in the bioprocessing of muscle cells are addressed. The cell isolation process is depicted, depending on the type of tissue (smooth or skeletal muscle), followed by the description of the challenges involving the use of adult donor tissue and the strategies to overcome the hurdles of reaching relevant cell numbers towards a clinical application. Specifically, the use of stem\/progenitor cells is highlighted as a source for smooth and skeletal muscle cells towards the development of a cellular product able to maintain the target cell\u2019s identity and functionality. Moreover, taking into account the need for a robust and cost-effective bioprocess for cell manufacturing, the combination of muscle cells with biomaterials and the need for scale-up envisioning clinical applications are also approached.<\/p>\n

<\/p>\n

Access the full paper here:<\/p>\n

<\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/a><\/p>\n

<\/p>\n

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Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral and Cl\u00e1udia L da Silva. Bioengineering. 2023;10(9):1067. Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle or smooth muscle, responsible for involuntary and voluntary contraction, respectively. In this review, several features and parameters involved in the bioprocessing of muscle cells are addressed. The cell isolation process is depicted, depending on the type of tissue (smooth or skeletal muscle), followed by the description of the challenges involving the use of adult donor tissue and the strategies to overcome the hurdles of reaching relevant cell numbers towards a clinical application. Specifically, the use of stem\/progenitor cells is highlighted as a source for smooth and skeletal muscle cells towards the development of a cellular product able to maintain the target cell\u2019s identity and functionality. Moreover, taking into account the need for a robust and cost-effective bioprocess for cell manufacturing, the combination of muscle cells with biomaterials and the need for scale-up envisioning clinical applications are also approached. Access the full paper here: https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/p>","protected":false},"featured_media":31459,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\n

Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral and Cl\u00e1udia L da Silva.
Bioengineering. 2023;10(9):1067.<\/strong><\/p>\n\n\n\n

Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle or smooth muscle, responsible for involuntary and voluntary contraction, respectively. In this review, several features and parameters involved in the bioprocessing of muscle cells are addressed. The cell isolation process is depicted, depending on the type of tissue (smooth or skeletal muscle), followed by the description of the challenges involving the use of adult donor tissue and the strategies to overcome the hurdles of reaching relevant cell numbers towards a clinical application. Specifically, the use of stem\/progenitor cells is highlighted as a source for smooth and skeletal muscle cells towards the development of a cellular product able to maintain the target cell\u2019s identity and functionality. Moreover, taking into account the need for a robust and cost-effective bioprocess for cell manufacturing, the combination of muscle cells with biomaterials and the need for scale-up envisioning clinical applications are also approached.<\/p>\n\n\n\n

Access the full paper here:\u00a0<\/p>\n\n\n\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/a><\/p>\n","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_links_to":"","_links_to_target":""},"categories":[43],"class_list":["post-29994","publication","type-publication","status-publish","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/publication\/29994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/types\/publication"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/media\/31459"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/media?parent=29994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/categories?post=29994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}