{"id":29994,"date":"2023-09-10T09:09:36","date_gmt":"2023-09-10T09:09:36","guid":{"rendered":"https:\/\/amelie-project.eu\/?post_type=category-publication&p=29994"},"modified":"2024-02-26T16:22:58","modified_gmt":"2024-02-26T16:22:58","slug":"veroffentlichung-3","status":"publish","type":"publication","link":"https:\/\/amelie-project.eu\/de\/veroffentlichung\/veroffentlichung-3\/","title":{"rendered":"\u00dcberlegungen zur Bioprozessierung bei der Herstellung von therapeutischen Skelett- und glatten Muskelzellen"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.21.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.21.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral und Cl\u00e1udia L da Silva.<\/strong><\/p>\n

Bioengineering. 2023;10(9):1067.<\/p>\n

Tissue-Engineering-Ans\u00e4tze im Muskelbereich stellen ein vielversprechendes neues Feld dar, um die aktuellen therapeutischen Herausforderungen zu bew\u00e4ltigen, die mit zahlreichen pathologischen Zust\u00e4nden verbunden sind, die die Muskelkompartimente betreffen, entweder die Skelettmuskulatur oder die glatte Muskulatur, die f\u00fcr die unwillk\u00fcrliche bzw. willentliche Kontraktion verantwortlich sind. In dieser \u00dcbersicht werden verschiedene Merkmale und Parameter der Bioprozessierung von Muskelzellen behandelt. Je nach Gewebetyp (glatte Muskulatur oder Skelettmuskulatur) wird der Prozess der Zellisolierung dargestellt, gefolgt von der Beschreibung der Herausforderungen, die mit der Verwendung von adultem Spendergewebe verbunden sind, und den Strategien zur \u00dcberwindung der H\u00fcrden beim Erreichen relevanter Zellzahlen f\u00fcr eine klinische Anwendung. Insbesondere wird die Verwendung von Stamm-\/Vorl\u00e4uferzellen als Quelle f\u00fcr glatte und Skelettmuskelzellen hervorgehoben, um ein zellul\u00e4res Produkt zu entwickeln, das in der Lage ist, die Identit\u00e4t und Funktionalit\u00e4t der Zielzellen zu erhalten. Unter Ber\u00fccksichtigung der Notwendigkeit eines robusten und kosteneffizienten Bioprozesses f\u00fcr die Zellherstellung werden auch die Kombination von Muskelzellen mit Biomaterialien und der Bedarf an Scale-up f\u00fcr klinische Anwendungen angesprochen.<\/p>\n

<\/p>\n

Hier finden Sie das vollst\u00e4ndige Papier:<\/p>\n

<\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/a><\/p>\n

<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral and Cl\u00e1udia L da Silva. Bioengineering. 2023;10(9):1067. Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle or smooth muscle, responsible for involuntary and voluntary contraction, respectively. In this review, several features and parameters involved in the bioprocessing of muscle cells are addressed. The cell isolation process is depicted, depending on the type of tissue (smooth or skeletal muscle), followed by the description of the challenges involving the use of adult donor tissue and the strategies to overcome the hurdles of reaching relevant cell numbers towards a clinical application. Specifically, the use of stem\/progenitor cells is highlighted as a source for smooth and skeletal muscle cells towards the development of a cellular product able to maintain the target cell\u2019s identity and functionality. Moreover, taking into account the need for a robust and cost-effective bioprocess for cell manufacturing, the combination of muscle cells with biomaterials and the need for scale-up envisioning clinical applications are also approached. Access the full paper here: https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/p>","protected":false},"featured_media":31459,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\n

Teresa Franchi-Mendes, Mar\u00edlia Silva, Ana Lu\u00edsa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M S Cabral and Cl\u00e1udia L da Silva.
Bioengineering. 2023;10(9):1067.<\/strong><\/p>\n\n\n\n

Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle or smooth muscle, responsible for involuntary and voluntary contraction, respectively. In this review, several features and parameters involved in the bioprocessing of muscle cells are addressed. The cell isolation process is depicted, depending on the type of tissue (smooth or skeletal muscle), followed by the description of the challenges involving the use of adult donor tissue and the strategies to overcome the hurdles of reaching relevant cell numbers towards a clinical application. Specifically, the use of stem\/progenitor cells is highlighted as a source for smooth and skeletal muscle cells towards the development of a cellular product able to maintain the target cell\u2019s identity and functionality. Moreover, taking into account the need for a robust and cost-effective bioprocess for cell manufacturing, the combination of muscle cells with biomaterials and the need for scale-up envisioning clinical applications are also approached.<\/p>\n\n\n\n

Access the full paper here:\u00a0<\/p>\n\n\n\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37760170\/<\/a><\/p>\n","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_links_to":"","_links_to_target":""},"categories":[43],"class_list":["post-29994","publication","type-publication","status-publish","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/publication\/29994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/types\/publication"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/media\/31459"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/media?parent=29994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/categories?post=29994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}