{"id":31811,"date":"2026-07-01T15:31:55","date_gmt":"2026-07-01T15:31:55","guid":{"rendered":"https:\/\/amelie-project.eu\/?p=31811"},"modified":"2026-07-01T15:35:57","modified_gmt":"2026-07-01T15:35:57","slug":"aktuelles-zum-amelie-projekt-meilensteine-in-der-fruhen-klinischen-studie-erreicht","status":"publish","type":"post","link":"https:\/\/amelie-project.eu\/de\/aktuelles-zum-amelie-projekt-meilensteine-in-der-fruhen-klinischen-studie-erreicht\/","title":{"rendered":"AMELIE-Projekt-Update: Erste Meilensteine der klinischen Studie erreicht"},"content":{"rendered":"[et_pb_section fb_built=\u201d1\u2033 admin_label=\u201dsection\u201d _builder_version=\u201d4.16\u2033 global_colors_info=\u201d{}\u201d theme_builder_area=\u201dpost_content\u201d][et_pb_row admin_label=\u201drow\u201d _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d custom_padding=\u201d|||0px||\u201d global_colors_info=\u201d{}\u201d theme_builder_area=\u201dpost_content\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d theme_builder_area=\u201dpost_content\u201d][et_pb_text admin_label=\u201dText\u201d _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d global_colors_info=\u201d{}\u201d theme_builder_area=\u201dpost_content\u201d]
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Wir freuen uns, Ihnen einen wichtigen Meilenstein im AMELIE-Projekt vorstellen zu d\u00fcrfen, in dessen Rahmen eine neuartige regenerative Behandlungsmethode f\u00fcr Stuhlinkontinenz entwickelt wird.

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Bislang wurden im Rahmen der laufenden klinischen Studie vier Patienten im Royal London Hospital in London und zwei Patienten im University Hospital of Wales in Cardiff behandelt.<\/p>\n<\/div>\n

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Dies stellt einen bedeutenden Fortschritt bei der Bewertung einer neuen zellbasierten Therapie dar, die darauf abzielt, die Schlie\u00dfmuskelfunktion wiederherzustellen, indem autologe, aus Skelettmuskelzellen gewonnene Zellen verwendet werden, die an implantierbaren Mikrotr\u00e4gern befestigt sind. Der Ansatz zielt darauf ab, das \u00dcberleben der Zellen zu verbessern, die Gewebereparatur zu unterst\u00fctzen und letztendlich die Kontinenzergebnisse f\u00fcr Patienten mit dieser schwierigen Erkrankung zu verbessern.<\/p>\n<\/div>\n


Jeder Behandlungsablauf beginnt mit einer Muskelbiopsie, um die f\u00fcr die Herstellung der personalisierten Therapie erforderlichen Zellen zu entnehmen. Diese Zellen werden anschlie\u00dfend aufbereitet und f\u00fcr die Implantation vorbereitet, bevor sie dem Patienten an einer der teilnehmenden klinischen Einrichtungen wieder verabreicht werden.<\/div>\n

Die Behandlung dieser sechs Patienten stellt einen wichtigen Meilenstein bei der Umsetzung von AMELIE von der Laborentwicklung in die klinische Praxis dar. Sie spiegelt zudem die enge Zusammenarbeit zwischen Chirurgen, Wissenschaftlern, Produktionsteams und Mitarbeitern klinischer Studien in ganz Gro\u00dfbritannien wider.<\/div>\n

Im Verlauf der Studie wird das Team die Ergebnisse weiterhin sorgf\u00e4ltig beobachten, um die Sicherheit und erste Anzeichen f\u00fcr die Wirksamkeit zu bewerten.<\/div>\n

Wir freuen uns darauf, Ihnen im weiteren Verlauf dieser bahnbrechenden Studie weitere Neuigkeiten mitzuteilen.<\/div>\n
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<\/em><\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]","protected":false},"excerpt":{"rendered":"

We are pleased to share an important milestone in the AMELIE project, which is developing a novel regenerative treatment for faecal incontinence. To date, four patients have been treated at The Royal London Hospital in London, and two patients have been treated at the University Hospital of Wales in Cardiff as part of the ongoing clinical trial. This marks a significant step forward in the evaluation of a new cell-based therapy that aims to restore sphincter function by using autologous skeletal muscle-derived cells attached to implantable microcarriers. The approach is designed to improve cell survival, support tissue repair, and ultimately improve continence outcomes for patients living with this challenging condition. Each patient pathway begins with a muscle biopsy to collect the cells needed to manufacture the personalised therapy. These cells are then processed and prepared for implantation, before being delivered back to the patient at one of the participating clinical sites. The treatment of these six patients represents a key milestone in the translation of AMELIE from laboratory development into clinical practice. It also reflects the close collaboration between surgeons, scientists, manufacturing teams, and clinical trial staff across the UK. As the trial progresses, the team will continue carefully monitor […]<\/p>","protected":false},"author":6,"featured_media":31815,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" admin_label=\"section\" _builder_version=\"4.16\" global_colors_info=\"{}\" theme_builder_area=\"post_content\"][et_pb_row admin_label=\"row\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_padding=\"|||0px||\" global_colors_info=\"{}\" theme_builder_area=\"post_content\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" custom_padding__hover=\"|||\" theme_builder_area=\"post_content\"][et_pb_text admin_label=\"Text\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" global_colors_info=\"{}\" theme_builder_area=\"post_content\"]

The first patient was recently treated in the AMELIE clinical trial during April 2026. The team at The Royal London Hospital implanted healthy muscle cells attached to microscopic beads in humans for the first time. The study aims to treat faecal incontinence caused by childbirth injury.<\/span><\/p>\n

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The first patients had been biopsied two weeks prior to this in Cardiff at the University Hospital of Wales.<\/p>\n

These are important milestones for the progression of this groundbreaking treatment. The team looks forward to treating the remaining patients enrolled in the trial in the coming months.<\/p>\n<\/div>\n

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