{"id":31818,"date":"2026-07-02T09:56:49","date_gmt":"2026-07-02T09:56:49","guid":{"rendered":"https:\/\/amelie-project.eu\/?page_id=31818"},"modified":"2026-07-02T09:56:52","modified_gmt":"2026-07-02T09:56:52","slug":"stuhlinkontinenz-in-europa-pravalenz-und-hauptursachen","status":"publish","type":"page","link":"https:\/\/amelie-project.eu\/de\/stuhlinkontinenz-in-europa-pravalenz-und-hauptursachen\/","title":{"rendered":"Stuhlinkontinenz in Europa: Pr\u00e4valenz und Hauptursachen"},"content":{"rendered":"[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Hero section&#8221; _builder_version=&#8221;4.16&#8243; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/AMELIEHEADERBACKGOUND-01-scaled.jpg&#8221; background_position=&#8221;center_left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;7%||7%||true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; 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header_font_size=&#8221;4vw&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_tablet=&#8221;||||false|false&#8221; custom_padding_phone=&#8221;||||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; hover_enabled=&#8221;0&#8243; header_font_size_tablet=&#8221;8vw&#8221; header_font_size_phone=&#8221;10vw&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/dsm_block_reveal_text][dsm_block_reveal_text block_reveal_text=&#8221;AND MAJOR CAUSES&#8221; block_reveal_color=&#8221;#0e94f9&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;AMELIE||||||||&#8221; header_text_color=&#8221;#0e94f9&#8243; header_font_size=&#8221;3vw&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_tablet=&#8221;||||false|false&#8221; custom_padding_phone=&#8221;||||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; hover_enabled=&#8221;0&#8243; header_font_size_tablet=&#8221;6vw&#8221; header_font_size_phone=&#8221;7vw&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][\/dsm_block_reveal_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.16&#8243; transform_scale_tablet=&#8221;90%|90%&#8221; transform_scale_last_edited=&#8221;off|desktop&#8221; transform_translate_last_edited=&#8221;off|desktop&#8221; transform_rotate_last_edited=&#8221;off|desktop&#8221; transform_skew_last_edited=&#8221;off|desktop&#8221; transform_origin_last_edited=&#8221;off|desktop&#8221; transform_styles_last_edited=&#8221;off|desktop&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;100px|0px|100px|0px&#8221; custom_padding_tablet=&#8221;35px|0px|35px|0px|true|false&#8221; custom_padding_phone=&#8221;15px||15px||true|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_slide=&#8221;11%&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_tilt_image src=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science1shadow-4.png&#8221; title_text=&#8221;science1shadow&#8221; dsm_tilt_mobile=&#8221;on&#8221; dsm_tilt_scale=&#8221;1.1&#8243; dsm_tilt_max=&#8221;15&#8243; dsm_use_glare=&#8221;on&#8221; dsm_tilt_glare=&#8221;0.5&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_tilt_image][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;15px&#8221; header_letter_spacing=&#8221;1px&#8221; header_line_height=&#8221;1.4em&#8221; header_2_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;15px&#8221; header_2_letter_spacing=&#8221;1px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;15px&#8221; header_3_letter_spacing=&#8221;1px&#8221; header_3_line_height=&#8221;1.4em&#8221; header_4_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_4_text_color=&#8221;#000000&#8243; header_4_font_size=&#8221;17px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.4em&#8221; header_5_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_5_text_color=&#8221;#000000&#8243; header_5_font_size=&#8221;15px&#8221; header_5_letter_spacing=&#8221;1px&#8221; header_5_line_height=&#8221;1.4em&#8221; header_6_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_6_text_color=&#8221;#000000&#8243; header_6_font_size=&#8221;15px&#8221; header_6_letter_spacing=&#8221;1px&#8221; header_6_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;800px&#8221; module_alignment=&#8221;center&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>Stuhlinkontinenz ist weit verbreitet, wird jedoch selten gemeldet und kann <strong>die Lebensqualit\u00e4t erheblich beeintr\u00e4chtigen<\/strong>, soziale Funktionsf\u00e4higkeit und Inanspruchnahme von Gesundheitsleistungen<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_tilt_image src=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science2shadow.png&#8221; title_text=&#8221;science2shadow&#8221; dsm_tilt_mobile=&#8221;on&#8221; dsm_tilt_scale=&#8221;1.1&#8243; dsm_tilt_max=&#8221;15&#8243; dsm_use_glare=&#8221;on&#8221; dsm_tilt_glare=&#8221;0.5&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_tilt_image][et_pb_text _builder_version=&#8221;4.27.4&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;15px&#8221; header_letter_spacing=&#8221;1px&#8221; header_line_height=&#8221;1.4em&#8221; header_2_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;15px&#8221; header_2_letter_spacing=&#8221;1px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;15px&#8221; header_3_letter_spacing=&#8221;1px&#8221; header_3_line_height=&#8221;1.4em&#8221; header_4_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_4_text_color=&#8221;#000000&#8243; header_4_font_size=&#8221;17px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.4em&#8221; header_5_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_5_text_color=&#8221;#000000&#8243; header_5_font_size=&#8221;15px&#8221; header_5_letter_spacing=&#8221;1px&#8221; header_5_line_height=&#8221;1.4em&#8221; header_6_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_6_text_color=&#8221;#000000&#8243; header_6_font_size=&#8221;15px&#8221; header_6_letter_spacing=&#8221;1px&#8221; header_6_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;800px&#8221; module_alignment=&#8221;center&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<p>Sch\u00e4tzungen zufolge leiden 6,51 TP3T Menschen in Europa (9,11 TP3T Frauen und 7,41 TP3T M\u00e4nner) an Stuhlinkontinenz \u2013 das sind <strong>48 Millionen Menschen<\/strong><\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_tilt_image src=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science3shadow-2.png&#8221; title_text=&#8221;science3shadow&#8221; dsm_tilt_mobile=&#8221;on&#8221; dsm_tilt_scale=&#8221;1.1&#8243; dsm_tilt_max=&#8221;15&#8243; dsm_use_glare=&#8221;on&#8221; dsm_tilt_glare=&#8221;0.5&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_tilt_image][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.6em&#8221; header_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_text_color=&#8221;#000000&#8243; header_font_size=&#8221;15px&#8221; header_letter_spacing=&#8221;1px&#8221; header_line_height=&#8221;1.4em&#8221; header_2_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;15px&#8221; header_2_letter_spacing=&#8221;1px&#8221; header_2_line_height=&#8221;1.4em&#8221; header_3_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;15px&#8221; header_3_letter_spacing=&#8221;1px&#8221; header_3_line_height=&#8221;1.4em&#8221; header_4_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_4_text_color=&#8221;#000000&#8243; header_4_font_size=&#8221;17px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.4em&#8221; header_5_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_5_text_color=&#8221;#000000&#8243; header_5_font_size=&#8221;15px&#8221; header_5_letter_spacing=&#8221;1px&#8221; header_5_line_height=&#8221;1.4em&#8221; header_6_font=&#8221;Gotham kinda bold|||on|||||&#8221; header_6_text_color=&#8221;#000000&#8243; header_6_font_size=&#8221;15px&#8221; header_6_letter_spacing=&#8221;1px&#8221; header_6_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; max_width=&#8221;800px&#8221; module_alignment=&#8221;center&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>Stuhlinkontinenz kann folgende Ursachen haben: <strong>geburtsbedingte Verletzungen des Analsphinkters, Alterung, Darmkrebs, neurologische Erkrankungen, chronischer Durchfall und andere Darmerkrankungen oder fr\u00fchere Operationen<\/strong><\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(0,0,0,0.03)&#8221; background_position=&#8221;top_center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;100px||100px|&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;4&#8243; _builder_version=&#8221;4.16&#8243; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;0px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; parallax__hover=&#8221;off&#8221; parallax_method__hover=&#8221;on&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;How many people in Europe are affected?&#8221; url=&#8221;#&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;64px&#8221; content_max_width=&#8221;1400px&#8221; admin_label=&#8221;Chapter&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_line_height=&#8221;1.5em&#8221; body_font=&#8221;Gotham kinda bold||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.9em&#8221; background_color=&#8221;#ffffff&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;30px|40px|30px|40px&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_zoom=&#8221;20%&#8221; animation_starting_opacity=&#8221;100%&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;60px&#8221; box_shadow_color=&#8221;rgba(10,3,3,0.06)&#8221; image_max_width=&#8221;64px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">\n<p>Stuhlinkontinenz (FI) ist eine h\u00e4ufige, aber selten gemeldete Erkrankung, die die Lebensqualit\u00e4t, die soziale Teilhabe und die Inanspruchnahme von Gesundheitsleistungen erheblich beeintr\u00e4chtigt.<\/p>\n<p>Die aussagekr\u00e4ftigsten aktuellen Erkenntnisse stammen aus einer systematischen \u00dcbersicht und Metaanalyse aus dem Jahr 2024, in die 80 Studien mit mehr als 548.000 Erwachsenen weltweit einbezogen wurden <a href=\"https:\/\/www.cghjournal.org\/article\/S1542-3565(23)00715-2\/fulltext\">(Mack et al., 2024)<\/a>:<\/p>\n<ul>\n<li>Gesamtpr\u00e4valenz von FI bei Erwachsenen, die in der Gemeinschaft leben: <strong>8.0%<\/strong><\/li>\n<li>Frauen: <strong>9.1%<\/strong><\/li>\n<li>M\u00e4nner: <strong>7.4%<\/strong><\/li>\n<li>Sensitivit\u00e4tsanalysen ergaben, dass die Pr\u00e4valenz von FI in Europa bei 6,51 TP3T liegt.<\/li>\n<li>Wendet man diese Pr\u00e4valenzsch\u00e4tzungen auf die Bev\u00f6lkerung Europas (~743 Millionen Menschen) an, so l\u00e4sst sich daraus ableiten, dass etwa 48 Millionen Menschen in Europa mit FI leben.<\/li>\n<\/ul>\n<\/div>[\/et_pb_blurb][et_pb_blurb title=&#8221;What causes faecal incontinence?&#8221; url=&#8221;#&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;64px&#8221; content_max_width=&#8221;1400px&#8221; admin_label=&#8221;Chapter&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_line_height=&#8221;1.5em&#8221; body_font=&#8221;Gotham kinda bold||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.9em&#8221; background_color=&#8221;#ffffff&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;30px|40px|30px|40px&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_zoom=&#8221;20%&#8221; animation_starting_opacity=&#8221;100%&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;60px&#8221; box_shadow_color=&#8221;rgba(10,3,3,0.06)&#8221; image_max_width=&#8221;64px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>Derzeit gibt es keinen zuverl\u00e4ssigen europaweiten Datensatz, der jeden Fall von FI einer bestimmten Ursache zuordnet. In der Fachliteratur werden jedoch durchweg die folgenden wichtigen \u00e4tiologischen Gruppen genannt.<\/p>\n<ol>\n<li><strong> Geburtsbedingte Verletzung des Analsphinkters (OASI)<\/strong><\/li>\n<\/ol>\n<p>Geburtsverletzungen gelten allgemein als die <strong>h\u00e4ufigste feststellbare Ursache f\u00fcr Stuhlinkontinenz bei Frauen<\/strong>.<\/p>\n<p>Wichtigste Ergebnisse:<\/p>\n<ul>\n<li>OASI tritt bei 2,91 TP3T aller vaginalen Entbindungen im Vereinigten K\u00f6nigreich und bei 61 TP3T der Erstgeb\u00e4renden auf. <a href=\"https:\/\/www.researchgate.net\/publication\/365355927_The_incidence_of_anal_incontinence_following_obstetric_anal_sphincter_injury_OASI_graded_using_the_Sultan_classification_A_network_meta-analysis\">(Okeahialam et al., 2022)<\/a><\/li>\n<li>Mehr als <strong>Bei 20% der Frauen kann es innerhalb von f\u00fcnf Jahren nach einer vaginalen Entbindung zu einer analen Inkontinenz kommen<\/strong>, wobei die Symptome unterschiedlich stark ausgepr\u00e4gt sind. <a href=\"https:\/\/www.researchgate.net\/publication\/365355927_The_incidence_of_anal_incontinence_following_obstetric_anal_sphincter_injury_OASI_graded_using_the_Sultan_classification_A_network_meta-analysis\">(Okeahialam et al., 2022)<\/a><\/li>\n<\/ul>\n<ol start=\"2\">\n<li><strong> Altern und Degeneration des Beckenbodens<\/strong><\/li>\n<\/ol>\n<p>Das Alter ist einer der st\u00e4rksten Risikofaktoren f\u00fcr FI. Die Metaanalyse aus dem Jahr 2024 <a href=\"https:\/\/www.cghjournal.org\/article\/S1542-3565(23)00715-2\/fulltext\">(Mack et al., 2024)<\/a> gefunden:<\/p>\n<ul>\n<li>Erwachsene im Alter von \u2265 60 Jahren: <strong>9.3%-Pr\u00e4valenz<\/strong><\/li>\n<li>Erwachsene unter 60 Jahren: <strong>4,91 TP3T-Pr\u00e4valenz<\/strong><\/li>\n<\/ul>\n<p>Zu den altersbedingten Ursachen z\u00e4hlen:<\/p>\n<ul>\n<li>Fortschreitende Schlie\u00dfmuskelschw\u00e4che<\/li>\n<li>Verminderte Empfindlichkeit im Rektalbereich<\/li>\n<li>Beckenbodenfunktionsst\u00f6rung<\/li>\n<li>Gebrechlichkeit und eingeschr\u00e4nkte Mobilit\u00e4t<\/li>\n<\/ul>\n<p>Viele Experten betrachten altersbedingte Funktionsst\u00f6rungen als die <strong>gr\u00f6\u00dfter Einflussfaktor f\u00fcr die Gesamtpr\u00e4valenz von FI<\/strong>.<\/p>\n<ol start=\"3\">\n<li><strong> Darmkrebs und Krebsbehandlung<\/strong><\/li>\n<\/ol>\n<p>Fortschritte bei der Behandlung von Rektumkarzinomen haben zwar die \u00dcberlebensrate erh\u00f6ht, aber auch dazu gef\u00fchrt, dass immer mehr Patienten mit Darmfunktionsst\u00f6rungen leben m\u00fcssen.<\/p>\n<p>Bei Patienten, die sich einer sphinktererhaltenden Operation bei Rektumkarzinom unterziehen:<\/p>\n<ul>\n<li>Bei etwa 40% treten Symptome des Low-Anterior-Resection-Syndroms (LARS) auf. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7034376\/\">(Keane et al., 2020)<\/a><\/li>\n<li>Zu den Symptomen z\u00e4hlen h\u00e4ufig Harndrang, H\u00e4ufung der Blasenentleerungen, h\u00e4ufiges Wasserlassen und Stuhlinkontinenz.<\/li>\n<\/ul>\n<p>Dies ist eine der gr\u00f6\u00dften Patientengruppen, die in spezialisierten Einrichtungen f\u00fcr Kolorektal- und Beckenbodenmedizin behandelt werden.<\/p>\n<ol start=\"4\">\n<li><strong> Neurologische Erkrankung<\/strong><\/li>\n<\/ol>\n<p>Neurologische Erkrankungen k\u00f6nnen die anorektale Sensibilit\u00e4t, die Kontrolle \u00fcber den Schlie\u00dfmuskel und die Darmkoordination beeintr\u00e4chtigen. (<a href=\"https:\/\/www.nature.com\/articles\/s41572-022-00381-7\">Rao, Bharucha u. a., 2022<\/a>)<\/p>\n<p>Zu den wichtigsten Ursachen z\u00e4hlen:<\/p>\n<ul>\n<li>Schlaganfall<\/li>\n<li>Multiple Sklerose<\/li>\n<li>Parkinson-Krankheit<\/li>\n<li>R\u00fcckenmarksverletzung<\/li>\n<li>Diabetische Neuropathie<\/li>\n<\/ul>\n<p>Neurologische Erkrankungen spielen insbesondere bei \u00e4lteren Menschen und in der Langzeitpflege eine wichtige Rolle.<\/p>\n<ol start=\"5\">\n<li><strong> Chronischer Durchfall und funktionelle Darmst\u00f6rungen<\/strong><\/li>\n<\/ol>\n<p>Weicher Stuhl kann selbst einen intakten Kontinenzmechanismus \u00fcberfordern. Zu den h\u00e4ufig damit einhergehenden Erkrankungen z\u00e4hlen:<\/p>\n<ul>\n<li>Reizdarmsyndrom (IBS)<\/li>\n<li>Entz\u00fcndliche Darmerkrankungen (IBD)<\/li>\n<li>Durchfall aufgrund von Gallens\u00e4uren<\/li>\n<li>Arzneimittelbedingter Durchfall<\/li>\n<\/ul>\n<p>Diese Erkrankungen treten h\u00e4ufig entweder als Hauptursache oder als wesentlicher Mitfaktor auf.<\/p>\n<ol start=\"6\">\n<li><strong> Fr\u00fchere anorektale Operationen und Traumata<\/strong><\/li>\n<\/ol>\n<p>Ein kleinerer, aber klinisch bedeutsamer Anteil der Patienten entwickelt eine FI nach:<\/p>\n<ul>\n<li>H\u00e4morrhoidenoperation<\/li>\n<li>Operation einer Analfistel<\/li>\n<li>Verfahren zur Analdehnung<\/li>\n<li>Beckenverletzung<\/li>\n<li>Sonstige anorektale Eingriffe<\/li>\n<\/ul>[\/et_pb_blurb][et_pb_blurb title=&#8221;References&#8221; url=&#8221;#&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;64px&#8221; content_max_width=&#8221;1400px&#8221; admin_label=&#8221;Chapter&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_line_height=&#8221;1.5em&#8221; body_font=&#8221;Gotham kinda bold||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.9em&#8221; background_color=&#8221;#ffffff&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;30px|40px|30px|40px&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_zoom=&#8221;20%&#8221; animation_starting_opacity=&#8221;100%&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;0px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_blur=&#8221;60px&#8221; box_shadow_color=&#8221;rgba(10,3,3,0.06)&#8221; image_max_width=&#8221;64px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<p>Mack et al. (2024). <em>Weltweite Pr\u00e4valenz von Stuhlinkontinenz bei Erwachsenen, die zu Hause leben: Eine systematische \u00dcbersichtsarbeit und Metaanalyse<\/em>. Neurogastroenterologie und Motilit\u00e4t.<br \/><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10948379\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10948379\/<\/a><strong>\u00a0<\/strong><\/p>\n<p>Dudding TC, Vaizey CJ, Kamm MA. (2008). <em>Geburtsbedingte Verletzung des Analsphinkters: Inzidenz, Risikofaktoren und Behandlung<\/em>.<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18216527\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/18216527\/<\/a><\/p>\n<p>Okeahialam NA et al. (2022). <em>H\u00e4ufigkeit von Analinkontinenz nach einer geburtshilflichen Verletzung des Analsphinkters<\/em>.<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36379266\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36379266\/<\/a><\/p>\n<p>Rao SSC, Bharucha AE et al. (2022). <em>Stuhlinkontinenz<\/em>. Nature Reviews Disease Primers.<br \/><a href=\"https:\/\/www.nature.com\/articles\/s41572-022-00381-7\">https:\/\/www.nature.com\/articles\/s41572-022-00381-7<\/a><\/p>\n<p>Keane C et al. (2020). <em>Internationale Konsensdefinition des Syndroms der niedrigen anterioren Resektion<\/em>.<br \/><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32027242\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32027242\/<\/a><\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_section]","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module dsm_block_reveal_text dsm_block_reveal_text_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm_block_reveal_text_wrapper\" data-dsm-block-reveal-animation=\"lr\" data-dsm-block-reveal-color=\"#0e94f9\" data-dsm-block-reveal-delay=\"0\" data-dsm-block-reveal-viewport=\"80%\"><h1 class=\"dsm_block_reveal_text_header et_pb_module_header\">PR\u00c4VALENZ<\/h1><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_pb_module dsm_block_reveal_text dsm_block_reveal_text_1\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm_block_reveal_text_wrapper\" data-dsm-block-reveal-animation=\"lr\" data-dsm-block-reveal-color=\"#0e94f9\" data-dsm-block-reveal-delay=\"0.1\" data-dsm-block-reveal-viewport=\"80%\"><h2 class=\"dsm_block_reveal_text_header et_pb_module_header\">UND HAUPTURSACHEN<\/h2><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_pb_module dsm_tilt_image dsm_tilt_image_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm-tilt-image-wrapper\" data-tilt data-tilt-max=\"15\" data-tilt-speed=\"300\" data-tilt-perspective=\"1000\" data-tilt-scale=\"1.1\" data-tilt-mobile-disable=\"on\" data-tilt-glare data-tilt-max-glare=\"0.5\" data-tilt-reverse=\"false\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap\"><img decoding=\"async\" src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science1shadow-4.png\" alt=\"\" title=\"science1shadow\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Faecal incontinence is common but underreported, and can significantly impact quality of life, social functioning, and healthcare utilisation<div class=\"et_pb_module dsm_tilt_image dsm_tilt_image_1\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm-tilt-image-wrapper\" data-tilt data-tilt-max=\"15\" data-tilt-speed=\"300\" data-tilt-perspective=\"1000\" data-tilt-scale=\"1.1\" data-tilt-mobile-disable=\"on\" data-tilt-glare data-tilt-max-glare=\"0.5\" data-tilt-reverse=\"false\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap\"><img decoding=\"async\" src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science2shadow.png\" alt=\"\" title=\"science2shadow\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>It is thought that 6.5% of Europe (9.1% of women and 7.4% of men) live with faecal incontinence &#8211; that&#8217;s 48 million people<div class=\"et_pb_module dsm_tilt_image dsm_tilt_image_2\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm-tilt-image-wrapper\" data-tilt data-tilt-max=\"15\" data-tilt-speed=\"300\" data-tilt-perspective=\"1000\" data-tilt-scale=\"1.1\" data-tilt-mobile-disable=\"on\" data-tilt-glare data-tilt-max-glare=\"0.5\" data-tilt-reverse=\"false\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap\"><img decoding=\"async\" src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science3shadow-2.png\" alt=\"\" title=\"science3shadow\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Faecal incontinence may be caused by obstetric anal sphincter injury, ageing, colorectal cancer, neurological disease, chronic diarrhoea and other bowel disorders, or previous surgeries Faecal incontinence (FI) is a common but underreported condition that significantly impacts quality of life, social functioning, and healthcare utilisation. The strongest recent evidence comes from a 2024 systematic review and meta-analysis of 80 studies involving more than 548,000 adults worldwide (Mack et al, 2024): Overall prevalence of FI in community-dwelling adults: 8.0% Women: 9.1% Men: 7.4% Sensitivity analyses revealed that the prevalence of FI in Europe is 6.5% [&hellip;]<\/p>","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" custom_padding_last_edited=\"on|phone\" disabled_on=\"off|off|off\" admin_label=\"Hero section\" _builder_version=\"4.16\" background_image=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/AMELIEHEADERBACKGOUND-01-scaled.jpg\" background_position=\"center_left\" custom_margin=\"|||\" custom_padding=\"7%||7%||true|false\" custom_padding_tablet=\"15%||15%||true|false\" custom_padding_phone=\"\" global_colors_info=\"{}\"][et_pb_row use_custom_gutter=\"on\" gutter_width=\"1\" custom_padding_last_edited=\"on|desktop\" _builder_version=\"4.16\" _module_preset=\"default\" width=\"100%\" module_alignment=\"left\" custom_padding=\"|||4%|false|false\" custom_padding_tablet=\"|||6%|false|false\" custom_padding_phone=\"|||7%|false|false\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_block_reveal_text block_reveal_text=\"BENEFITS\" heading_html_tag=\"h1\" block_reveal_color=\"#0e94f9\" block_reveal_delay=\"0\" _builder_version=\"4.16\" _module_preset=\"default\" header_font=\"AMELIE||||||||\" header_text_color=\"#0e94f9\" header_font_size=\"4vw\" custom_padding=\"||||false|false\" custom_padding_tablet=\"||||false|false\" custom_padding_phone=\"||||false|false\" custom_padding_last_edited=\"on|phone\" header_font_size_tablet=\"8vw\" header_font_size_phone=\"10vw\" header_font_size_last_edited=\"on|desktop\" global_colors_info=\"{}\"][\/dsm_block_reveal_text][dsm_block_reveal_text block_reveal_text=\"OF AMELIE\" block_reveal_color=\"#0e94f9\" _builder_version=\"4.16\" _module_preset=\"default\" header_font=\"AMELIE||||||||\" header_text_color=\"#0e94f9\" header_font_size=\"3vw\" custom_padding=\"||||false|false\" custom_padding_tablet=\"||||false|false\" custom_padding_phone=\"||||false|false\" custom_padding_last_edited=\"on|phone\" header_font_size_tablet=\"6vw\" header_font_size_phone=\"7vw\" header_font_size_last_edited=\"on|desktop\" global_colors_info=\"{}\"][\/dsm_block_reveal_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" custom_padding_last_edited=\"on|phone\" _builder_version=\"4.16\" transform_scale_tablet=\"90%|90%\" transform_scale_last_edited=\"off|desktop\" transform_translate_last_edited=\"off|desktop\" transform_rotate_last_edited=\"off|desktop\" transform_skew_last_edited=\"off|desktop\" transform_origin_last_edited=\"off|desktop\" transform_styles_last_edited=\"off|desktop\" custom_margin=\"||||false|false\" custom_padding=\"100px|0px|100px|0px\" custom_padding_tablet=\"35px|0px|35px|0px|true|false\" custom_padding_phone=\"15px||15px||true|false\" global_colors_info=\"{}\"][et_pb_row column_structure=\"1_3,1_3,1_3\" _builder_version=\"4.16\" _module_preset=\"default\" animation_style=\"slide\" animation_direction=\"bottom\" animation_intensity_slide=\"11%\" global_colors_info=\"{}\"][et_pb_column type=\"1_3\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_tilt_image src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science1shadow-4.png\" title_text=\"science1shadow\" dsm_tilt_mobile=\"on\" dsm_tilt_scale=\"1.1\" dsm_tilt_max=\"15\" dsm_use_glare=\"on\" dsm_tilt_glare=\"0.5\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/dsm_tilt_image][et_pb_text _builder_version=\"4.16\" text_font=\"Gotham kinda bold||||||||\" text_text_color=\"#000000\" text_font_size=\"16px\" text_line_height=\"1.6em\" header_font=\"Gotham kinda bold|||on|||||\" header_text_color=\"#000000\" header_font_size=\"15px\" header_letter_spacing=\"1px\" header_line_height=\"1.4em\" header_2_font=\"Gotham kinda bold|||on|||||\" header_2_text_color=\"#000000\" header_2_font_size=\"15px\" header_2_letter_spacing=\"1px\" header_2_line_height=\"1.4em\" header_3_font=\"Gotham kinda bold|||on|||||\" header_3_text_color=\"#000000\" header_3_font_size=\"15px\" header_3_letter_spacing=\"1px\" header_3_line_height=\"1.4em\" header_4_font=\"Gotham kinda bold|||on|||||\" header_4_text_color=\"#000000\" header_4_font_size=\"17px\" header_4_letter_spacing=\"1px\" header_4_line_height=\"1.4em\" header_5_font=\"Gotham kinda bold|||on|||||\" header_5_text_color=\"#000000\" header_5_font_size=\"15px\" header_5_letter_spacing=\"1px\" header_5_line_height=\"1.4em\" header_6_font=\"Gotham kinda bold|||on|||||\" header_6_text_color=\"#000000\" header_6_font_size=\"15px\" header_6_letter_spacing=\"1px\" header_6_line_height=\"1.4em\" text_orientation=\"center\" max_width=\"800px\" module_alignment=\"center\" locked=\"off\" global_colors_info=\"{}\"]<p>Potential new regenerative therapies to address unmet clinical needs of large patient groups identified.<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_tilt_image src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science2shadow.png\" title_text=\"science2shadow\" dsm_tilt_mobile=\"on\" dsm_tilt_scale=\"1.1\" dsm_tilt_max=\"15\" dsm_use_glare=\"on\" dsm_tilt_glare=\"0.5\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/dsm_tilt_image][et_pb_text _builder_version=\"4.16\" text_font=\"Gotham kinda bold||||||||\" text_text_color=\"#000000\" text_font_size=\"16px\" text_line_height=\"1.6em\" header_font=\"Gotham kinda bold|||on|||||\" header_text_color=\"#000000\" header_font_size=\"15px\" header_letter_spacing=\"1px\" header_line_height=\"1.4em\" header_2_font=\"Gotham kinda bold|||on|||||\" header_2_text_color=\"#000000\" header_2_font_size=\"15px\" header_2_letter_spacing=\"1px\" header_2_line_height=\"1.4em\" header_3_font=\"Gotham kinda bold|||on|||||\" header_3_text_color=\"#000000\" header_3_font_size=\"15px\" header_3_letter_spacing=\"1px\" header_3_line_height=\"1.4em\" header_4_font=\"Gotham kinda bold|||on|||||\" header_4_text_color=\"#000000\" header_4_font_size=\"17px\" header_4_letter_spacing=\"1px\" header_4_line_height=\"1.4em\" header_5_font=\"Gotham kinda bold|||on|||||\" header_5_text_color=\"#000000\" header_5_font_size=\"15px\" header_5_letter_spacing=\"1px\" header_5_line_height=\"1.4em\" header_6_font=\"Gotham kinda bold|||on|||||\" header_6_text_color=\"#000000\" header_6_font_size=\"15px\" header_6_letter_spacing=\"1px\" header_6_line_height=\"1.4em\" text_orientation=\"center\" max_width=\"800px\" module_alignment=\"center\" locked=\"off\" global_colors_info=\"{}\"]<p>Europe\u2019s position in translational regenerative medicine strengthened.<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][dsm_tilt_image src=\"https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/09\/science3shadow-2.png\" title_text=\"science3shadow\" dsm_tilt_mobile=\"on\" dsm_tilt_scale=\"1.1\" dsm_tilt_max=\"15\" dsm_use_glare=\"on\" dsm_tilt_glare=\"0.5\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/dsm_tilt_image][et_pb_text _builder_version=\"4.16\" text_font=\"Gotham kinda bold||||||||\" text_text_color=\"#000000\" text_font_size=\"16px\" text_line_height=\"1.6em\" header_font=\"Gotham kinda bold|||on|||||\" header_text_color=\"#000000\" header_font_size=\"15px\" header_letter_spacing=\"1px\" header_line_height=\"1.4em\" header_2_font=\"Gotham kinda bold|||on|||||\" header_2_text_color=\"#000000\" header_2_font_size=\"15px\" header_2_letter_spacing=\"1px\" header_2_line_height=\"1.4em\" header_3_font=\"Gotham kinda bold|||on|||||\" header_3_text_color=\"#000000\" header_3_font_size=\"15px\" header_3_letter_spacing=\"1px\" header_3_line_height=\"1.4em\" header_4_font=\"Gotham kinda bold|||on|||||\" header_4_text_color=\"#000000\" header_4_font_size=\"17px\" header_4_letter_spacing=\"1px\" header_4_line_height=\"1.4em\" header_5_font=\"Gotham kinda bold|||on|||||\" header_5_text_color=\"#000000\" header_5_font_size=\"15px\" header_5_letter_spacing=\"1px\" header_5_line_height=\"1.4em\" header_6_font=\"Gotham kinda bold|||on|||||\" header_6_text_color=\"#000000\" header_6_font_size=\"15px\" header_6_letter_spacing=\"1px\" header_6_line_height=\"1.4em\" text_orientation=\"center\" max_width=\"800px\" module_alignment=\"center\" locked=\"off\" global_colors_info=\"{}\"]<p>New therapies for major human diseases and conditions, and new approaches for therapy taken further in the development pipeline.<\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.16\" background_color=\"rgba(0,0,0,0.03)\" background_position=\"top_center\" custom_margin=\"|||\" custom_padding=\"100px||100px|\" global_colors_info=\"{}\"][et_pb_row use_custom_gutter=\"on\" gutter_width=\"4\" _builder_version=\"4.16\" custom_margin=\"||||false|false\" custom_padding=\"0px|||\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" parallax__hover=\"off\" parallax_method__hover=\"on\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Potential new regenerative therapies to address unmet clinical needs of large patient groups identified\" url=\"#\" icon_placement=\"left\" image_icon_width=\"64px\" content_max_width=\"1400px\" admin_label=\"Chapter\" _builder_version=\"4.16\" header_font=\"Gotham kinda bold||||||||\" header_text_color=\"#000000\" header_line_height=\"1.5em\" body_font=\"Gotham kinda bold||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.9em\" background_color=\"#ffffff\" custom_margin=\"|||\" custom_padding=\"30px|40px|30px|40px\" animation_style=\"zoom\" animation_direction=\"bottom\" animation_intensity_zoom=\"20%\" animation_starting_opacity=\"100%\" box_shadow_style=\"preset2\" box_shadow_horizontal=\"0px\" box_shadow_vertical=\"0px\" box_shadow_blur=\"60px\" box_shadow_color=\"rgba(10,3,3,0.06)\" image_max_width=\"64px\" locked=\"off\" global_colors_info=\"{}\"]<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">Faecal incontinence is a common condition affecting approximately 9% of adults in Europe. However, this figure is likely underestimated, as around 70% of individuals do not seek medical advice. Of those who do consult a healthcare professional, only a proportion pursue further treatment, and approximately half are not suitable for currently available options.<\/div>\n<div class=\"x_elementToProof\">The AMELIE approach offers several advantages over existing surgical interventions, which can carry risks such as infection, pain, and device failure or dislocation, sometimes resulting in the need for a permanent stoma. Improved continence outcomes have the potential to benefit not only patients, but also carers and individuals on nursing home waiting lists.<\/div>\n<div class=\"x_elementToProof\">If effective, treatment using implantable cell\u2013microcarrier technology could significantly improve quality of life for citizens across Europe. Presenting this therapy as a realistic option for restoring continence, rather than solely managing symptoms, may also encourage more patients to seek medical advice, thereby increasing access to treatment.<\/div>[\/et_pb_blurb][et_pb_blurb title=\"Europe\u2019s position in translational regenerative medicine strengthened \" url=\"#\" icon_placement=\"left\" image_icon_width=\"64px\" content_max_width=\"1400px\" admin_label=\"Chapter\" _builder_version=\"4.16\" header_font=\"Gotham kinda bold||||||||\" header_text_color=\"#000000\" header_line_height=\"1.5em\" body_font=\"Gotham kinda bold||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.9em\" background_color=\"#ffffff\" custom_margin=\"|||\" custom_padding=\"30px|40px|30px|40px\" animation_style=\"zoom\" animation_direction=\"bottom\" animation_intensity_zoom=\"20%\" animation_starting_opacity=\"100%\" box_shadow_style=\"preset2\" box_shadow_horizontal=\"0px\" box_shadow_vertical=\"0px\" box_shadow_blur=\"60px\" box_shadow_color=\"rgba(10,3,3,0.06)\" image_max_width=\"64px\" locked=\"off\" global_colors_info=\"{}\"]<p><span style=\"font-weight: 400;\">Europe is world-leading in cell-based therapies for patients with FI.<\/span> <span style=\"font-weight: 400;\">As well as reinforcing Europe\u2019s dominant role in the field, AMELIE also represents a step-change in the approach being taken to manufacture and deliver cell-based medicine that will enable European citizens to be the first worldwide to benefit from a pioneering new approach to regenerative medicine.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cell therapy is a rapidly growing area of research. Tissue engineered products are set to grow significantly and provide substantial opportunities to strengthen Europe\u2019s position in translational regenerative medicine. Europe is responsible for approximately 26% of global regenerative medicine companies. The development of innovative technology such as implantable TIPS microcarriers will draw investment to Europe. AMELIE then seeks to advance the competitive positions of European companies as providers of innovative enabling technologies for regenerative medicine. This will enhance AMELIE\u2019s exploitative potential.<\/span><\/p>[\/et_pb_blurb][et_pb_blurb title=\"New therapies for major human diseases and conditions, and new approaches for therapy taken further in the development pipeline\" url=\"#\" icon_placement=\"left\" image_icon_width=\"64px\" content_max_width=\"1400px\" admin_label=\"Chapter\" _builder_version=\"4.16\" header_font=\"Gotham kinda bold||||||||\" header_text_color=\"#000000\" header_line_height=\"1.5em\" body_font=\"Gotham kinda bold||||||||\" body_text_color=\"#000000\" body_font_size=\"16px\" body_line_height=\"1.9em\" background_color=\"#ffffff\" custom_margin=\"|||\" custom_padding=\"30px|40px|30px|40px\" animation_style=\"zoom\" animation_direction=\"bottom\" animation_intensity_zoom=\"20%\" animation_starting_opacity=\"100%\" box_shadow_style=\"preset2\" box_shadow_horizontal=\"0px\" box_shadow_vertical=\"0px\" box_shadow_blur=\"60px\" box_shadow_color=\"rgba(10,3,3,0.06)\" image_max_width=\"64px\" locked=\"off\" global_colors_info=\"{}\"]<p><span style=\"font-weight: 400;\">AMELIE paves the way for identical or similar innovative treatments using ASMDC cell-microcarrier combinations for a variety of other clinical conditions associated with loss of skeletal muscle function, such as urinary incontinence, muscular dystrophies and volumetric muscle loss associated with trauma injury.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The same scientific rationale and new approach developed in AMELIE is equally applicable to other anchorage-dependent cell types investigated as new regenerative medicine treatments. New products comprised of these anchorage-dependent cells are intended to treat some of the most debilitating diseases that affect muscle, bone, cartilage, ocular, heart\/cardiovascular, gastrointestinal\/liver, kidney, immune and respiratory tissues. Adoption of the implantable TIPS microcarrier technology could have a significant impact on their outcome.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Meanwhile the scale-up manufacturing process for TIPS microparticles developed can be applied to other uses of the microparticle technology currently being investigated in the development pipeline. <\/span><\/p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.16\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_section]","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-31818","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/pages\/31818","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/comments?post=31818"}],"version-history":[{"count":8,"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/pages\/31818\/revisions"}],"predecessor-version":[{"id":31830,"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/pages\/31818\/revisions\/31830"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/de\/wp-json\/wp\/v2\/media?parent=31818"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}