{"id":31500,"date":"2025-04-16T09:25:41","date_gmt":"2025-04-16T09:25:41","guid":{"rendered":"https:\/\/amelie-project.eu\/?post_type=publication&p=31500"},"modified":"2025-04-16T09:25:45","modified_gmt":"2025-04-16T09:25:45","slug":"regenerativ-behandling-kan-vaere-en-kur-for-inkontinenspatienter","status":"publish","type":"publication","link":"https:\/\/amelie-project.eu\/da\/udgivelse\/regenerativ-behandling-kan-vaere-en-kur-for-inkontinenspatienter\/","title":{"rendered":"Regenerativ behandling kan v\u00e6re en kur for inkontinenspatienter"},"content":{"rendered":"[et_pb_section fb_built=”1″ admin_label=”section” _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row admin_label=”row” _builder_version=”4.21.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Text” _builder_version=”4.21.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”]\n

Day RM, Knowles CK<\/span>.<\/strong><\/p>\n

Avisen The Guardian 20. juni 2024, side 7.<\/p>\n

Introduktion<\/em><\/p>\n

Patienter, hvis liv er blevet forringet af aff\u00f8ringsinkontinens, f\u00e5r nyt h\u00e5b med en foresl\u00e5et teknologi, der kan tilbyde en potentiel kur, snarere end behandling, af deres tilstand.<\/p>\n

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F\u00e5 adgang til hele artiklen her:<\/p>\n

https:\/\/issuu.com\/mediaplanetuk\/docs\/bladder_bowel_health<\/a><\/p>\n

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Day RM, Knowles CK. The Guardian newspaper 20th June 2024, page 7. Introduction Patients whose lives have been impaired by faecal incontinence are offered new hope with proposed technology that could offer a potential cure, rather than management, of their condition.   Access the full article here: https:\/\/issuu.com\/mediaplanetuk\/docs\/bladder_bowel_health                      <\/p>","protected":false},"featured_media":31502,"template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\n

Charlotte Desprez, Davide Danovi, Charles H Knowles and Richard M Day.<\/p>\n\n\n\n

J. Tissue Eng. 2023;14:1\u201318.<\/p>\n\n\n\n

Abstract<\/em><\/p>\n\n\n\n

Skeletal muscle-derived cells (SMDC) hold tremendous potential for replenishing dysfunctional muscle lost due to disease or trauma. Current therapeutic usage of SMDC relies on harvesting autologous cells from muscle biopsies that are subsequently expanded in vitro before re-implantation into the patient. Heterogeneity can arise from multiple factors including quality of the starting biopsy, age and comorbidity affecting the processed SMDC. Quality attributes intended for clinical use often focus on minimum levels of myogenic cell marker expression. Such approaches do not evaluate the likelihood of SMDC to differentiate and form myofibres when implanted in vivo, which ultimately determines the likelihood of muscle regeneration. Predicting the therapeutic potency of SMDC in vitro prior to implantation is key to developing successful therapeutics in regenerative medicine and reducing implementation costs. Here, we report on the development of a novel SMDC profiling tool to examine populations of cells in vitro derived from different donors. We developed an image-based pipeline to quantify morphological features and extracted cell shape descriptors. We investigated whether these could predict heterogeneity in the formation of myotubes and correlate with the myogenic fusion index. Several of the early cell shape characteristics were found to negatively correlate with the fusion index. These included total area occupied by cells, area shape, bounding box area, compactness, equivalent diameter, minimum ferret diameter, minor axis length and perimeter of SMDC at 24 h after initiating culture. The information extracted with our approach indicates live cell imaging can detect a range of cell phenotypes based on cell-shape alone and preserving cell integrity could be used to predict propensity to form myotubes in vitro and functional tissue in vivo.<\/p>\n\n\n\n

Access the full paper here: https:\/\/pubmed.ncbi.nlm.nih.gov\/36949843\/<\/a><\/p>\n","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_links_to":"","_links_to_target":""},"categories":[43],"class_list":["post-31500","publication","type-publication","status-publish","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/publication\/31500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/types\/publication"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/media\/31502"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/media?parent=31500"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/categories?post=31500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}