{"id":31811,"date":"2026-07-01T15:31:55","date_gmt":"2026-07-01T15:31:55","guid":{"rendered":"https:\/\/amelie-project.eu\/?p=31811"},"modified":"2026-07-01T15:35:57","modified_gmt":"2026-07-01T15:35:57","slug":"opdatering-om-amelie-projektet-milepaele-i-de-tidlige-kliniske-forsog-er-naet","status":"publish","type":"post","link":"https:\/\/amelie-project.eu\/da\/opdatering-om-amelie-projektet-milepaele-i-de-tidlige-kliniske-forsog-er-naet\/","title":{"rendered":"Opdatering om AMELIE-projektet: De f\u00f8rste milep\u00e6le i det kliniske fors\u00f8g er n\u00e5et"},"content":{"rendered":"[et_pb_section fb_built=\u201d1\u2033 admin_label=\u201dsection\u201d _builder_version=\u201d4.16\u2033 global_colors_info=\u201d{}\u201d theme_builder_area=\u201dpost_content\u201d][et_pb_row admin_label=\u201drow\u201d _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d custom_padding=\u201d|||0px||\u201d global_colors_info=\u201d{}\u201d theme_builder_area=\u201dpost_content\u201d][et_pb_column type=\u201d4_4\u2033 _builder_version=\u201d4.16\u2033 custom_padding=\u201d|||\u201d global_colors_info=\u201d{}\u201d custom_padding__hover=\u201d|||\u201d theme_builder_area=\u201dpost_content\u201d][et_pb_text admin_label=\u201dText\u201d _builder_version=\u201d4.16\u2033 background_size=\u201dinitial\u201d background_position=\u201dtop_left\u201d background_repeat=\u201drepeat\u201d global_colors_info=\u201d{}\u201d theme_builder_area=\u201dpost_content\u201d]
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Vi er glade for at kunne fort\u00e6lle om en vigtig milep\u00e6l i AMELIE-projektet, der har til form\u00e5l at udvikle en ny regenerativ behandling mod f\u00e6kal inkontinens.

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Indtil videre er fire patienter blevet behandlet p\u00e5 The Royal London Hospital i London, og to patienter er blevet behandlet p\u00e5 University Hospital of Wales i Cardiff som led i det igangv\u00e6rende kliniske fors\u00f8g.<\/p>\n<\/div>\n

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Dette udg\u00f8r et v\u00e6sentligt fremskridt i evalueringen af en ny cellebaseret terapi, der har til form\u00e5l at genoprette lukkemuskelens funktion ved hj\u00e6lp af autologe celler fra skeletmuskulaturen, der er fastgjort til implanterbare mikrob\u00e6rere. Metoden er udviklet med henblik p\u00e5 at forbedre cellernes overlevelse, fremme v\u00e6vsreparation og i sidste ende forbedre kontinensresultaterne for patienter, der lever med denne udfordrende tilstand.<\/p>\n<\/div>\n


Hvert patientforl\u00f8b indledes med en muskelbiopsi, hvor der udtages de celler, der er n\u00f8dvendige for at fremstille den skr\u00e6ddersyede behandling. Disse celler behandles og forberedes derefter til implantation, inden de inds\u00e6ttes i patienten p\u00e5 et af de deltagende behandlingssteder.<\/div>\n

Behandlingen af disse seks patienter udg\u00f8r en vigtig milep\u00e6l i overgangen fra laboratorieudvikling til klinisk praksis for AMELIE. Den afspejler ogs\u00e5 det t\u00e6tte samarbejde mellem kirurger, forskere, produktionshold og personale i kliniske fors\u00f8g i hele Storbritannien.<\/div>\n

I takt med at fors\u00f8get skrider frem, vil teamet fortsat n\u00f8je overv\u00e5ge resultaterne for at vurdere sikkerheden og de f\u00f8rste tegn p\u00e5 effektivitet.<\/div>\n

Vi ser frem til at dele yderligere opdateringer, efterh\u00e5nden som denne banebrydende unders\u00f8gelse skrider frem.<\/div>\n
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<\/em><\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]","protected":false},"excerpt":{"rendered":"

We are pleased to share an important milestone in the AMELIE project, which is developing a novel regenerative treatment for faecal incontinence. To date, four patients have been treated at The Royal London Hospital in London, and two patients have been treated at the University Hospital of Wales in Cardiff as part of the ongoing clinical trial. This marks a significant step forward in the evaluation of a new cell-based therapy that aims to restore sphincter function by using autologous skeletal muscle-derived cells attached to implantable microcarriers. The approach is designed to improve cell survival, support tissue repair, and ultimately improve continence outcomes for patients living with this challenging condition. Each patient pathway begins with a muscle biopsy to collect the cells needed to manufacture the personalised therapy. These cells are then processed and prepared for implantation, before being delivered back to the patient at one of the participating clinical sites. The treatment of these six patients represents a key milestone in the translation of AMELIE from laboratory development into clinical practice. It also reflects the close collaboration between surgeons, scientists, manufacturing teams, and clinical trial staff across the UK. As the trial progresses, the team will continue carefully monitor […]<\/p>","protected":false},"author":6,"featured_media":31815,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" admin_label=\"section\" _builder_version=\"4.16\" global_colors_info=\"{}\" theme_builder_area=\"post_content\"][et_pb_row admin_label=\"row\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_padding=\"|||0px||\" global_colors_info=\"{}\" theme_builder_area=\"post_content\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" global_colors_info=\"{}\" custom_padding__hover=\"|||\" theme_builder_area=\"post_content\"][et_pb_text admin_label=\"Text\" _builder_version=\"4.16\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" global_colors_info=\"{}\" theme_builder_area=\"post_content\"]

The first patient was recently treated in the AMELIE clinical trial during April 2026. The team at The Royal London Hospital implanted healthy muscle cells attached to microscopic beads in humans for the first time. The study aims to treat faecal incontinence caused by childbirth injury.<\/span><\/p>\n

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The first patients had been biopsied two weeks prior to this in Cardiff at the University Hospital of Wales.<\/p>\n

These are important milestones for the progression of this groundbreaking treatment. The team looks forward to treating the remaining patients enrolled in the trial in the coming months.<\/p>\n<\/div>\n

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