{"id":30450,"date":"2020-12-16T16:08:01","date_gmt":"2020-12-16T16:08:01","guid":{"rendered":"https:\/\/amelie-project.eu\/?page_id=30450"},"modified":"2026-07-01T10:12:20","modified_gmt":"2026-07-01T10:12:20","slug":"vores-forskning","status":"publish","type":"page","link":"https:\/\/amelie-project.eu\/da\/vores-forskning\/","title":{"rendered":"Vores forskning"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Hero section&#8221; _builder_version=&#8221;4.16&#8243; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/10\/AMELIEHEADERBACKGOUND-01-scaled.jpg&#8221; background_position=&#8221;center_left&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;7%||7%||true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; module_alignment=&#8221;left&#8221; custom_padding=&#8221;|||4%|false|false&#8221; custom_padding_tablet=&#8221;|||5%|false|false&#8221; custom_padding_phone=&#8221;|||5.5%|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][dsm_block_reveal_text block_reveal_text=&#8221;OUR RESEARCH&#8221; heading_html_tag=&#8221;h1&#8243; block_reveal_color=&#8221;#0e94f9&#8243; block_reveal_delay=&#8221;0&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;AMELIE||||||||&#8221; header_text_color=&#8221;#0e94f9&#8243; header_font_size=&#8221;3vw&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_tablet=&#8221;||||false|false&#8221; custom_padding_phone=&#8221;||||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; header_font_size_tablet=&#8221;5vw&#8221; header_font_size_phone=&#8221;6vw&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;][\/dsm_block_reveal_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; admin_label=&#8221;Collections&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;100px|0px|100px|0px|false|false&#8221; custom_padding_tablet=&#8221;50px||50px||true|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; make_equal=&#8221;on&#8221; custom_padding_last_edited=&#8221;off|tablet&#8221; module_id=&#8221;faecal-incontinence-about-the-condition&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_margin_tablet=&#8221;||||false|false&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|tablet&#8221; custom_padding=&#8221;0px||0px|&#8221; box_shadow_style=&#8221;preset3&#8243; box_shadow_vertical=&#8221;40px&#8221; box_shadow_blur=&#8221;50px&#8221; box_shadow_color=&#8221;rgba(0,0,0,0.1)&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_direction=&#8221;35deg&#8221; background_color_gradient_stops=&#8221;#6bc8ff 0%|#99afff 100%&#8221; background_color_gradient_start=&#8221;#6bc8ff&#8221; background_color_gradient_end=&#8221;#99afff&#8221; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/12\/Asset-1.png&#8221; custom_padding=&#8221;5%|5%|5%|5%|true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;40px|40px|40px|40px&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;AMELIE||||||||&#8221; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_3_font=&#8221;Gotham kinda bold||||||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;28px&#8221; header_3_line_height=&#8221;1.5em&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||10px|&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>F\u00e6kal inkontinens: Konsekvenser for patienterne<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.9em&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-weight: 400;\">F\u00e6kal inkontinens udg\u00f8r et betydeligt folkesundhedsproblem. <\/span>Tilstanden kan have alvorlige konsekvenser for hverdagen, herunder:<\/p>\n<ul>\n<li>v\u00e6rdighed og selvtillid<\/li>\n<li>trivsel og psykisk sundhed<\/li>\n<li>uafh\u00e6ngighed<\/li>\n<\/ul>\n<div class=\"x_elementToProof\">Mange mennesker oplever:<\/div>\n<ul>\n<li>angst<\/li>\n<li>social isolation<\/li>\n<li>mindre deltagelse i arbejdslivet og rejseaktiviteter<\/li>\n<li>begr\u00e6nsninger i dagligdags aktiviteter<\/li>\n<\/ul>\n<div class=\"x_elementToProof\">AMELIE-projektet fokuserer specifikt p\u00e5 f\u00e6kal inkontinens som f\u00f8lge af skader p\u00e5 analsfinkteren, oftest efter:<\/div>\n<ul>\n<li>f\u00f8dsel<\/li>\n<li>kirurgi<\/li>\n<li>traume<\/li>\n<\/ul>\n<div class=\"x_elementToProof\">Kvinder, der har f\u00f8dt, udg\u00f8r en stor andel af de ber\u00f8rte personer, idet ca. 5,5% har p\u00e5draget sig direkte skader under f\u00f8dslen som f\u00f8lge af perineale bristninger.<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|tablet&#8221; admin_label=&#8221;Collections&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;0px|0px|100px|0px|false|false&#8221; custom_padding_tablet=&#8221;||50px||false|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;3_5,2_5&#8243; make_equal=&#8221;on&#8221; module_id=&#8221;faecal-incontinence-and-regenerative-medicine&#8221; _builder_version=&#8221;4.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;0px||0px|&#8221; hover_enabled=&#8221;0&#8243; box_shadow_style=&#8221;preset3&#8243; box_shadow_vertical=&#8221;40px&#8221; box_shadow_blur=&#8221;50px&#8221; box_shadow_color=&#8221;rgba(0,0,0,0.1)&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;][et_pb_column type=&#8221;3_5&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;40px|40px|40px|40px&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; custom_css_main_element_last_edited=&#8221;off|phone&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;AMELIE||||||||&#8221; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_3_font=&#8221;Gotham kinda bold||||||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;28px&#8221; header_3_line_height=&#8221;1.5em&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||10px|&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>F\u00e6kal inkontinens og regenerativ medicin<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.9em&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">\n<p>Regenerativ medicin har til form\u00e5l at reparere eller erstatte v\u00e6v, der er blevet beskadiget af aldring, sygdom eller skade, og \u00e5bner dermed nye muligheder for behandling af f\u00e6kal inkontinens for\u00e5rsaget af skader p\u00e5 den ydre analsfinkter. Blandt de regenerative tilgange er celleterapi, hvor der anvendes autologe celler fra skeletmuskulaturen (ASMDC'er) til at regenerere den beskadigede ydre analsfinkter, den mest udforskede.<\/p>\n<\/div>\n<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\"><\/div>\n<div class=\"x_elementToProof\">Europa har spillet en f\u00f8rende rolle i at oms\u00e6tte denne tilgang til klinisk praksis. Af de fem offentliggjorte kliniske studier af celleterapi mod f\u00e6kal inkontinens blev tre gennemf\u00f8rt af europ\u00e6iske forskergrupper, og her blev der anvendt ASMDC\u2019er, der blev indgivet som en cellesuspension. I det randomiserede, placebokontrollerede fase II-fors\u00f8g reagerede kun 58% af de patienter, der modtog ASMDC-terapi, efter 12 m\u00e5neder, mens \u00e5bne pilotunders\u00f8gelser rapporterede om lignende niveauer af subjektiv forbedring. Samlet set har disse unders\u00f8gelser kun p\u00e5vist en beskeden klinisk fordel, hvilket tyder p\u00e5, at de nuv\u00e6rende metoder til celleindgivelse ikke konsekvent opn\u00e5r den \u00f8nskede terapeutiske effekt.<\/div>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_direction=&#8221;35deg&#8221; background_color_gradient_stops=&#8221;#6bc8ff 0%|#99afff 100%&#8221; background_color_gradient_start=&#8221;#6bc8ff&#8221; background_color_gradient_end=&#8221;#99afff&#8221; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/12\/Asset-3.png&#8221; custom_padding=&#8221;5%|5%|5%|5%|true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; custom_css_main_element_last_edited=&#8221;off|desktop&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|tablet&#8221; admin_label=&#8221;Collections&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;0px|0px|100px|0px|false|false&#8221; custom_padding_tablet=&#8221;||100px||false|false&#8221; custom_padding_phone=&#8221;&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; make_equal=&#8221;on&#8221; module_id=&#8221;why-are-conventional-methods-not-working&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;0px||0px|&#8221; box_shadow_style=&#8221;preset3&#8243; box_shadow_vertical=&#8221;40px&#8221; box_shadow_blur=&#8221;50px&#8221; box_shadow_color=&#8221;rgba(0,0,0,0.1)&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_direction=&#8221;35deg&#8221; background_color_gradient_stops=&#8221;#6bc8ff 0%|#99afff 100%&#8221; background_color_gradient_start=&#8221;#6bc8ff&#8221; background_color_gradient_end=&#8221;#99afff&#8221; background_image=&#8221;https:\/\/amelie-project.eu\/wp-content\/uploads\/2020\/12\/Asset-2.png&#8221; custom_padding=&#8221;5%|5%|5%|5%|true|false&#8221; custom_padding_tablet=&#8221;15%||15%||true|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; admin_label=&#8221;Column&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;40px|40px|40px|40px&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;AMELIE||||||||&#8221; header_font=&#8221;Gotham kinda bold||||||||&#8221; header_text_color=&#8221;#000000&#8243; header_3_font=&#8221;Gotham kinda bold||||||||&#8221; header_3_text_color=&#8221;#000000&#8243; header_3_font_size=&#8221;28px&#8221; header_3_line_height=&#8221;1.5em&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;||10px|&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Hvorfor giver de traditionelle metoder ikke bedre resultater?<\/h3>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Gotham kinda bold||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;16px&#8221; text_line_height=&#8221;1.9em&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div class=\"x_elementToProof\" data-olk-copy-source=\"MessageBody\">Mange af de celler, der anvendes inden for regenerativ medicin, herunder autologe celler fra skeletmuskulaturen (ASMDC\u2019er), er<span>\u00a0<\/span><b>forankringsafh\u00e6ngig<\/b>, hvilket betyder, at de skal forblive fastgjort til en overflade for at kunne vokse og fungere normalt. Ved konventionel fremstilling isoleres disse celler fra patienten, dyrkes i laboratoriet, mens de er fastgjort til en dyrkningsoverflade, og l\u00f8snes derefter, inden de indgives som en cellesuspension.<\/div>\n<div class=\"x_elementToProof\">Hidtil har alle offentliggjorte kliniske unders\u00f8gelser af celleterapi mod f\u00e6kal inkontinens anvendt denne konventionelle fremstillingsmetode. At l\u00f8srive cellerne fra deres dyrkningsunderlag f\u00f8r transplantation kan imidlertid beskadige dem og dermed reducere deres levedygtighed og regenerative potentiale. Denne proces kan ogs\u00e5 udl\u00f8se anoikis \u2013 en form for celled\u00f8d, der opst\u00e5r, n\u00e5r forankringsafh\u00e6ngige celler mister kontakten med deres underlag.<\/div>\n<div class=\"x_elementToProof\">D\u00e5rlig celleoverlevelse efter transplantation er en af de st\u00f8rste udfordringer inden for regenerativ medicin. For behandlinger, der bygger p\u00e5, at cellerne integreres i beskadiget muskelv\u00e6v \u2013 s\u00e5som behandlinger mod f\u00e6kal inkontinens \u2013 kan lav celleoverlevelse begr\u00e6nse effektiviteten og medf\u00f8re uensartede kliniske resultater.<\/div>\n<div class=\"x_elementToProof\">At tackle denne udfordring er kernen i AMELIE-projektet. Ved at udvikle en implant\u00e9rbar celle-mikrob\u00e6rer-terapi, der g\u00f8r det muligt for cellerne at forblive fastgjort til et underst\u00f8ttende skelet under transplantationen, sigter konsortiet mod at forbedre cellernes overlevelse, fremme v\u00e6vsreparation og opn\u00e5 bedre resultater for patienterne.<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"<p><div class=\"et_pb_module dsm_block_reveal_text dsm_block_reveal_text_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module_inner\">\n\t\t\t\t\t<div class=\"dsm_block_reveal_text_wrapper\" data-dsm-block-reveal-animation=\"lr\" data-dsm-block-reveal-color=\"#0e94f9\" data-dsm-block-reveal-delay=\"0\" data-dsm-block-reveal-viewport=\"80%\"><h1 class=\"dsm_block_reveal_text_header et_pb_module_header\">VORES FORSKNING<\/h1><\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>Faecal Incontinence: Impact on PatientsFaecal incontinence is a substantial public health problem. The condition can severely affect everyday life, including: dignity and confidence wellbeing and mental health independence Many individuals experience: anxiety social isolation reduced participation in work and travel limitations in daily activities The AMELIE project focuses specifically on faecal incontinence resulting from injury to the anal sphincter, most commonly following: childbirth surgery trauma Women who have given birth represent a large proportion of affected individuals, with around 5.5% experiencing direct injury during childbirth due to perineal tearing.Faecal Incontinence and Regenerative Medicine Regenerative medicine seeks to repair or replace tissue that has been damaged by ageing, disease or injury, offering new possibilities for treating faecal incontinence caused by injury to the anal sphincter. Among regenerative approaches, cell therapy using autologous skeletal muscle-derived cells (ASMDCs) to regenerate the damaged external anal sphincter has been the most extensively investigated. Europe has played a leading role in translating this approach into clinical practice. Of the five published clinical studies of cell therapy for faecal incontinence, three were conducted by European research groups and used [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-30450","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/pages\/30450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/comments?post=30450"}],"version-history":[{"count":23,"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/pages\/30450\/revisions"}],"predecessor-version":[{"id":31786,"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/pages\/30450\/revisions\/31786"}],"wp:attachment":[{"href":"https:\/\/amelie-project.eu\/da\/wp-json\/wp\/v2\/media?parent=30450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}